FT : Singapore’s sovereign wealth fund blues

Singapore’s sovereign wealth fund blues

Singapore’s sovereign wealth behemoths confront lagging returns

Singapore is the envy of the world in many regards, from its 10-second airport clearance time to its numerous Michelin-starred street-food vendors.

But when it comes to sovereign wealth fund investment returns? Not so much.

Despite being an island nation of just 6mn people, Singapore boasts two of the world’s biggest and best resourced state-owned investors: Temasek and GIC.

The FT’s Owen Walker took a deep dive into the reasons for their poor performance and how the funds are trying to make their portfolios more resilient in the face of more volatile market conditions to come.

DD readers are likely aware of the two financial behemoths, as they frequently pop up in deals around the world, from Silicon Valley to Shanghai.


Yet each has averaged an annual rate of return of just 5 per cent over the past decade. That places them well within the bottom quartile of a cohort of 50 similar institutions around the world.

At the same time, their importance to Singapore’s economy cannot be overestimated. 

Contributions from Temasek and GIC — along with Singapore’s central bank — account for about 20 per cent of the city-state’s budget and have enabled it to maintain a surplus for much of the past two decades. 

Their performance will be even more critical as Singapore’s population ages and becomes more reliant on the state.

“Their fund performance is the elephant in the room that nobody wants to talk about,” said Diego López, managing director of Global SWF, who is based in the city-state.

WSJ : Apple Departures Point to Challenges for iPhone’s Dominance

Apple Departures Point to Challenges for iPhone’s Dominance
Four top lieutenants have left in the past 12 months while dozens of others defect to rivals

  • Apple is experiencing a wave of executive departures, including its general counsel and head of AI strategy.
  • Key Apple employees are defecting to rivals including OpenAI and Meta Platforms, contributing to a long-term brain drain.
  • Rivals are actively recruiting Apple talent and developing new AI devices to challenge Apple’s market dominance.

Apple AAPL -1.21%decrease; red down pointing triangle is facing a wave of executive departures as the company continues a period of transition, not only among its leadership but, if rivals have their way, for its business as well.

On Thursday, the company announced that its general counsel and head of policy will both retire next year. On Wednesday, a top designer left for Meta Platforms. On Monday, Apple said its head of artificial-intelligence strategy would retire. Its chief operating officer announced his retirement in July, and its chief financial officer has transitioned to a new role.

The executive departures underscore a changing of the guard under way at Apple, even as Chief Executive Officer Tim Cook himself shows no sign of stepping down. Cook and his new lieutenants face a critical test preparing Apple for the AI era and the wave of new competitive devices that result.

Further down the org chart, dozens of Apple employees have defected to OpenAI and Meta in recent months, part of a long-term brain drain that has robbed the company of innovators and seeded rivals with expertise they hope to use to dethrone the digital-device king.

Apple’s reign will continue as long as consumers access their online services on its device. And that dominion over the means of app distribution rankles other tech heavyweights who are trying to find ways to control their own destinies, including Mark Zuckerberg, Sam Altman and Elon Musk.

Zuckerberg this week hired Apple’s Alan Dye, a top Apple designer, after hiring away a handful of Apple’s key AI staffers during a recruiting blitz he embarked on as he sought to revamp Meta’s AI work. After his effort to create a “metaverse” to supplant the iPhone failed, he has now turned his attention to AI and smartglasses to achieve the same goal.

Altman paid $6.5 billion to “acqui-hire” Steve Jobs’s protégé Jony Ive, who helped build the iPhone and the Apple Watch, along with Ive’s team that comes with other ex-Apple heavyweights. They are planning an AI device that they hope will be the future of computing. The new hardware arm of OpenAI has been hiring aggressively from the iPhone maker recently as well.

Dozens of Apple engineers and designers with expertise in audio, watch design, robotics and more have decamped to OpenAI in recent months, according to a review of LinkedIn profiles.

Musk has at times considered building a smartphone himself owing to frustration with Apple’s dominance, The Wall Street Journal has reported. His social-media platform, X, is suing Apple because he is unhappy about the placement of his own AI app in the App Store.

None is an immediate threat. Consumers’ lives are on their iPhones. There isn’t yet a killer AI app that would make them move their digital selves, much less a device that offers it.

