FT : China offers open goal for Novo Nordisk’s weight loss drug

China offers open goal for Novo Nordisk’s weight loss drug
Danish maker of Wegovy has little competition in the country and massive demand that it can take advantage of

In China, as in many other countries, slimness is an oft-promoted beauty standard. But the actual statistics in the country, with more than half the population classified as overweight, tell a different story. This is good news for Novo Nordisk’s obesity drug Wegovy. 

Wegovy, which contains the active ingredient semaglutide, has been approved in China for long-term weight management for overweight and obese people. The Danish drugmaker has little competition and massive demand it can take advantage of.

The supply of drugs containing semaglutide has been highly controlled and limited in mainland China as, until now, they were approved only for the treatment of type 2 diabetes. Even so, the market was valued at about $1.7bn last year, according to analytics group Clarivate. A severe shortage in the country has resulted in the drugs trading at well over double their prescription price on the black market.

There are just two local drugs that have already been approved for weight loss — Huadong Medicine’s liraglutide and Benamae Pharma’s beinaglutide. There is a strong pipeline of local rivals that are in their final stages of clinical trials. But they will have a difficult time commercialising the drugs in the short term due to Novo’s patent on semaglutide that runs through 2026. Shares in Huadong, down 30 per cent in the past year, reflect investors’ pessimism on the local sector despite promising developments.

That may be too harsh — at least considering their long-term prospects. Demand for weight loss drugs is set to grow at unprecedented levels. In China, the number of adults overweight is expected to triple, with the number of people classified as obese projected to increase more than sevenfold by 2030 from 2000 levels, according to Chinese public health research.

There is even bigger potential for export. India has the third-largest number of people living with obesity, behind China and the US. Novo Nordisk’s Wegovy and Ozempic, plus Eli Lilly’s rival product, are not available in India. There are no plans in the near future to supply the country due to global shortages. Ozempic is designed for type 2 diabetes but is often used off-label for weight loss purposes. More than a tenth of the Indian population is estimated to be living with diabetes. That should give Chinese weight loss drugmakers room for growth in the longer term.

In the meantime, Novo stands to gain an exceptional windfall in one of the biggest markets in the world.

FT : Stellantis threatens to halt UK production over EV targets

Stellantis threatens to halt UK production over EV targets
Vauxhall owner could move production to other sites in Europe, as government quotas threaten returns

Vauxhall owner Stellantis has warned it could stop production in the UK unless the British government does more to stimulate demand for electric vehicles or change its current electrification policy.

In the company’s strongest threat yet against the UK’s EV quotas, Maria Grazia Davino, the carmaker’s top UK executive, warned of tough EV mandates amid slowing sales in battery-run cars. “If this market becomes hostile for us, then we will enter an evaluation of producing elsewhere,” she said. “Stellantis production in the UK could stop.”

Her comments follow that of Stellantis chief executive Carlos Tavares, who called Britain’s EV policy “terrible”, which threatened to bankrupt carmakers.

The carmaker, which owns the Vauxhall, Peugeot, Citroën and Jeep brands, said it was considering the future of the whole UK operations.

It directly employs 2,500 people in both Luton and its Ellesmere Port factory in Cheshire. In Luton, it manufactured 90,000 diesel vehicles in 2023 and produced just under 4,500 electric vans in Ellesmere Port in the 3 months to December last year. Luton will start making some larger battery vans from 2025.

Speaking at the Society of Motor Manufacturers and Traders’ annual summit in London on Tuesday, Davino said the UK’s quota regime, which requires manufacturers to meet EV sales targets and rise annually, had put the company’s UK financial return “under stress”.

Her warning is the latest among car executives pushing back on the government’s EV quotas, with EV targets of 22 per cent of overall car sales this year, rising every year until 2030 to 80 per cent.

Carmakers that miss the targets face heavy penalties, though the scheme features concessions that aim to minimise the chance of manufacturers paying fines.

EV sales are rising slower than had been expected, leading several carmakers to warn they risk missing the targets. Ford’s then European boss Martin Sander told the Financial Times last month that the carmaker would divert petrol models to other countries to avoid crippling fines amid weak EV demand.

Davino said the company needed to find the right balance within the government mandate, and that a decision on the future of its UK production would probably come in less than a year.

About 14 per cent of Stellantis’s car sales, including the Peugeot, Citroën, Fiat and Jeep brands, in the UK are electric, while almost 8 per cent of its vans are battery model.

