>>> Europe : Brokers Upgrades & DOwngrades - 25th of Sept. 2017

>>> Up
* Colgate Raised to Overweight at Morgan Stanley, PT $84
* Tullow Raised to Hold at Stifel, PT 180p
* Under Armour Raised to Overweight at Keybanc, PT $20
* Wacker Chemie Raised to Buy at Berenberg

>>> Down
* Autogrill Cut to Hold at Kepler Cheuvreux, PT EU11.30
* Countrywide Cut to Underperform at Credit Suisse, PT 111p

>>> Initiation
* BMW New Neutral at Bryan Garnier, PT EU89
* Cairn Energy New Buy at Peel Hunt, PT 240p
* Daimler New Buy at Bryan Garnier, PT EU87
* Fabasoft New Hold at M.M. Warburg, PT EU11
* Peugeot New Sell at Bryan Garnier, PT EU19
* Renault New Buy at Bryan Garnier, PT EU99

>>> Call

>>> Asian Update

Asia Mid-Session Market Update: New Zealand and German election results rattle the fx market; Japan said to eye ­¥2T supplementary budget

***Asia Summary***
- Asian equity markets opened mixed, solar names in China and South Korea weighed on indexes after ITC ruled imported solar panels are crippling American manufacturers. Election results in New Zealand saw ruling National Party with 46.6% and Labour with 35.5%. With neither party winning enough seats to have a majority in parliament, will have to use nationalist New Zealand First Party to form a coalition. This uncertainty sent NZD/USD into a tail spin, falling over 1% to 0.7252. The kiwi is expected to remain volatile until all votes are tallied by Oct 7th and a govt is formed.

- In Germany similar results happened with the election, Chancellor Merkel's party finishes 1st (32.8%) with opposition SPD with (20.4%). So she will again need to form a coalition. Notably, like elections around the world, the nationalist party took a notable part of the vote (13%) which will see the AFD Party enter parliament for first time. EUR/USD was slightly weaker, 1.1898.

- Japan PM Abe to hold press conference at 09:00GMT, no topic given but widely expected to announce a snap election, though a recent poll shows public is not in favor of one.

- Indonesia 10-yr yield fell 15bps to 6.27%, the lowest level since June 2013. Onshore yuan fell to lowest intraday level in September after PBOC cut the fixing to the weakest since Aug. 31. The Hong Kong dollar overnight interbank rate fell 21bps (the most in three week) to 0.19464%.

***Key economic data***
- (JP) Japan Sept Prelim PMI Manufacturing: 52.6 v 52.2 prior (4-month high)

***Speakers and Press***
China/Hong Kong
- (CN) Eight China cities, including Shijiazhuang, Chongqing, Nanchang, Nanning and Guiyang imposed curbs on home resales as part of campaign to cool home prices
- (CN) China Tangshang City to cut steel capacity by 50% in order to lower pollution levels; effective Monday – US financial press
- (CN) China Academy of Fiscal Sciences chief Liu Shangxi: China will push fiscal reforms that could boost revenues for local governments after next month’s key party congress

Korea
- (KR) North Korea Foreign Minister Ri Yong Ho: Pres Trump has made our rockets' visit to the entire U.S. mainland inevitable by nicknaming Kim Jong Un "rocketman" - UN speech

Japan
- (JP) Japan PM Abe said to seek ¥2.0T economic package plan; Package is meant to be in effect from FY18/19 - Japan press
- (JP) Support for ruling LDP Party at 44%, ahead of opposition; Abe cabinet support up 4 pct points to 50% – Nikkei Poll
- (JP) According to Kyodo poll nearly Two-thirds of Japan voters oppose PM Abe calling snap election - financial press

New Zealand
- (NZ) New Zealand Election Results: Ruling National Party 46.6%; Labour 35.5%; neither party wins enough seats to have a majority in parliament, will have to use nationalist New Zealand First Party to form a coalition
- (AU) Australia PM Turnbull: To impose extra controls unless LNG exporters set up domestic supply
- (AU) Australia Energy Market Operator: Expect east coast gas supply shortfall to intensify next year, expects the shortfall to be as much as 107 petajoules - Australian

Europe
- (DE) Germany exit polls suggest Merkel's party finishes 1st in German election; anti-migrant party to enter parliament; AFD Party to enter parliament for first time - tweet by financial press