Yet without a coherent AI strategy of its own, one that can convince customers and employees that the company can play a meaningful role developing the defining technology of the decade, Apple is leaving an opening for rivals.

One executive still firmly encamped at Apple is Cook. Despite turning 65 last month, an age at which many CEOs are contemplating retirement, Cook hasn’t slowed down. He has demonstrated his value to shareholders again this year by deftly handling President Trump, beating back the threat of tariffs and returning Apple’s stock to record territory.

If he can deliver successful AI products before he departs, Cook can secure his legacy as one of the great tech executives, while giving his successor a running start.

News Corp, owner of The Wall Street Journal, has a commercial agreement to supply news through Apple services. It has a content-licensing partnership with OpenAI.

FT : Chinese challenger to Nvidia surges fivefold in market debut

Chinese challenger to Nvidia surges fivefold in market debut
Investors bet Moore Threads will benefit from Beijing’s drive to reduce dependence on US chipmaker

A Chinese chipmaker founded by a former Nvidia executive has surged fivefold in its market debut as investors bet on Beijing’s drive to reduce the country’s reliance on the US chip giant for artificial intelligence needs.

Beijing-based Moore Threads raised Rmb8bn ($1.1bn) in its listing on Shanghai’s tech-focused Star Market on Friday, marking the second-largest mainland initial public offering this year.

Shares of mainland Chinese chipmakers and chip designers have soared this year as investors bet on Beijing’s efforts to create a local supply chain for components crucial to the AI boom.

Washington has barred Nvidia from selling its most advanced AI processors in China, while Beijing has instructed its tech companies to transition away from the products.

Founded in 2020 by Zhang Jianzhong, a former senior Nvidia executive in China, Moore Threads is viewed as a second-tier domestic chipmaker, lagging far behind Huawei and chip designer Cambricon in market share.

Analysts at Bernstein estimate Moore Threads will sell $58mn worth of chips this year, compared with roughly $10bn each for Huawei and Nvidia.

By 2026, Huawei’s sales are forecast to rise to $12bn, representing about half of China’s AI chip market, while Moore Threads is projected to generate $93mn.

Nvidia’s China sales are expected to plunge to $2bn next year, with its market share sliding from 40 per cent in 2025 to 8 per cent amid Washington’s curbs.

Lawmakers are debating whether to allow Nvidia to sell its less advanced H200 chips in China, with advocates of the move arguing the US should keep Chinese tech companies dependent on American technology to entrench its leadership in AI.

The lossmaking Moore Threads secured fast-track approval to list after regulators this year eased profitability requirements for companies seeking to float on the Star Market, in an effort to boost capital raising for strategic sectors.

The company, backed by venture capital firm HongShan, formerly Sequoia Capital China, designs graphics processing units, initially for gaming but now adapted for training large language models used in AI — a trajectory mirroring Nvidia’s.

By contrast, Huawei and Cambricon primarily develop application-specific integrated circuit chips, which were originally optimised for narrower computer vision applications before being re-engineered for generative AI work.

There has been a shortage of Chinese-made AI chips this year because of constrained capacity at domestic plants.

Moore Threads was added to the US entity list in October 2023, cutting off its access to Taiwan Semiconductor Manufacturing Company, which produces most of the world’s AI chips.

The company has since moved manufacturing to mainland Chinese contractor Semiconductor Manufacturing International Corporation, which has lower chip yields and more expensive production processes.

Moore Threads is the first in a series of AI chipmakers expected to go public in either Hong Kong or mainland China. MetaX recently won approval to list on Shanghai’s Star Market. Biren and Enflame are also planning to go public in Hong Kong.

FT : F1 bets big on long-term race promoters

F1 bets big on long-term race promoters
As Grands Prix become multimillion-dollar mega-events, long-term contracts with cities and authorities are now the norm

Earlier this year Stephen Ross, owner of the Miami Dolphins NFL team, renewed a deal with F1 to host the Miami Grand Prix on a circuit around his stadium until 2041. Few were surprised by the length of the deal, such has been the recent growth in F1’s popularity: the sport has a global fan base of more than 827mn, a 63 per cent increase since 2018, and slots on the 24-race calendar are extremely scarce. The resulting trend has been for most promoters — the organisations that arrange the individual races at each venue — to strike long-term contracts, to 2035 and beyond.