>>> US Research Calls I

Research Calls I
  • Upgrades:
    • Ascendis Pharma (ASND) upgraded to Buy from Hold at TD Cowen; tgt raised to $175
    • Ball Corp (BALL) upgraded to Buy from Hold at Truist; tgt raised to $76
    • Capri Holdings (CPRI) upgraded to Overweight from Equal Weight at Wells Fargo; tgt lowered to $43
    • C.H. Robinson (CHRW) upgraded to Outperform from In-line at Evercore ISI; tgt raised to $99
    • Cloudflare (NET) upgraded to Neutral from Sell at UBS; tgt raised to $82
    • Compass (COMP) upgraded to Hold from Underperform at Gordon Haskett; tgt raised to $3.75
    • Comtech Telecom (CMTL) upgraded to Hold from Underperform at Jefferies; tgt $3.50
    • Credo Technology Group (CRDO) upgraded to Buy from Hold at TD Cowen; tgt raised to $35
    • Eni S.p.A. (E) upgraded to Buy from Neutral at Redburn Atlantic
    • Eversource Energy (ES) upgraded to Neutral from Underperform at BofA Securities; tgt $61
    • Gap (GPS) upgraded to Buy from Hold at TD Cowen; tgt raised to $30
    • Honest Company (HNST) upgraded to Buy from Hold at Loop Capital; tgt $3
    • Marqeta (MQ) upgraded to Overweight from Equal Weight at Wells Fargo; tgt $7
    • XPeng (XPEV) upgraded to Neutral from Sell at Citigroup; tgt raised to $8.30
  • Downgrades:
    • 10x Genomics (TXG) downgraded to Neutral from Buy at Guggenheim
    • Airbus (EADSY) downgraded to Hold from Buy at Deutsche Bank
    • Alimera Sciences (ALIM) downgraded to Neutral from Buy at H.C. Wainwright
    • ASE Technology (ASX) downgraded to Equal-Weight from Overweight at Morgan Stanley
    • Beyond Air (XAIR) downgraded to Neutral from Buy at BTIG Research
    • DoubleVerify (DV) downgraded to Equal-Weight from Overweight at Morgan Stanley; tgt lowered to $21
    • Hub Group (HUBG) downgraded to In-line from Outperform at Evercore ISI; tgt $44
    • Old Dominion (ODFL) downgraded to In-line from Outperform at Evercore ISI; tgt lowered to $196
    • PENN Entertainment (PENN) downgraded to Mkt Perform from Outperform at Raymond James
    • ResMed (RMD) downgraded to Perform from Outperform at Oppenheimer
    • Sea Limited (SE) downgraded to Neutral from Overweight at JP Morgan; tgt lowered to $78
  • Others:
    • Blackstone Mortgage Trust (BXMT) initiated with a Peer Perform at Wolfe Research
    • Celsius (CELH) initiated with a Hold at Truist; tgt $60
    • Clearside Biomedical (CLSD) initiated with an Outperform at Oppenheimer; tgt $5
    • Comcast (CMCSA) initiated with a Buy at Goldman; tgt $44
    • Diversified Energy Company plc (DEC) initiated with a Buy at Truist; tgt $18
    • eBay (EBAY) resumed with a Neutral at JP Morgan; tgt raised to $60
    • Fox Corporation (FOXA) initiated with a Buy at Goldman; tgt $42
    • FTAI Aviation Ltd. (FTAI) initiated with a Buy at Jefferies; tgt $120
    • Gossamer Bio (GOSS) initiated with an Outperform at Oppenheimer; tgt $9
    • Inter & Co (INTR) resumed with a Buy at Citigroup; tgt $6.80
    • Keros Therapeutics (KROS) initiated with an Outperform at Oppenheimer; tgt $102
    • Ladder Capital (LADR) initiated with an Outperform at Wolfe Research; tgt $13
    • Liquidia Technologies (LQDA) initiated with a Perform at Oppenheimer
    • MoonLake Immunotherapeutics (MLTX) initiated with an Outperform at Oppenheimer; tgt $104
    • Paramount Global (PARA) initiated with a Sell at Goldman; tgt $9.50
    • Rivian Automotive (RIVN) initiated with a Buy at Guggenheim; tgt $18
    • SM Energy (SM) initiated with a Hold at Truist; tgt $51
    • Stagwell (STGW) initiated with a Neutral at Goldman; tgt $6.50
    • Starwood Property Trust (STWD) initiated with a Peer Perform at Wolfe Research
    • Viking Holdings Ltd (VIK) initiated with a Buy at HSBC Securities; tgt $36
    • Walt Disney (DIS) initiated with a Buy at Goldman; tgt $125
    • Warner Bros. Discovery (WBD) initiated with a Neutral at Goldman; tgt $8.50
    • Zeta Global (ZETA) initiated with an Outperform at RBC Capital Mkts; tgt $20

>>> US Gapping down

Gapping down
In reaction to earnings/guidance
:
  • POOL -11.6%, EPAC -8.4%
Other news:
  • SEDG -17.4% (files for $300 mln convertible notes offering; reaffirms Q2 revs guidance)
  • OMI -4.1% (CFO resigns at request of the company)
  • BIRK -4% (files for 14 mln ordinary share offering by selling shareholder)
  • LESL -3.9% (in sympathy with weak POOL guidance)
  • ORN -3.1% (announces three contract awards total value $63 mln)
  • SWIM -1.7% (in sympathy with weak POOL guidance)