***Asian Equity Indices/Futures (00:00ET)***
- Nikkei +0.4%, Hang Seng -1.2%; Shanghai Composite -0.3%, ASX200 +0.2%, Kospi -0.6%
- Equity Futures: S&P500 -0.1%; Nasdaq100 -0.0%, Dax -0.2%, FTSE100 -0.1%

***FX ranges/Commodities/Fixed Income (00:00ET)***
- EUR 1.1960-1.1898; JPY 112.53-111.93; AUD 0.7973-0.7942;NZD 0.7362-0.7252
- Dec Gold -0.0% at $1,297/oz; Nov Crude Oil -0.3% at $50.52/brl; Dec Copper -0.3% at $2.95/lb
- (PH) Philippines to issue PHP500B in treasury bills in 2018 v PHP327B in 2017 - local press
- (CN) PBOC OMO: To inject CNY200B in 14 and 28-day reverse repos v injected CNY120B in 7 and 28-day reverse repo prio
- USD/CNY (CN) China PBOC sets yuan reference rate at 6.5945 v 6.5861 prior (weakest setting since Aug 31st)
- (KR) Bank of Korea (BOK) sells KRW0.7T v KRW0.7T indicated in 1-yr monetary stabilization bonds; avg yield 1.54% v 1.50% prior

***Equities notable movers***
Australia/New Zealand
- FCG.NZ Reports FY17 (NZ$) Net 745M v 834M y/y; EBIT 1.12B v 1.43B y/y; Rev 19.2B v 17.2B y/y; +0.2%
- PEP.AU Gets improved and final proposal form KKR at A$3.70/shr for cash and special dividend; +4.6%
- BLY.AU Third day of losses, -26%

Japan
- 7211.JP Planning to launch electric SUVs in Japan, US and Europe in early 2020s – Japanese Press; +4%

>>> Alitalia has EasyJet/Elliot consortium and Lufthansa in pole position to acq

Alitalia has EasyJet/Elliot consortium and Lufthansa in pole position to acquire aviation assets
Alitalia has a consortium made up of Elliott and EasyJet [LON: EZJ] and Lufthansa [ETR: LHA] in pole position to acquire its aviation assets, Italian language daily Il Messaggero reported.
The unsourced report said that that the auction for the aviation assets has become a two-horse race between the consortium and Lufthansa after Ryanair [RYA:LN] had to cancel 2,100 flights due to staff shortages.
The report said that the mass cancellations have led to doubts in Italian government circles about Ryanair's aggressive market approach.
The report noted that administrators for Alitalia are looking to close a deal for the sale of the aviation assets by 5 November.

>>> ACS officially confirms its interest in bidding for Abertis

ACS officially confirms its interest in bidding for Abertis

Spanish construction group ACS [BME:ACS released the following significant event to the Spanish stock-market regulator CNMV, on 22 September confirming it is considering bidding for Abertis [BME:ABE] :
In relation to the news appearing in the press and as a continuation of significant event 254782 released on 21 July 2017, ACS confirms that:
  • It keeps studying making an offer for Abertis with the assistance of external advisors, having held meetings with potential investors and financial entities, without having taken any final decision on the matter.
  • The issue has not been submitted to deliberation or approvasl to the BoD
  • Among the studied possibilities, it has been considered the fact that the IPO be carried out with participation of Hochtief AG