F1 Grands Prix are now far more than sporting events; they combine entertainment, gastronomy and culture, over four days. The Las Vegas Grand Prix generated $934mn in economic impact in 2024, attracting more than 300,000 fans, and in just three years it has become the city’s largest annual event. The Brazil race this year brought an economic impact of R$ 2.3bn ($425mn) to the city of São Paulo.

“These are mega projects. They require major investment but, on the flip side, they are generating phenomenal economic return,” says Louise Young, director of race promotion at F1. “These are projects which sustain supply chains, communities and economies locally. These are, in many cases, the biggest events that happen in these countries or cities, and they become attached to the time of year that they’re scheduled.”

The F1 calendar comprises 24 races in 21 countries. The Americas host six, with Austin, Montreal, Mexico City and São Paulo alongside Miami and Las Vegas. There are four in the Middle East: Bahrain, Abu Dhabi, Qatar and Saudi Arabia. Further east are Japan, Singapore, China and Australia, then Europe.

“For now, we think 24 is the right number of events for us, for the teams, for the quality of our product,” says Young. “We don’t see growth in the promoter business coming necessarily out of more events. We see growth around optimisation and changes to the calendar.

“It has been mooted that there will be rotation in the future, perhaps some rationalisation about our presence in Europe,” Young adds. “We hope to add perhaps one more destination in Asia. There are a number of prospects in Africa; we hope to find a partner who can be that long-term stable presence.” Although growth in the US market remains F1’s main priority, it has no current plans to add races there. 

For promoters such as Miami and Silverstone, home of the British Grand Prix, which has a contract to 2034, long-term agreements make for better investment planning.

“It allows us to continue to invest in F1 and for F1 to continue to invest in their US strategy. Miami is a key piece of that strategy for them,” says Kathy Nowak, president of the Miami GP.

“When we’re planning, dreaming up different things we can do, we’re thinking about the next 16 years, rather than the next five.

The biggest challenge we have, which is unique, is we don’t just operate a circuit. We operate a venue that’s active almost 365 days a year with different events,” Nowak adds. “So if we were to go permanent on any type of structure, we need to contemplate the use of that 365, given that we also do Dolphins, soccer, concerts and Open tennis.”

Next year Nowak and her team will have a tight turnaround after the Grand Prix in May to be ready to host matches in the Fifa World Cup. “We start building the Grand Prix in January, and all the temporary structures need to be out before June 1, because Fifa is loading in,” Nowak explains.

There is significant diversity between F1 promoters, from big sports businesses such as the Dolphins, to automobile clubs in Monaco and Italy, and government agencies in Melbourne. This diversity contributes to the individuality and unique character of each Grand Prix, something F1 and its owner Liberty Media value highly. When it acquired the sport from CVC Capital Partners in 2017, Liberty’s management team saw the financial stability and growth of promoters as a key priority. 

“[We believed that] to have our promoters grow and benefit from the ecosystem would in turn pay dividends,” says Young. “We want promoters who are ambitious, who are investing, who have an eye to the future and want to grow the fan base domestically and internationally. Our success is the promoter’s success and vice versa.”

Stuart Pringle, chief executive of Silverstone Circuit, had extensive experience of dealing with Bernie Ecclestone, F1 chief executive under CVC’s ownership, when promoters would come and go, and sometimes go out of business. “Liberty values the relationships with promoters — [investing] more time into working together and collaboratively growing the product for the benefit of the fans,” he says. “It feels far more collaborative nowadays.

“Longer contract length gives promoters long-term certainty and confidence to invest in facilities and grow relationships with local partners. In our case that is ‘Destination Silverstone’ and future motorsport talent, in our karting and young driver programmes or young engineers in education programmes based at Silverstone.”

Promoters are finding that the profile of their customers is changing, with 43 per cent of the total fan base now under 35 and 42 per cent of them female.

“Our audience tends to lean younger and we’re seeing more female audiences,” says Nowak of the Miami GP. “We’ve got newer fans, coming to experience the party, the festival likeness of the event. You’re going to see world-class racing action on track. But you’re also able to leave your seats and experience Miami through the food and beverage, through the entertainment. We’re catering to that younger fan looking for an all-day experience.”

