AstraZeneca CEO: ‘Biology will catch up with me at some point’
Long-serving pharma chief Pascal Soriot hopes research and risk-taking will secure growth in China and US
When the AstraZeneca board rejected a near £70bn bid from Pfizer that would have created one of the world’s biggest pharmaceutical companies, chief executive Sir Pascal Soriot understood the gamble they were taking.
The approach more than a decade ago offered a lifeline for struggling AstraZeneca, which Soriot had then led for less than two years, and shareholders were excited.
Yet Soriot was always confident walking away was the right move. As he rang the opening bell at the New York Stock Exchange last month to celebrate the company’s recent direct listing on the bourse, he said the decision “quite frankly . . . has worked better than we could have imagined”.
Pfizer’s final offer in 2014 was £55 a share. AstraZeneca now trades at about £128 a share and its £207bn market cap makes it more valuable than its would-be buyer. “We thought we had what it took to create more value on our own,” Soriot tells the FT.
Such calculated risk-taking has characterised the 67-year-old’s time at the company he joined in October 2012. To meet ambitious growth targets, he has focused on in-house drug development, US expansion and investing in emerging markets before it became fashionable in the sector, making AstraZeneca the largest western pharma company in China.
A French-Australian national who studied veterinary medicine in Paris before moving to New Zealand and Australia in his twenties, Soriot has credited his appetite for a fight in part to a childhood in Paris’s banlieues, the gritty suburbs outside the city.
AstraZeneca hired him as chief executive from Swiss rival Roche in a period of turmoil. His predecessor resigned under pressure from shareholders unhappy with setbacks in late-stage trials aimed at replacing blockbuster drugs losing patent exclusivity.
Soriot’s response was, and continues to be, investment in research and development, particularly in two countries — China and the US — at the vanguard of pharmaceutical innovation. He has committed billions of dollars in China — in January announcing $15bn of investment by 2030 — to build manufacturing capacity, strike deals with local biotech firms and establish a new R&D site in Beijing. That research pipeline is expected to funnel medicines for sale globally and especially in the US, a growth market that brought in 43 per cent of group revenue last year.
The approach requires walking a geopolitical tightrope that has recently become more treacherous. As tensions rise between China and the west, US politicians are seeking to slow down investment in the rival superpower, proposing legislation to make it more difficult for drugs licensed from Chinese biotechs to be sold and approved in the US.
Industry experts caution that such moves are unlikely to materialise soon, but the possibility is a clear concern. Soriot says the challenge is to “tap into the innovation” in China while “navigating the geopolitical environment and making sure to operate in a way that is acceptable to governments”. Last year the company announced a $50bn investment commitment in the US, and it became the first foreign drugmaker to strike a tariff-exemption deal with the Trump White House.
Soriot describes AstraZeneca’s R&D strategy as delivering on a “fundamental ethical and moral responsibility . . . to identify new treatments and bring them to patients”, who ultimately do not care about the origin of life-saving cancer drugs. “If a drug is invented in China,” he says, “people in the US and UK . . . that can be treated with new medicines will want the new medicines.”
An ambitious revenue target of $80bn by 2030, up from $58.7bn last year, is also contingent on growth in the US. Set in 2024, it is a further stretch from 10 years previously, when Soriot announced a goal of $45bn revenue by 2023.
Back then markets were sceptical, says Sean Conroy, an analyst at Shore Capital. But AstraZeneca delivered, an achievement Soriot credits with walking away from Pfizer and spending on R&D. “If we merged, it was going to disrupt our science,” he says. “Of course, there was a risk . . . But we thought we owed it to our employees, shareholders [and] patients to say no and to focus on our own pipeline.”
He says the company’s “defining focus” remains on “science and recruiting the best people”, in R&D but also “the commercial side . . . Our medicines only make a difference if they are brought to physicians.”
AstraZeneca is now among the largest spenders in the industry, ploughing $14.2bn, 24 per cent of revenue, into R&D last year. Last month it edged closer to joining the competitive field of weight-loss treatments after positive data from a mid-stage clinical trial of a pill the company is developing.
It has also made some well-timed acquisitions, notably the 2021 purchase of Alexion for $39bn, which allowed the company to launch a business in rare disease medicine, earning $9.1bn, 16 per cent of last year’s revenue.
The plan has not always delivered straightforwardly. When a combination drug for lung cancer failed a key trial in 2017, it wiped £10bn off the company’s value and led to questions from investors about the chief executive’s future. But the drug has since proved effective in treating other tumours, and last year brought in $6.1bn in revenue.
Soriot admits AstraZeneca would have been in “trouble” if such bets had failed to deliver. And the company needs its investments to keep paying off.
One setback came this week as its share price fell sharply on Thursday after a nerve disease drug failed to meet its target in a late-stage trial to treat a heart condition.
Three of AstraZeneca’s most valuable drugs lose patent exclusivity after 2030, opening nearly $20bn of sales to generic competition. The group is halfway to a target of launching 20 new medicines by 2030 to hedge against this. “Pharma companies constantly have to reinvent themselves,” says Conroy. “They will have to keep investing in R&D.”
Described as “mercurial” and as having an “edge” by one executive who previously worked for him, Soriot’s work ethic — one he describes as “casual intensity” — is well known. “He hates being at the office,” says the former executive. “He likes being on the manufacturing sites and understanding how things work from the ground.”
In the past year his pragmatism has sometimes challenged a relationship with the UK, where the company is based and regarded as something of a national asset. Soriot was knighted in 2022 for services to UK life sciences, and particularly its Covid-19 vaccine development work, which made it a household name.
But the decision last year to bring AstraZeneca’s US listing on a par with London and Stockholm sparked concerns a company considered a British crown jewel could eventually leave London. That compounded worries that investment in the UK was not keeping up with China and the US. The company ditched a vaccine plant expansion near Liverpool, after failing to reach an agreement with the government over the level of state support, and last year paused expansion in Cambridge and the development of a new lab in the northern English town of Macclesfield.
It said in April it would revive the Cambridge and Macclesfield projects following a UK-US trade deal, which Soriot described as “progress” and which included measures to increase NHS spending on medicines. He is adamant any AstraZeneca success in the US is a net positive for the UK, where it employs thousands of people. He has also been vocal about the UK — and the rest of Europe — needing to increase spending to compete with China and the US for investment, and to attract companies.
“There are many places around the world, including emerging markets, that want to do clinical trials and R&D, so you have a lot of competition,” he says, adding AstraZeneca works with almost every country globally. “If you do this, you have to find a way to work constructively with whoever is leading the country . . . From country to country, the political systems are different. At any time you can have a government that is left- or right-leaning.”
As for the leadership of AstraZeneca, Soriot acknowledges scrutiny over who might replace him, though shows no sign of slowing down.
“Everyone focuses on when am I going to retire,” he says. “I’m not running out of excitement . . . But of course biology will catch up with me at some point. That affects all of us and we have a great focus on succession planning like any good company should.”