>>> What to look at this Week End - 23rd & 24th of September 201

Weekly Performance
Dow +0.36% S&P +0.06% Nasdaq -0.33% Russell +1.33% Mexico +0.78% Brazil -0.48% Nikkei +2.47% Hang Seng +0.26% Shanghai -0.03% Shenzen +0.03% EuroStoxx +0.74% FTSE +1.32% CAC +1.29% Dax +0.59% Ibex -0.12% MIB +1.36% SMI +1.20%
Equities held steady this week as investors digested the latest FOMC policy directive, which was released on Wednesday afternoon. The major indices ticked up to new record highs in the first half of the week, but faltered a bit on the back nine. The S&P 500 ticked up 0.1% while the Dow (+0.4%) did a little better and the Nasdaq (-0.3%) did a little worse.
The Fed's latest policy directive came in pretty much as expected. The FOMC unanimously voted to leave the fed funds target range at 1.00%-1.25% and announced that it will start its balance sheet normalization process in October. Meanwhile, the Fed's so-called "dot plot" was unchanged from the one released in June, showing that the median FOMC member still anticipates an additional rate hike in 2017 and three rate hikes in 2018. Within the equity market, the heavily-weighted financial sector (+2.7%) finished near the top of the sector standings, benefiting from the prospect of heightened interest rates and some sector rotation. The financial group has trailed the broader market for much of the year, but has been making a come back over the last two weeks; the sector has added 6.9% since September 7.
The telecom services group (+3.8%) also put together a solid performance this week, trimming its year-to-date loss to 8.5%, amid reports that Sprint (S) and T-Mobile US (TMUS) are nearing a merger deal after more than four months of on-and-off talks. The two companies settled the week with gains of 10.8% and 4.7%, respectively. On the flip side, the top-weighted technology sector (-0.7%) underperformed, thanks in large part to Apple (AAPL), which dropped 5.0%. There were rumors of softer-than-expected demand for the new iPhone 8, which hit stores on Friday, but this week's slide was also likely due to some end-of-quarter profit taking following yet another solid three-month stretch for the company. AAPL shares will enter Monday's session with a quarter-to-date gain of 5.5% and a year-to-date gain of 31.1%. Countercyclical groups like health care (-1.2%), consumer staples (-2.3%), and utilities (2.8%) also struggled this week while cyclical groups like materials (+1.0%), industrials (+2.0%), and energy (+2.0%) finished with sizable gains. Meanwhile, the growth-sensitive consumer discretionary and real estate groups lost 0.1% and 2.8%, respectively.

Macro :
- German Election Result ‘Less Market-Friendly’ Than Expected: SEB
- Magnitude 3.4 Quake Detected Near North Korea Nuclear Test Site
- Trump Is Said to Get Tax Plan That Targets 20% Corporate Rate
- Iraq to Raise Oil Capacity to 5M B/D, Committed to Output Cuts

Keep an eye on :
- AB1 GY : Air Berlin Sale May Generate as Much as EU350 Million: Bild
- AB1 GY : Lufthansa to Offer EU200M for Air Berlin: Bild Am Sonntag
- AIR FP : Airbus May Sell Aerotec Unit Or Stake to Canada’s Onex : Welt
- ADEN VX : Adecco CEO Dehaze Sees Growth Opportunities With SMEs: FuW
- AZN LN : Bernstein say it could be a takeover candidate - FT article http://on.ft.com/2xvXKs8
- BPM PL : U.S. Funds Interested in Banco BPM EU2b NPL Portfolio: Sole
- CRG IM : Carige Is Said to Aim for Full Subordinated Debt Swap: Sole
- CLN VX : Clariant Won’t Adjust Exchange Ratio, Rolker Tells SamW, Postpones Shareholder Meeting for Merger: SZ
- DTE GY : Deutsche Telekom possible privatisation could fetch EUR 10bn for broadband investment - FAZ
- FB US : Facebook Abandons Plans to Change Share Structure, Avoiding Lawsuit - WSJ
- LCL LN : Ladbrokes Coral Is Said to Hire Merger Advisers: Sunday Times
- NAS NO : Monarch Airlines receives bid approach from Norwegian Air Shuttle - independent.ie
- NETS DC : Hellman & Friedman set for $5bn Nets A/S takeover - FT - http://on.ft.com/2ylOg0y
- SAP GY : SAP Agrees to Buy Gigya for Over $350M Cash, TheMarker Reports
- SIE GY : Siemens CEO Says Relationship With Russia Is Strained: Spiegel
- UHR VX : Swatch Group Sees Significant Growth Most Places: Hayek in SamW
- TKA GY : Thyssenkrupp Forms Working Group With Employee Reps on Merger
- TLW LN : Tullow to Keep TEN Field Oil Output 50,000 BOPD Until Year-End
- UBER IPO : Uber Regroups After London Taxi Setback as Lyft Signals Interest
- UBER IPO : EU Is Said to Seek More Protection for Uber-Style Jobs: Rtrs
- VOW3 GY : VW Agrees to Help German Dealers to Boost Diesel Sales: Spiegel

Barron's : Dow 1,000,000

Dow 1,000,000
Warren Buffett predicts that the benchmark will hit that number by 2117. That’s a modest goal, but one that could be difficult to reach.

“It’s tough to make predictions, especially about the future,” Yogi Berra supposedly said, as he channeled Niels Bohr, the atomic scientist.