FT : AI investing looks beyond the Magnificent Seven

AI investing looks beyond the Magnificent Seven
Many investment trusts opt for less obvious routes into the boom

Retail investors with AI holdings are probably in two minds now. Tech stocks continue to hit record highs, but there are also fears they are overvalued. For those looking to diversify their portfolio but still stay invested in AI, investment trusts offer a number of options. 

Magnificent Seven tech stocks are the most obvious way to access AI. The companies have been increasing spending on AI infrastructure and their share prices have shot up as a result. Well-known investment trust giants such as Scottish Mortgage, on a 12 per cent discount, have long been fans of tech companies, holding positions in listed companies including Amazon, Nvidia and Meta. 

But investment trusts are also seeking to access AI through less obvious companies or are capitalising on the boom via other routes.

Will Crighton, an investment trust analyst at Stifel, also recommends Polar Capital Technology, at an 11 per cent discount, and Allianz Technology, at 10 per cent, for their diversity.

“Both trusts are becoming more underweight to the Magnificent Seven and are looking to find the less well known winners,” he says. Both trusts have outperformed the Dow Jones World Tech index this year after a period of underperformance, but are still on discounts, which he argues is because investors have preferred to access tech stocks through passive funds. “We feel the case for active over passive in this area of the market is growing,” he says.

Elliott Hardy, an investment trust analyst at Investec, adds RIT Capital Partners, on a 24 per cent discount, to this list, arguing that it offers investors access to big tech companies but also private companies such as OpenAI, and balances out both of these areas through uncorrelated investments like government bonds.

An alternative route is HG Capital, a private equity trust, which invests in software that helps companies manage their accounting and HR systems. That software is being given a big boost by AI, according to Luke Finch, a partner at the trust.

He thinks HG Capital is reasonably well-placed in the case of a bubble bursting as it is one layer removed from the infrastructure spending at the tech giants. The trust currently trades at a 10 per cent discount.

Matt Hose, an investment trust analyst at Jefferies, recommends Pantheon Infrastructure, at a 15 per cent discount, and Cordiant Digital Infrastructure, at a 26 per cent discount, as alternative options for investors looking to access data centres in Europe.

A smaller company option is the Aberdeen Asia Focus investment trust, at a 13 per cent discount, which invests in Asia’s AI supply chain among other themes. Gabriel Sacks, manager, says that the trust takes advantage of the fact that while the US dominates chip design, it relies heavily on Asia for chip manufacturing. Chroma ATE, one of the trust’s holdings, provides equipment and services to stress test semiconductors for Nvidia and quality control for TSMC. 

One question for investors buying an investment trust at a discount is whether it will ever narrow, with the sector struggling for some time now to close discounts. Hose at Jefferies thinks the outlook is “a bit more positive than it has been”, pointing to activist interest in the space, and argues that those with AI exposure should do better than the pack. 

Of course, there are plenty of investment professionals who do not believe the market is in a bubble. Those include Ben James at Baillie Gifford, who thinks that AI will affect every investment. “AI is a general-purpose technology, everything will be exposed to it at some level.”

“The big thing that is being missed by many in the market now is that most of the focus and debate is on spend, whereas the focus should actually be on the capability enhancements generative AI tools are having at companies. Companies are doing things now that they couldn’t do before,” he says.

Ben Rogoff, manager of Polar Capital, is also a defender of market enthusiasm. His trust mainly focuses on so-called enablers: companies providing the computing, networking and power infrastructure for AI. But he thinks that Big Tech will start to lose its market dominance of AI in the coming years, offering opportunities for investors to find less obvious winners. 

“Where others see an AI bubble, we believe we are in year three of a multi-cycle infrastructure build required to support what we consider the next general-purpose technology,” he says. “AI is not just another theme; it is the defining technology of this decade,” he argues.

FT : Billionaire Drahi comes out fighting as creditors fall through ‘trap doors’

Billionaire Drahi comes out fighting as creditors fall through ‘trap doors’
Lenders to Franco-Israeli tycoon’s Altice empire are guessing his next move after falling victim to an aggressive restructuring

For the past few years Patrick Drahi has had his back against the wall. The end of the low-interest-rate era turned the screw on the buccaneering billionaire, who had loaded up his Altice telecoms empire with more than $60bn of cheap debt.

