FT : Carlyle-backed life sciences investor launches $1.5bn clinical trials fund

Carlyle-backed life sciences investor launches $1.5bn clinical trials fund
Abingworth wants to pursue royalty-based partnerships with major pharma groups

Carlyle-backed investor Abingworth is tapping investors for a fund worth up to $1.5bn to bankroll clinical trials, as it pioneers partnerships with big pharmaceutical companies for a share of royalties from new drugs.

The UK-based life sciences investor is planning to finance as many as eight late-stage trials with the new fund, according to people familiar with the fundraising. Carlyle, the private equity group which bought Abingworth in 2022, will also invest in the fund as a limited partner, the people said. 

The fundraising effort comes after Abingworth signed two royalty deals with large pharmaceutical and biotech companies earlier this year, and as the fund plans to return around $500mn to investors in a year in which the biotech venture capital sector has struggled.

In February, it announced a collaboration with California’s Gilead Sciences to develop the cancer drug Trodelvy in a deal worth up to $210mn. Trodelvy is already approved to treat some cancers including breast cancer, and Abingworth is now helping to fund trials to see if it can tackle lung cancer. 

In April, Abingworth agreed to fund clinical research for an asthma inhaler with Israeli drugmaker Teva in a deal worth up to $150mn. 

The latest fund is likely to close by the first half of next year, the people said.

Founded in 1973, Abingworth previously focused on venture capital investments in early stage biotech companies.

It hopes the new fund will attract larger pharmaceutical companies that want to reduce their capital expenditure, while still pursuing a larger portfolio of potential drugs for “more shots on goal”, an industry term for maximising the chances of getting a successful drug.

Pharma groups are eager to refill their drug pipelines as many blockbuster medicines will go off patent in the coming years. While smaller biotechs have previously done deals with specialist royalty companies to secure financing for expensive trials, it is unusual for larger drugmakers to take this approach. 

Last year, Abingworth raised a $356mn fund to invest in trials alongside companies, which it said at the time was “significantly oversubscribed”, exceeding its target of $300mn.

Abingworth has told potential investors in the fund that it has historically had a higher-than-average success rate in spotting the right medicines and developing them in phase-three trials, with about 80 per cent of experimental medicines that it had helped finance receiving approvals. This compares to an industry average of about 55-60 per cent, the people said.  

Abingworth previously invested in so-called “co-development deals” through portfolio company SFJ Pharmaceuticals. But in August, it hired SFJ Pharmaceuticals’ chief executive Robert deBenedetto to work with pharma companies and larger biotech companies. 

The majority of these deals will now be done in-house or with Abingworth’s wholly owned platform Launch Therapeutics.

Abingworth and Carlyle declined to comment.

FT : Pharma deals fall to lowest level in almost a decade

Pharma deals fall to lowest level in almost a decade
Experts forecast Trump administration could usher in new era of mergers and acquisitions among drugmakers

Deals in the pharmaceutical industry have sunk to their lowest level in almost a decade, as the world’s biggest drugmakers shy away from big bets on commercially ready medicines in favour of earlier-stage drug developers.

By late November, pharma groups such as Eli Lilly, Novartis and Vertex Pharmaceuticals had completed a total of 558 deals globally, worth a combined value of $67.2bn, the lowest level for that stage of the year since 2016, according to London Stock Exchange data.

The biggest biotech deal of the year — Vertex’s $4.9bn buyout of autoimmune disease biotech Alpine Immune Sciences — pales in comparison to last year’s biggest acquisition: Pfizer’s $43bn takeover of cancer drug developer Seagen. The dollar value of deals by late November stood at half that of last year, according to LSEG data.

The dearth of blockbuster deals this year — driven by pharma groups concentrating on digesting larger deals from last year as well as the frothy valuations of the larger listed biotechs turning off potential acquirers — is the main factor behind the slow mergers and acquisitions activity this year, advisers told the Financial Times.

This is despite an expected $59bn loss in sales across the major pharma groups when 190 drugs lose exclusivity by the end of the decade, according to KPMG.