Not so for David Meade, a so-called Christian numerologist who has been predicting that the apocalypse will arrive on Sept. 23, which, if correct, would mean you’re probably not reading this. He based this prediction on prophesies he gleaned from the New Testament, but like any good forecaster, he revised it late last week. “The world is not ending, but the world as we know it is ending,” he said to the Washington Post. Either way, Meade evidently skipped over the admonition in Matthew’s Gospel, that “you do not know the day or the hour.”

At the other extreme, Berkshire Hathaway’s Warren Buffett offered a far happier forecast last week: The Dow Jones Industrial Average will reach 1,000,000 in a century. Yes, 1,000,000, with six zeros, a seemingly incomprehensible feat, relative to Friday’s close of 22,349.59.

Yet the Sage of Omaha actually was proving Einstein’s purported observation that “compound interest is the eighth wonder of the world.” To reach 1,000,000, the Dow would have to increase at a compound annual rate of just 3.87% for the next century. That moved longtime Barron’s Roundtable sage Mario Gabelli to quip in a tweet, “Has Buffett turned bearish?” In actuality, over the past 100 years, the Dow’s compound annual growth was 5.5%, boosting the index from 95 at the end of 1916 to 20,069 this past January.

That doesn’t take into account the effect of inflation, however. With inflation averaging 3.1%, the Dow’s real compounded annual growth rate was 2.3%, according to the R Street Institute, a free-market think tank. Inflation over that span meant that at the end of 2016, it took $2,116 to buy what $100 did in 1916, based on Bureau of Labor Statistics data. (As a frame of reference, 1916 was two years after the Federal Reserve began operations.)

Although Buffett’s prediction represents a relatively modest goal for 2117, given the magical math of compounding, the mention of such big, round numbers for the Dow echoes hubristic forecasts that tend to appear around market tops. The most notorious was the book Dow 36,000: The New Strategy for Profiting From the Coming Rise in the Stock Market, published in 1999, just before the dot-com bubble burst.

The Dow was supposed to hit that vaunted 36,000 level by 2004. Moreover, the authors asserted, equities were no riskier than riskless government securities, and therefore shouldn’t have any risk premium (that is, the required return over the risk-free interest rate), even though Treasury securities, unlike stocks, come with a money-back guarantee, at maturity, at any rate. Well, we know how that turned out. From a peak of 11,722.98 in January 2000, the Dow plunged to 7286.27 by October 2002, and wouldn’t top the previous high until October 2006.

Buffett’s mathematically modest expectation of a 3.87% compounded annual rate of return is more defensible. Assuming no expansion of the price/earnings ratio—now approximately 18 times expected earnings on the Standard & Poor’s 500 index—stocks should track the increase in corporate profits. That, in turn, should parallel the growth in the U.S. economy.

Assuming 2% inflation, the Fed’s as-yet-unattained target, that means roughly 2% real growth is needed to produce 4% nominal growth. Real growth consists of labor-force increases multiplied by gains in productivity. On the former, the fertility rate in the U.S. has slid below the replacement rate (2.1 children per woman over her lifetime), which limits the size of the labor force without immigration. As for productivity, it remains sluggish, growing at just 0.6% annually since 2011.

Economist Robert Gordon has been a prominent dissenter in projecting the prosperous past of the U.S. into the future. He foresees productivity growth of 1.3%, well below the 2% achieved from 1891 to 2007. In his much-discussed 2012 paper, he concluded that the information-technology revolution of the internet and mobile phones hasn’t brought gains similar to those of the “second industrial revolution” (electricity, the internal-combustion engine, running water and indoor plumbing, communications, entertainment, petroleum and chemicals), which generated robust 20th century economic growth.

In a 2014 follow-up, Gordon added that the U.S. economy faces four headwinds: demographics (baby boomers retiring, plus lower labor-force participation by people of working age); plateauing of educational attainment; growing income inequality; and increasing debt, which will force higher taxes or reduced transfer payments in the future.

In terms of demographics and debt, Japan offers an example. The Nikkei 225 peaked at the end of 1989 at just shy of 39,000, almost twice Friday’s close of 20,296.45. In the 1980s, many predicted that Japan would rule the global economy, just as many expect of China. On the latter score, S&P lowered its rating on China’s sovereign debt last week to single-A-plus from double-A-minus, owing to too-rapid credit growth.

Buffett suggested that it is foolish ever to bet against America. He, along with most Barron’s readers, has been lucky to live through a golden age for the U.S. economy. Perhaps the future will be like the past. Maybe it will be better, maybe it won’t.