But in the aftermath of last week’s Thanksgiving celebrations Drahi launched a fightback that stunned Altice’s many creditors, who were served up a turkey of a restructuring they neither expected nor wanted.

Altice International, a subsidiary that owes more than €8bn, stripped assets away from creditors in a transaction regarded by European debt investors as one of the most aggressive in living memory.

That came swiftly after Altice US, which sits on more than $26bn of debt, initiated legal action against creditors. Some of the world’s most powerful asset managers, including Apollo and BlackRock, stand accused of colluding to force it into bankruptcy.

Drahi’s aggressive debt issuance over the past two decades has earned the Franco-Israeli industrialist royalty status in the junk bond market.

That codependence, and a comparatively amicable restructuring agreed with lenders to Drahi’s French business in February, had raised hopes that creditors to other corners of an empire that stretches from the US to Portugal and Israel could escape with limited losses.

But last week’s events have underlined that the 62-year-old telecoms tycoon has no intention of easing the pain for the institutions that fuelled his growth, as he aims to wriggle out from under a mountain of debt.

“People thought he [Drahi] was aggressive in France, but he has seemingly ratcheted it up a notch,” said New Street Research analyst Russell Waller.


Drahi built his telecoms empire off the back of heavy borrowing at low interest rates, notably raising $16.7bn in the largest ever high-yield bond deal to finance a takeover of SFR, one of France’s main telecoms providers, in 2014.

But in the current higher rate environment Altice has been forced to consider widespread asset sales to reduce its debt pile.

An unpredictable situation was further complicated by the arrest of Drahi’s longtime lieutenant, Armando Pereira, on suspicion of defrauding the company in 2023. Pereira denies wrongdoing.

French authorities intensified their probe last month, raiding companies and properties across the country to gather evidence of what the prosecutor described as a “vast, corrupt system” that operated to the detriment of Altice.

Drahi’s battles with creditors are taking place against the backdrop of a potential dismantling of his wider empire. He has already rejected a €17bn bid for French mobile operator SFR and is expected to receive offers for Altice’s €7bn French fibre network XpFibre early next year. Several approaches for Altice Portugal have so far failed.

Signs of what was to come for creditors to Drahi’s US business began to emerge when Altice hired law firm Kirkland & Ellis, which has a reputation for advising companies to deploy hostile restructuring tactics.

The litigation launched last week was the first instance of a company alleging creditors violated US antitrust law in a debt restructuring. Many of the lenders in that group — which also includes Ares Management and Oaktree Capital — are exposed to multiple Altice entities.

Drahi’s next salvo came just days later, when Altice International announced that it would be shifting assets that contribute about 80 per cent of its €1.6bn of earnings out of the creditors’ pool of collateral, in a transaction known as a “drop down”.

One high-yield bond investor said the move was “really pushing the frontier” of such transactions, which designate subsidiaries as “unrestricted”.

Drahi’s lieutenants had in February threatened to restructure its French business in a similar fashion, but ended up backing down and agreeing to a deal that involved handing a 45 per cent stake in the company to creditors, in exchange for a substantial debt writedown.

Lenders to Altice’s Luxembourg-based international business, where creditor protections are weaker than in France, were ultimately more vulnerable to aggressive action.

In the aftermath some of Altice International’s top ranking bonds fell by as much as 12 per cent on Monday morning, from 75 cents on the euro to 66 cents. Two of its junior bonds fell from around 35 cents on the euro to just over 16 and 19 cents respectively.


An Altice bondholder said that by suing US creditors Drahi was sending a “warning” to the lenders to the group’s international business, who are being advised by US law firm Gibson Dunn.

Drahi “wants as big an impact on the [bond] price as possible and to scare investors as much as possible,” the bondholder said.

The man pulling the strings for Drahi in his latest restructuring is Dennis Okhuijsen, a hard-headed lieutenant who handled the negotiations with creditors to Altice France, according to two people familiar with the matter.

“Dennis is the guy who levered up all of Patrick’s assets and who put the debt structures in place — he is now back to help unravel it all,” said an executive familiar with the arrangements.