Andrew Weisenfeld, an investment banker at MTS Health Partners, which advised Seagen, said: “To some degree, [pharma groups] addressed their loss of patent life on existing drugs so they got pickier — and a lot of bigger companies got really expensive, and people just aren’t paying those prices.”

“Big pharma ate through a lot of the available targets in 2023,” said Jamie Leigh, co-chair of Cooley’s mergers and acquisitions group. “[Companies were] more judicious about the remaining pool in 2024.”

Some bigger deals have been completed this year but none were instances in which a pharma group was buying a biotech to get hold of promising drugs. Novo Nordisk this year agreed to pay $11bn to acquire three manufacturing sites from Catalent in a three-way deal involving its parent company, while Sanofi handed control of its consumer drug division to private equity group Clayton Dubilier & Rice in a €16bn deal.

A tough antitrust environment under Lina Khan’s Federal Trade Commission as well as the political uncertainty of an election year has also slowed deal activity. But the election of Donald Trump could usher in the return of bigger healthcare tie-ups.

“Trump coming to power is generating cautious optimism for increased deal flow and investments in the biopharma sector” said Zahid Moneer, a senior managing director of healthcare at BNP Paribas. ‘There’s a cautious buzz around that in January you will see a significant rebound in activity.”

For the time being, pharma companies have prioritised bolt-on deals of below $5bn, favouring private companies over listed groups. Danish pharma group Lundbeck bought neuroscience start-up Longboard for up to $2.6bn in October, while Merck bought privately owned ophthalmology biotech EyeBio for up to $3bn.

Siddhart Nahata, global head of healthcare investment banking at Morgan Stanley, said: “Bolt-ons are business as usual — large-cap [pharma groups] have had to keep doing bolt-ons to supplement their internal R&D efforts. There’s no way around that.”

Despite some of the uncertainty still affecting the biotech sector, in particular what Trump’s pick for health and human services secretary Robert F Kennedy Jr might mean for drugmakers and vaccine makers, most dealmakers expect a more positive outlook next year.

“Healthcare has had a lot of dramatic headline news in the past 10 days,” Nahata said. “We need to digest what that actually means in terms of policy, and that will have implication in terms of what people pursue in terms of M&A . . . but I do certainly expect 2025 to be a more active year.”

FT : Trump picks Lebanese billionaire Massad Boulos as Middle East adviser

Trump picks Lebanese billionaire Massad Boulos as Middle East adviser
President-elect thrusts father-in-law of daughter Tiffany into peace talks between Israel and Hizbollah

President-elect Donald Trump has tapped his daughter’s father-in-law Massad Boulos as a senior adviser on the Middle East, thrusting the Lebanese auto tycoon into the fragile effort to uphold a US-brokered ceasefire between Israel and Hizbollah in Lebanon.

Trump said Boulos would be senior adviser to the president on Arab and Middle Eastern affairs, joining real estate developer Steve Witkoff, who he named special envoy to the region, and his nominee for US ambassador to Israel Mike Huckabee.

None have traditional diplomatic backgrounds and reflect Trump’s penchant for elevating close friends and family to key positions.

“Massad is a dealmaker, and an unwavering supporter of PEACE in the Middle East. He will be a strong advocate for the United States, and its interests, and I am pleased to have him on our team!” Trump said in a post on Truth Social.

Boulos, whose son Michael is married to Trump’s youngest daughter Tiffany, spent most of the past year drumming up support for Trump among Arab Americans in the battleground state of Michigan.

Boulos recently travelled to Washington to meet senior Lebanese officials and other diplomats and US representatives. It was widely assumed he would be the next person to oversee relations between Israel and Lebanon, taking up the file from President Joe Biden’s senior adviser Amos Hochstein. 

Born into a Christian family in Kfar Akka, Lebanon, he moved to Texas as a teenager to attend the University of Houston. After graduation, Boulos joined his family’s automotive business in Nigeria, rising to lead Scoa Motors and Boulos Enterprises, which dominate the Nigerian market for motorcycles and vehicles. 