Attainment of a 4% nominal growth rate for the U.S. economy, implied by his Dow 1,000,000 prediction, may seem like a modest goal, but we’re falling short of it currently.

Godot has finally arrived. The Federal Open Market Committee last week announced that the long-anticipated shrinkage of the central bank’s $4.5 trillion balance sheet will begin in October.

To review the mechanics of monetary policy, when the central bank purchases securities, it pays for them with money created out of thin air, which then goes into the private economy. Conversely, when the central bank sells or redeems those securities, the real cash it receives is withdrawn from the economy. So, as the Fed allows its Treasuries and agency mortgage-backed securities to mature, Uncle Sam and his niece, Fannie Mae, and nephew, Freddie Mac, will have to replace those funds in private markets. Some of the $2.2 trillion of excess reserves sloshing around the banking system will probably be taken up in the process, which will still leave a surfeit for some time.

This, however, fails to capture the reality of a world in which money crosses borders freely in search of the highest returns. The Fed isn’t the dominant player around the globe by a long shot, notes Mark Grant, chief strategist of Hilltop Securities. Citing data from Yardeni Research, Grant points out that the People’s Bank of China has the Fed beat with $5.2 trillion in assets, followed by the European Central Bank with $5.1 trillion and the Bank of Japan with $4.7 trillion. The money created by the Fed is no different than that from the Swiss National Bank, the ECB, or the BOJ, Grant observes. And that foreign money heads to American shores for higher returns than its home markets’ sub-1%, or even negative, yields.

Similarly, JPMorgan economist Nikolaos Panigirtzoglou writes, the shrinkage of the Fed’s balance sheet will be offset by the central banks of the other G4 countries. JPMorgan estimates that the Fed will shrink its balance sheet by about a third, to $3 trillion, by 2021. But that will be mitigated by estimated ECB monthly purchases of 40 billion euros ($47.8 billion) of bonds in the first half of 2018, €20 billion in the second half, and no more after that. The BOJ is also projected to buy 60 trillion yen ($535.77 billion) a year.

“The Fed’s cutback is about $300 billion a year, while the other central banks are pumping in $300 billion a month,” as Hilltop’s Grant points out. “The money will go somewhere and, given that American yields are so much higher than those in Japan or Europe, a lot of it will find its way here.”

Jesse Fogarty, who manages U.S. investment-grade corporate debt for Insight Investment, a unit of BNY Mellon Investment Management, remarks that there has been a persistently strong bid for U.S. corporate bonds from global buyers—especially since the ECB began buying European corporates.

Fed Chair Janet Yellen insists that running down the central bank’s balance sheet from its crisis levels should be as uneventful as watching paint dry. While its counterparts abroad continue to expand their assets, the impact of the Fed’s shrinkage should be limited. Yellen also says that the Fed’s main policy tool will remain the federal-funds rate, which the FOMC indicated is on course for another quarter-point hike in December, from the current 1% to 1.25% target range.

In addition, the FOMC has penciled in three more hikes for 2018, based on its so-called dot plots. Less certain is who will be making those calls next year, given that Yellen’s term as chair will be up. In addition, until the Senate confirms Randal Quarles’ nomination, there will be four other vacancies on the seven-member Board of Governors after Vice Chairman Stanley Fischer retires next month.

Perhaps the most important fact to emerge from last week’s FOMC meeting is that the panel further lowered its estimate of the long-term “neutral” federal-funds rate by a quarter-point, to 2.75%. Put together with the dampening effect from foreign central banks on the Fed’s balance-sheet reduction, that points to bond yields remaining lower for longer, which is consistent with a low-growth U.S. economy.

FT : DNA start-ups attract cash from venture funds

DNA start-ups attract cash from venture funds
Groups using genomics data to diagnose diseases on track for $3bn this year

An English stately home surrounded by a wetlands nature reserve in rural Cambridgeshire is an unlikely setting for cutting-edge advances in genomics. Yet scientists at the Wellcome Trust Genome Campus, built around 18th-century Hinxton Hall, are responsible for some of the biggest genetic discoveries of the past century — the basis for a global revolution in healthcare and medicine that has led to a new start-up industry.

It was here, in the early 1990s, that researchers helped sequence the first human genome — the entire source code of the human body. Today, their successors are racing to finish another historic task, the 100,000 Genomes Project, where DNA from that many Britons is sent here by the National Health Service, to pinpoint causes for cancers and rare genetic diseases that no one has been able to diagnose before.