The person added that Okhuijsen is helping Drahi use all the “trap doors” he built into the agreements, at a time when bond investors’ discipline on enforcing strict covenants was weak.

After falling through those trap doors creditors are scrambling to figure out Drahi’s next move. Top of mind is understanding whether the billionaire will use his newly liberated assets to raise more debt, pay himself a dividend or sell them entirely.

Waller at New Street Research believes Drahi’s gambit was likely an attempt to force lenders to come to the table and agree a restructuring, in effect a new spin on the same tactics Drahi deployed in France.

By moving Altice’s Portuguese and Dominican operations outside of the restricted group, creditors have been left with about €300mn of earnings underpinning their €8bn of debt.

“That is clearly unsustainable,” Waller said. “He will probably move those assets back into the restricted group and in return, creditors will agree to a write down.”

As well as moving the assets away from creditors, Altice announced that its Portuguese business had raised €750mn of new debt through “a private financing transaction” to pay upcoming liabilities of the wider international business, as well as for general working capital purposes.

Altice International also said that it could raise another €2bn of new debt at Altice Portugal to follow the transaction.

CreditSights analyst Mark Chapman said Drahi holds “most of the cards, with limited scope for the creditors to fight back hard”.

But one industry executive reckons they will not go down without a fight.

“It’s going to end up in court . . . it will go on and on and on,” he predicted, adding that while Drahi will still “have his yacht and have a billion in the bank”, he may end up as somebody “nobody wants to lend any money to”.

FT : Why French leveraged buyouts are caving in like camembert

Why French leveraged buyouts are caving in like camembert
Debt restructurings feel more like a biennial standing appointment rather than a one and done

Corporate crises come in cycles. But France is proving that some loops are stubbornly hard to break. There are a lot of companies sliding into distress and entering restructurings — many not for the first time.

Corporate bankruptcies in France have reached an all-time high of 68,227 cumulatively over the past 12 months to September. While France is about 16 per cent of European GDP, its companies account for about 30 per cent of all the distressed loans — those trading below 90 cents on the dollar — in Morningstar’s European Leveraged Loan Index.

Just last week, lenders prepared to take control and inject equity into care-home operator Colisee while retail giant Casino proposed its second restructuring, with a potential €300mn of fresh equity from majority shareholder Daniel Křetínský, in less than two years.


In part, French companies simply have a lot of debt. The country has been a particularly fruitful hunting ground for private equity, with 4,675 leveraged buyouts since 2015, according to analysis by HEC business school, compared with 2,786 in Germany and 1,749 in Italy. Some targets of past acquisitions, such as Apollo-owned chemical maker Kem One and payment-terminals provider Ingenico, are buckling under higher interest rates.

The sorry state of the French economy — with high debt and growth at a miserly 0.7 per cent of GDP this year — does not help domestically-focused businesses. Partners Group’s property business Emeria’s unsecured debt is trading at around 50 cents on the euro, a sign that investors are bracing for losses as the credit becomes riskier. It also means that the French government is keen to cut costs, squeezing companies that depend on public spending, such as those in the healthcare sector.

Laboratory companies, for instance, rely on the government to pay for routine medical testing. The average price for medical testing has fallen more than 20% between 2015 and 2023, and is expected to decline again from 2026. That’s bad news for the likes of EQT-owned Cerba Healthcare, which racked up a €4bn debt pile through post-Covid acquisitions and whose unsecured bonds are trading at 13 cents on the euro.

There are two ways of bringing French corporate distress back down to manageable levels. The first is to stop adding to the pile, and the second is to clean out the existing backlog. It is not clear that either are happening, however.

The amount of total debt piled on to companies during buyouts may have fallen slightly, from nearly 6 times trailing ebitda in October 2021, says PitchBook LCD, to 5.7 times in the past year. But that’s still far above the debt loaded on to German LBOs at 4.33 times, and the UK’s 5 times. And debt restructurings, in France and elsewhere, feel more like a biennial standing appointment than a one and done. This cohort is unlikely to fix itself up for good.

FT : Lab-grown genomes set to transform human DNA

Lab-grown genomes set to transform human DNA
Research shows synthetic chromosomes can be transferred to human cells with potential to improve viral resistance

Scientists in the UK have taken the first steps in a new programme to create whole human genomes from laboratory chemicals, which they say could eventually transform biology and medicine.