>>> US Gapping up

Gapping up
In reaction to earnings/guidance
:
  • HIVE +3.4%
Other news:
  • GGR +9.2% (Castrol to invest up to $50 mln in Gogoro)
  • CORZ +8.6% (announces new contract with CoreWeave for delivery of approximately 70 MW of additional infrastructure to host high-performance computing operations)
  • ARVN +7.8% (names new CFO)
  • HOWL +7.3% (Highlights Initial Safety and Efficacy Data from its Ongoing Phase 1 Clinical Trial Evaluating WTX-330 in Patients with Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphoma)
  • IMMP +5.3% (announces a License Agreement with Cardiff University granting the Company exclusive rights to develop and commercialise anti-LAG-3 small molecules)
  • BTAI +5% (Announces Positive Topline Results from Post-Marketing Requirement Study Evaluating PRN Treatment of IGALMI (dexmedetomidine) Sublingual Film for Agitation Associated with Bipolar Disorders or Schizophrenia) FAAS +4.7% (secures allocation of an initial tranche of 5,120 NVIDIA H200 GPUs)
  • CORT +4.6% (announces results from CATALYST study)
  • MMLP +4.2% (issues statement on statement on crude oil pipeline spill),
  • VIAV +2.9% (Provides Benchmarking and Validation at Spring 2024 O-RAN PlugFest as U.S. NTIA Calls for O-RU Commercialization)
  • ADV +2.8% (CEO bought 40000 shares)
  • IDYA +2.7% (Announces First-Patient-In for Phase 1 Clinical Trial Evaluating IDE397 and Trodelvy Combination in MTAP-Deletion Bladder Cancer)
  • LOT +2.1% (secures investment from strategic investor)
  • IONS +1.8% (announces olezarsen FCS New Drug Application accepted for Priority Review and enrollment in Phase 3 sHTG program completed)
  • PLUG +1.6% (achieved a significant milestone reaching 7.5 gigawatts in global Basic Engineering and Design Package contracts since introducing the offer two years ago)
  • DAR +1.1% ( approved the extension for an additional two years of its previously announced share repurchase program and refreshed the amount of the program back up to an aggregate amount of $500.0 million)

>>> US Early premarket gappers

Early premarket gappers
  • Gapping up:
    • GGR +9.2%, ARVN +7.8%, IMMP +5.3%, FAAS +4.7%, CORT +4.6%, HIVE +4.4%, ADV +4.2%, MFC +1.9%, URGN +1.2%, DAR +0.9%
  • Gapping down:
    • SEDG -14.7%, POOL -10.4%, EPAC -9.2%, SWIM -5.6%, LOT -4.9%, LESL -4.1%, BIRK -3.8%, ORN -3.1%, HALO -3%, MMLP -2.1%, OMI -1.4%, BA -0.8%, TRGP -0.7%, TREX -0.6%

>>> Europe : Brokers Upgrades & Downgrades - 25th of June 2024 V2(+)

>>> Up
* Admiral Raised to Buy at Berenberg
* Argenx ADRs PT Raised to $512 from $463 at Citi
* Eli Lilly PT Raised to $1,000 from $892 at Truist Secs
* Eni Raised to Buy at Redburn; PT 17.30 euros
* Nexans PT Raised to 132 euros from 125 euros at Jefferies
* Segro PT Raised to 1,149 pence from 1,069 pence at Citi
* Wacker Chemie Raised to Buy at Baader Helvea; PT 122 euros

>>> Down
* Airbus Cut to Hold at Deutsche Bank; PT 155 euros (+)
* Direct Line Cut to Hold at Berenberg
* IAG Cut to Hold at Goodbody (+)
* INPST NA Cut to Neutral-Short Term Sell at Santander Biuro Maklerskie
* Ocado PT Cut to 215 pence from 345 pence at Morgan Stanley
* Telia Cut to Hold at Pareto Securities; PT 30 kronor (+)

>>> Initiation
* Comcast Reinstated Buy at Goldman; PT $44
* Disney Reinstated Buy at Goldman; PT $125
* Fagerhult Group AB Rated New Buy at SEB Equities(Earlier)
* MaaT Pharma Rated New Buy at Stifel; PT 16 euros
* Me Group Rated New Buy at Peel Hunt; PT 350 pence
* Nanobiotix SA Rated New Buy at Stifel; PT 16 euros
* NRC Rated New Buy at Pareto Securities; PT 16 kroner (+)
* Raspberry Pi Rated New Buy at HSBC; PT 440 pence

>>> Call
* Admiral Raised to Buy at Berenberg, Direct Line Cut to Hold (+)
* Positioning Still Reflects US Stocks Preference: Citi’s Montagu (+)
* Segro’s Structural Growth Drives New Street-High PT at Citi