The groundwork laid over two decades at labs such as those in the Genome Campus has benefited an explosion of genomics software companies worldwide — those trying to build applications and services on top of the hardware that has been mining DNA data over the past few years.

The cost of sequencing a single human genome has fallen sharply, from almost $3bn in 2001 to less than $1,000 today, due to the more advanced machines invented by companies such as Illumina, a San Diego group that is one of the most active genomics investors in the world, according to CBInsights data.

With the sequencing problem cracked and vast pools of genetic data being amassed, companies that can use algorithms to perform smart data analytics and provide diagnoses have become key targets for investment.

“It’s like the microelectronics industry: [DNA] sequencing is getting aggressively cheaper and quicker, so the new industries will be about managing the big data and the discoveries that come from it,” says John Chisholm, executive chairman of Genomics England, which is running the 100,000 Genomes Project, and is also former chairman of the UK’s Medical Research Council. “A worldwide movement is building pace here, it’s absolutely clear that once we understand the genome, it will totally revolutionise the life experience of humanity.”


In the past month, start-ups building clinically useful software and data-mining applications have received a windfall in venture funding. They offer services as varied as cancer screening and diagnosis, epidemic monitoring and fertility treatments.

In early September, Chinese genome data company Wuxi NextCode announced it had raised $240m from investors such as Silicon Valley VC firm Sequoia Capital and Alibaba founder Jack Ma. A week later, US consumer genetics company 23andMe confirmed a $250m round, also led by Sequoia, while Silicon Valley’s Color Genomics netted $80m from backers such as Laurene Powell Jobs, wife of the late Apple co-founder.

In Europe, where investors tend to be tighter-fisted, Sophia Genetics, which is based in Cambridge and specialises in developing algorithms for genomic data analysis, cashed a $30m cheque from Balderton Capital.

“In the last decade, the challenge of using genomic data for clinical diagnosis has moved from being primarily a chemical and hardware problem to becoming a data problem. And data problems are solved with software solutions,” says James Wise, a partner at Balderton in London, who led the round.

Although copious amounts of genome data have allowed companies to start analysing it, some believe that technological challenges remain. “We don’t know what cancer looks like that early,” says Helmy Eltoukhy, chief executive of Guardant Health. “It’s not a single disease, it’s 10,000 different diseases. It’s no wonder that early detection hasn’t worked to date, because we don’t know what we are looking for.”


Nevertheless as the cost of genomic sequencing falls, healthcare systems including the NHS are attempting to tailor and target their services to individuals, based on their unique genetic code — a way both to save lives and cut costs.

“In 2001, it cost the industry $3bn and 13 years of research to sequence a single human genome. Today we can do that for less than $1,000 in a couple of days,” says Paula Dowdy, senior vice-president for Europe at Illumina.

Soon the company, which also has lab space at the Genome Campus in Cambridgeshire, will be able to offer the service for a mere $100.

“It’s not just by accident that VC funding is coming to this market. The opportunity is clearly linked to that massive reduction in price. It enables completely new applications and attracts capital around that,” Ms Dowdy adds.

Venture capitalists are raring to take a bite out of this burgeoning sector: the amount of money invested in genomics is on track to hit $3.2bn in 2017, and has already surpassed the 2016 total, which was $1.7bn, according to CBInsights.

The deals are also becoming significantly chunkier — cancer detection company Grail, which recently spun out of Illumina, raised more than $900m in second-round funding in March, while another cancer diagnostics start-up Guardant Health raised $360m, led by SoftBank in May.

“We are increasingly becoming reimbursed by major insurance payers in the US, so we are planning a major commercial expansion,” says Helmy Eltoukhy, the chief executive of Guardant Health.

“Today, for £1,000 you can essentially diagnose any cancer: lung, colon, melanoma, ovarian, breast and so on. For hospitals, it’s a no-brainer,” says Jurgi Camblong, chief executive of Sophia Genetics, whose software will help diagnose more than 100,000 patients with cancers and congenital disorders in 2017, working with 350 hospitals around the world.

The more diagnoses it makes, the better Sophia’s algorithms become at spotting diseases in a patient’s genetic code. Ultimately, it should be able to diagnose cancers in the earliest stages, thus, significantly cutting advanced treatment costs.

If you know what you are looking for, gene diagnostics can be even cheaper, says Angela Silmon, chief executive of NewGene, a joint venture between Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. “American companies like Color Genomics are offering breast cancer tests to the NHS for £160, so it has brought a lot of price pressure to the area, we just can’t compete,” she says.