It will allow human DNA to be altered on a scale that is not possible with the more limited gene-editing techniques available today, and could be used for many applications such as making human cells resistant to viruses or altering the immune system.

The £10mn Synthetic Human Genome Project, funded by the Wellcome Trust, has successfully demonstrated that a synthetic chromosome can be transferred to a human cell.

It is a “landmark step for synthetic biology”, said James Collins, professor of medical engineering at Massachusetts Institute of Technology, who is not involved in the project. “This work lays essential groundwork for the engineering of synthetic human genomes and the transformative applications that will follow.”

The research strategy, described in the journal Science, involves first assembling a synthetic human chromosome — the DNA structure carrying genetic information — inside a mouse cell.

The synthetic chromosome is then transferred into a human cell in place of one of the original chromosomes. The nucleus of a human cell contains 23 chromosome pairs with one set inherited from each parent.


Programme leader Jason Chin of the Ellison Institute of Technology at Oxford university and colleagues at the MRC Laboratory of Molecular Biology in Cambridge have previously pioneered the creation of microbes with synthetic genomes to make new materials that natural bacteria cannot produce.

But building a human genome requires a different strategy, said Chin. “It is 1,000 times larger than a bacterial genome — and a human cell contains two copies of each chromosome, so it is hard to engineer the DNA in one copy without affecting the other one,” he said.

To do this, the team uses a mouse embryonic stem cell as the “assembly cell” in which a human chromosome is engineered, he explained. “We are moving chunks of synthetic DNA to replace the corresponding chunks on the human chromosome inside the assembly cell.”

The experiments showed that the synthetic chromosome could be transferred to a human cell to replace one of the two natural chromosomes without causing damage. The whole process can be repeated and the second natural chromosome expelled to produce a human cell with two synthetic chromosomes.


Several years of development and safety evaluation will be required before the technology is ready to use in medicine. One possible application is to make human cells resistant to viruses, such as by repopulating the liver of immunocompromised patients to prevent them picking up infections, said Chin. “Another is to make cells with synthetic genomes precisely tailored for a particular type of cellular therapy.”

In the more immediate future, the synthetics genomics programme will provide new biological insights, Chin said. For example, the experiments have already shown that the DNA caps on the end of a human chromosome called telomeres grow up to 10 times longer when it is transferred to a mouse cell and then shrink back to their original size when put back into a human cell.

Although the Synthetic Human Genome programme does not envisage any outlandish experiments to transform human DNA for purposes that people might find objectionable, such as enhancing intelligence or physical appearance, it has set up a wide-ranging project with the University of Kent to examine the ethical, social, economic and policy implications of genome synthesis.

FT : Friedrich Merz jets to Belgium to secure frozen Russian assets plan

Friedrich Merz jets to Belgium to secure frozen Russian assets plan
German chancellor has been driving force behind EU plans for reparations loan to Kyiv

German Chancellor Friedrich Merz is making a last-ditch bid to secure crucial Belgian support for an EU plan to use frozen Russian sovereign assets to fund European military aid to Ukraine.

Merz will travel to Brussels on Friday to dine with Belgian Prime Minister Bart De Wever, who has become the biggest obstacle to a so-called reparations loan for Kyiv backed by the assets. European officials are rushing to get backing for the plan before leaders debate the proposal at a summit in two weeks.

“It is a race against the clock,” said a German government insider. Another added: “Merz thinks it is on his shoulders to carry this over the line.”

The meeting comes days after European Commission president Ursula von der Leyen unveiled legal proposals for the loan, which controversially rely on emergency powers in EU treaties to keep Russian assets frozen indefinitely, and push the loan through while bypassing potential national vetoes.

Merz supports the proposal and use of the Article 122 emergency powers, even if Belgium remains opposed, according to people familiar with his position. A spokesman for the German government declined to comment on the message Merz intends to deliver to de Wever.

In order to attend, the German leader rescheduled his first state visit to Norway, where he had been due to meet the King as well as Prime Minister Jonas Gahr Støre. Von der Leyen will also take part in the Brussels dinner. 