He is known to have close ties across Lebanon’s Christian political class, including with Suleiman Frangieh, a leading Christian politician and Hizbollah’s preferred candidate to fill the vacant presidency.

The US last week announced that Israel and Lebanon had agreed to a ceasefire, ending more than a year of fighting between Israel and Hizbollah.

The US-brokered ceasefire deal outlines a gradual withdrawal of Israeli and Hizbollah forces from southern Lebanon over the course of 60 days. The Lebanese army and Unifil troops are set to deploy widely in the region, which will be enforced by a US-led monitoring mechanism. 

Miss Tweed : Richemont to revamp executive committee, open to sell unperforming

Richemont to revamp executive committee, open to sell unperforming brands

Richemont on Friday announced new bosses for luxury watch brands Vacheron Constantin and Jaeger-LeCoultre but more change is afoot. Not only are heads going to roll at the Swiss group’s executive committee. CEO Nicolas Bos is quietly preparing to offload badly performing brands, industry sources and fund managers said.

“Bos has told us that he’s now ready to sell,” the manager of one hedge fund told Miss Tweed on condition of anonymity. Bos told investors a few weeks ago that it was too early to give details. They thought he had in mind some of Richemont’s watch brands, such as Roger Dubuis and Baume & Mercier, which have been struggling to grow for more than a decade now.

“It would send a very positive signal to the market if Richemont was to sell badly performing watch brands, particularly after having secured the sale of YNAP (Yoox-Net-A-Porter),” the hedge fund manager said. In October, Richemont announced a deal to sell the online fashion retailer to its rival Mytheresa, getting rid of a lossmaking business that has been a thorn in its side for years.

Fashion has never been Richemont’s strong suit, but its biggest brand Chloé is doing relatively well, industry sources say. Its ready-to-wear and wholesale revenues are understood to be up. However, bag sales are down in Asia, they said.

As always, Richemont did not reply to an email asking for comment. Like LVMH, the Swiss luxury group is going through an unprecedented generational change at a time when the fashion and luxury industry is battling its worst downturn in decades.

BRINKGREVE OUT
Richemont’s Chairman and controlling shareholder Johann Rupert told Miss Tweed at its annual general shareholders’ (AGM) meeting in September that the group was no longer planning to create a beauty division, backtracking on earlier ambitions to build a bigger presence in that field.

“I think I was wrong in calling it a division – it’s more of a coordinating role,” he said at the AGM about the group’s plans announced a year earlier to create a stand-alone beauty business called Laboratoire de Haute Parfumerie et Beauté. In light of the change of plan, Boet Brinkgreve, who was CEO of that unit and a member of Richemont’s executive committee, is no longer needed. The Dutchman, who had joined from the fragrance and dietary supplements provider DSM Firmenich in Sept. 2023, was ousted several weeks ago, industry sources said. He had been personally hired by Rupert but not fired by him, the sources say.

At LVMH, the same thing happens. You may be hired by the big boss and meet the head of HR, but the day the group decides it’s time for you to go, you don’t get to see either of them for “a thank you and goodbye” or an explanation. Instead, you’re promptly escorted to the door. It’s amazing that this has become routine at groups that claim to be well-wishing and looking after their staff. It’s also bad publicity for future recruits. Richemont and LVMH may ban employees from talking to outsiders, including journalists, but people need to share their pain with others. It’s only human.

Brinkgreve is not the only member of Richemont’s executive committee to be pushed out. Patricia Gandji, the group’s Chief People Officer and CEO of Regions, is next on the list, several industry sources said. Gandji is said to have badly handled exits such as Brinkgreve’s and that of key executives at Cartier such as Mercedes Abramo,who was deputy chief commercial officer at the French jewelry brand.

Abramo was promised a new job at Cartier but after Cartier’s new CEO Louis Ferla was appointed earlier this year, she lost support internally and had no choice but to leave. “Abramo was highly regarded,” one senior industry source noted. “Her departure came as a shock to many people internally.”