At the Wellcome Genome Campus, scientists are alive to the possibility of commercialising their work and are starting to spin out companies that can service hospitals and clinics.

“We are in the early stages of a revolution. In the current phase, those businesses that focus on data-crunching tools and techniques will have something immediately marketable,” Sir John says. “After that, insights from the data — the therapies that save lives — those will reap the largest rewards.”

FT : Disney and Altice spar over cost of carrying ESPN and ABC

Disney and Altice spar over cost of carrying ESPN and ABC
Dispute will sharpen focus on performance of networks in an age of cord-cutting

Walt Disney is in a stand-off with one of America’s largest cable companies over the cost of carrying its ESPN and ABC channels in a dispute that will sharpen the focus on the performance of its networks in an age of cord-cutting. 

Altice USA, the acquisitive cable group controlled by Patrice Drahi, said Disney had asked for “hundreds of millions of dollars” in new fees to carry ESPN and ABC despite audience ratings at ABC “declining in the double digits for years”.

It added that Disney, which also owns the Disney Channel, was threatening to pull its networks from Altice. The company owns cable systems including Optimum and Suddenlink and has more than 4m subscribers.

Disputes between cable companies and media groups over the cost of carrying channels are not new, but this is thought to be the first time that a carrier has publicly balked at charges sought for ESPN, the most watched sports network.

The dispute underscores the fact that ESPN is no longer immune to the negative effects of cord-cutting — the cancellation of pay-TV subscriptions in favour of cheaper online alternatives. 

For years ESPN had seemed impervious to changes in viewing trends even as rival channels have been hit by subscriber and ratings declines. But in the summer of 2015 warnings from Disney’s chief executive Bob Iger about slowing subscriber growth at the network sent the media sector into a tailspin.

Disney has responded by exploring new ways of delivering ESPN programming to consumers. It recently acquired a controlling stake in BAMTech, a video technology group, and is working on a standalone ESPN streaming service with new sports programming. 

Disney said it had “a responsibility to make our viewers aware of the potential loss of our programming” from Altice USA. Customers of Altice’s Optimum service in New York will be affected if Disney yanks its networks, meaning they will no longer be able to watch ESPN’s Monday night NFL games or ABC hits such as Modern Family.

Altice, which was recently linked with a bid for rival Charter Communications, kept most of the money its customers paid for cable television, Disney said. “The typical Optimum customer pays $160 or more each month for service to Altice, and the bulk of that money goes into their pocket.” 

Altice hit back saying “skyrocketing programming costs, particularly those charged by broadcasters and sports networks, are the greatest contributor to rising cable bills”. ESPN, it added, was “already the most expensive basic cable channel in history. This behavior by ESPN is anti-consumer.”

(Challenges) AfD: cette ancienne banquière de Goldman Sachs peut gâcher la victo

AfD: cette ancienne banquière de Goldman Sachs peut gâcher la victoire de Merkel

La poussée de l'AfD menace de gâcher la victoire d'Angela Merkel, ce dimanche 24 septembre, jour des législatives Outre Rhin. Les nationalistes ont misé sur un discours anti-musulman offensif, un programme économique ultra-libérai et anti euro, et une tête de liste, ancienne de Goldman Sachs, Alice Weidel. Le parti est troisième dans les sondages.
0 RÉACTIONSAlice Weidel, ancienne banquière de Goldman Sachs et tête de liste de l'Afd en Allemagne.
Les nationalistes sur une tête de liste, ancienne banquière de Goldman Sachs, Alice Weidel.
(C) SIPA
Drôle d'attelage qui menace de gâcher la victoire d'Angela Merkel ce 24 septembre, jour de législatives Outre Rhin. Un couple improbable de candidats, tête de liste pour l'AfD, Alternative für Deutschland, parti de la droite dure. Alice Weidel, 38 ans, et Alexander Gauland, 76 ans. Lui, un atrabilaire, ancien membre du parti d'Angela Merkel (CDU), qui, il y a deux semaines encore, a chanté les louanges de la Wehrmacht, l'armée d'Hitler. Elle, une lesbienne, professeur d'économie, qui parle le chinois et qui vit avec une compagne sri-lankaise.