Writing in the Financial Times in September, the German chancellor endorsed leveraging about €210bn of Russian central bank assets immobilised in Europe for Ukraine. That marked a reversal from earlier scepticism, driven partly by fears it could undermine confidence in the euro, according to people with knowledge of his thinking.

“He is taking a high risk and throwing his whole weight behind it,” said Carlo Masala, professor of international relations at the Bundeswehr University Munich. “It shows how serious he is about the issue.”

Belgium and Brussels-based Euroclear, a clearing house which holds most of the assets, have threatened to block the plan without “cast-iron” guarantees that the other EU countries would also bear the brunt of any financial burden or retaliation from Moscow. 

Several countries, including France, have balked at issuing national guarantees for the loan, needed in case Euroclear is required to return the assets to Moscow. The European Central Bank has declined to provide emergency liquidity to Euroclear should those guarantees be triggered.  

Recent talks over a deal to end Moscow’s war on Ukraine have injected fresh urgency into the debate. Merz and other European leaders, who were excluded from the US-Russia negotiations, were alarmed to discover that the discussions touched directly on the Russian sovereign assets held in Europe, according to several people close to the chancellery.

Norbert Röttgen, a senior MP from Merz’s CDU party, described the decision on Russian assets as “Europe’s moment of truth”. He added: “If we can’t do this [the reparations loan], then what does it say about Europe’s sovereignty and all that talk about strategic autonomy?”

For Berlin, the need to secure the assets quickly and send a political signal to Moscow and Washington now outweigh legal caution, the people said. While Berlin has urged the commission to address Belgium’s concerns, it believes that there is no alternative to the loan to keep Ukraine solvent.

Germany’s push is also partly driven by concerns that the country, which has relaxed its debt brake to allow virtually unlimited spending on defence, risks having to shoulder most of the cost of supplying Ukraine with military equipment.

“We will end up paying the bill,” one of the people said.

>>> US After Hours Summary: RBRK +15%, COO +12%, ULTA +6.4% higher on earnings;

After Hours Summary: RBRK +15%, COO +12%, ULTA +6.4% higher on earnings; AGX -10.9%, HPE -9%, S -9% lower on earnings

After Hours Gainers:

Companies trading higher in after hours in reaction to earnings/guidance: RBRK +15%, COO +12% (also names new Chair; also strategic review), ZUMZ +11.2%, CHPT +10.4%, ULTA +6.4%, TTAN +5.6%, SWBI +2.7%, SFIX +2.1%, IOT +1.9%

Companies trading higher in after hours in reaction to news: PRAX +21.1% (completes pre-NDA meeting with FDA; also results from EMBOLD study), NFE +19.3% (final approval for 7-yr gas supply agreement), VNDA +8.1% (FDA lifts partial clinical hold on protocol VP-VLY-686-3403), FOSL +6.6% (Director bought 28170 shares at $3.62 worth ~$102K), CAPR +5.3% (stock offering), WKC +1.1% (additional $150 mln to share repurchase authorization), WEC +0.5% (plans to raise dividend; also provides guidance), CRM +0.1% (AstraZeneca (AZN) selects Agentforce Life Sciences for customer engagement)

After Hours Losers:

Companies trading lower in after hours in reaction to earnings/guidance: DOMO -11.8%, AGX -10.9%, HPE -9%, S -9% (also CFO transition), DOCU -6%

Companies trading lower in after hours in reaction to news: TARA -12.5% (stock offering), IEX -8.9% (names new CFO), OKLO -7.8% (equity distribution agreement up to $1.5 bln), BLNK -7% (files for 14,814,814 share stock offering), SOFI -5.7% (stock offering), MTUS -4.4% (reaches agreement with United Steelworkers Local 1123), CVLT -3.1% (CFO to step down), AIR -1.9% (names interim CFO), WALD -1.6% (stock offering by selling shareholders), SKYT -1.6% (mixed shelf offering), RDNT -1.3% (mixed shelf offering), FDS -1.2% (trusted market intelligence available via Amazon Quick Research), PTC -1% (names new CFO), OC -0.9% (increases dividend), NB -0.5% (acquires scandium alloy assets), PLTR -0.2% (Northslope deepends partnership with PLTR), DAR -0.2% (to sell production tax credits), EMN -0.1% (increases dividend)