Alice Weidel économiste et lesbienne assumée
Plus que le septuagénaire, avocat colérique originaire de l'ex-RDA, c'est la trentenaire qui a le profil le plus surprenant. Grande, belle, blonde, elle a commencé certains de ses meetings en annonçant " je suis homosexuelle et nous élevons deux enfants avec ma partenaire ". Puis jetant un regard circulaire sur l'audience " tiens, personne ne sort de la salle, je croyais pourtant que l'AfD était un parti intolérant ." Titulaire d'un doctorat en économie, ancienne banquière passée par Goldman Sachs et Allianz Global Investors, elle a vécu six ans en Chine. Dans son parti, où elle a connu une ascension fulgurante grâce à des discours à la serpe sur la place des musulmans en Allemagne, elle a bâti le programme économique des législatives, l'orientant très libéral et très anti-euro.

Et c’est grâce à ces prises de position ultra-dures que l’AfD a grimpé dans les sondages. Crédité ces derniers mois de 7% des intentions de vote, il a atteint la semaine dernière 12%, se hissant à la 3è place, derrière les conservateurs (36%) et les socio-démocrates (21,5%).

"Le thème des réfugiés, escamoté pendant la campagne"
" Pendant la campagne beaucoup d’Allemands ne sont senti ni entendus, ni compris, explique le psychologue Stephan Grünewald, dirigeant de l'institut d'opinion Rheingold, qui vient de mener une enquête sur le moral des électeurs. Beaucoup sont désorientés, incertains et insatisfaits. Pour eux, le thème majeur qu'est la crise des réfugiés a été escamoté par la politique. " Mais, selon l'expert, ce n'est pas leur seul sujet de frustration. "Un sentiment diffus de malaise croît dans le pays. Malgré sa réussite économique, l'Allemagne est vue comme un pays à l'abandon, avec des écoles et des autoroutes défoncées, des zones de non droit, des injustices sociales et des accords secrets entre la politique et l'industrie…".

Né il y a quatre ans à peine, l’AfD a agrégé les mécontents, les perdants de la mondialisation, les inquiets de la « culture de bienvenue » de la chancelière, et a multiplié les succès électoraux. Le plus spectaculaire: celui réalisé il y a un an, le 4 septembre 2016, lors de l'élection régionale dans le petit Land de Mecklembourg-Poméranie- Antérieure, dans l'est du pays. Non seulement il est arrivé en deuxième position, dépassant les 20% des voix pour la deuxième fois de son histoire, mais il a battu le parti conservateur (CDU) de la chancelière, dans la circonscription même où Angela Merkel est députée depuis 1990. Un séisme à l’époque pour la patronne de l'Allemagne, que la presse avait qualifié de "Debakel " (débâcle), "Desaster " (désastre) et " Merkel-Dämmerung " (crépuscule).

Mieux vaut s'abstenir que de voter AfD
« L’AfD a commencé comme un parti anti-euro, explique Alexander Graf Lambsdorff, élu libéral et vice-président du Parlement européen et candidat aux législatives. Insensiblement, il est devenu anti-réfugiés, anti-islam et anti-establishment. » Et, avant tout, anti-Merkel ! En bon populiste, il surfe sur les peurs et les frustrations, mais réussit le tour de force de mobiliser, à chaque vote, beaucoup d’abstentionnistes. De droite, comme de gauche. Ce 24 septembre, il a tellement appelé à la mobilisation de ceux qui hésitent à aller aux urnes que le ministre, et proche d’Angela Merkel, Peter Altmaier a déclaré qu’il valait mieux ne pas se déplacer que de voter AfD.

Le 4 septembre 2016, au soir de l’annonce des résultats catastrophiques -pour la chancelière- dans le Mecklembourg, le tabloïd le plus lu d’Allemagne, Bild, se demandait « Combien de claques Merkel va-telle encore supporter? » Puis deux jours plus tard le quotidien en rajoutait: « La CDU peut-elle encore gagner des élections avec Merkel? » A l’époque, l’intéressée avait répondu, laconique: « Tous les politiques doivent désormais réfléchir à ce qu’on peut faire pour regagner la confiance et, naturellement, moi la première. » Depuis, son parti a remporté la plupart des élections régionales. Ce soir, ce sera pour elle un moment de vérité.

Mais une chose est sûre: l’AfD fera une entrée fracassante au Bundestag, la diète fédérale, à laquelle un parti accède s’il dépasse les 5% de voix. D’où l’éditorial de l’hebdomadaire Spiegel la semaine dernière « Merkel, mère de l’AfD ».