Several sources said Abramo was protected by Cyrille Vigneron, Cartier’s former CEO. Since he is no longer in charge, Abramo became vulnerable and out she went. Now it’s the turn of the group’s HR boss Gandji to face the same pressure, as she was also under the now-replaced Vigneron’s protection.

Gandji is said to have hidden several cases of moral harassment at the group and paid one person involved a significant amount of money to keep quiet about it. Alerted by CFO Burkhart Grund, Rupert found out and was furious, sources close to the group said. In the past few weeks, Gandji has already lost several members of her team, including her deputy Thomas Mirman. Mirman did not reply to a request for comment.

MUSICAL CHAIRS
In May this year, Rupert appointed as CEO Nicolas Bos, a 53-year-old Frenchman who had successfully developed Van Cleef & Arpels (VCA) for many years and spent more than three decades at the group. Rupert also named new bosses for Richemont’s two biggest brands Cartier and VCA, respectively the aforementioned Ferla, ex-CEO of Vacheron Constantin, and Catherine Rénier, who was CEO of Jaeger-LeCoultre. These appointments meant new bosses for these two brands had to be found.

Jérôme Lambert, the group’s former CEO demoted to Chief Operating Officer after Bos’s appointment in May, will be given the executive reins of the luxury watch brand Jaeger-LeCoultre (JLC), Richemont announced this week. This is not exactly a promotion.

Lambert led JLC once before, between 2002 and 2013, and then moved on to Montblanc as CEO. Few people accept going back to doing a job they did 20 years ago; they find it debasing. But not Lambert. The 55-year-old technocratic manager is widely regarded as a “yes man” who does exactly what he is told, people who work with him say. The French-Swiss Richemont veteran has bought himself a nice big house in Cologny, the chic neighborhood just outside downtown Geneva,and is happy to stay on as long as he’s well paid, people who work with him say.

Good luck to Lambert in earning the respect of his troops. It’s clear Richemont needs a new head of human resources and someone who has a better grasp of basic psychology than Gandji. People need to admire their boss. They will not work hard if they are not inspired. That’s particularly the case for people under 35.

To put Lambert in charge of a watch brand like JLC, which needs fresh energy, creativity and a strong new marketing story, looks like a bad move. Lambert is a financier, not an audacious or creative mind. Richemont may feel indebted to Lambert for his loyalty but it could have given him another job. That being said, Richemont staff say Lambert left a good impression when he was CEO of JLC.

JLC is a lovely brand with a rich heritage. It’s best known for its Reverso model with a rotating dial, which is mainly popular in the United States and in Europe. The Reverso has never been big in Asia, where sister brands such as Vacheron Constantin grew tremendously in the past decade but are now suffering from the collapse of demand for luxury watches in China.

As Miss Tweed predicted nearly a year ago, Laurent Perves, then Vacheron Constantin’s chief commercial officer, was named its CEO this week. This is good news as Perves is respected and admired internally.

For most people, the person they work for and report to is more important than the brand itself. Sometimes luxury managers look like pawns in a giant chess game. The shareholders of luxury groups see them as being interchangeable. One day they are at LVMH, the next at rival Richemont or at Kering. They try their luck elsewhere and realize it’s the same toxic, technocratic environment everywhere with little access to the big bosses or shareholders. No luxury brand can be successful without good leadership, without a strong chief they look up to and respect.

Richemont Chairman Johann Rupert is feared internally and respected for his insights into the state of the world and dangers going forward. The 74-year-old South African billionaire was the first luxury leader to predict last year that business would be tough in China and he was right. Rupert has also been preparing his succession. He has anointed the person who will be chairman in his place when the moment comes for him to leave. However, that person’s identity has been kept secret for now. Rupert has also made his family, including his son and two daughters, full shareholders of Richemont through a complex web of different structures. Officially, he and his son Anton are the only shareholders of Financière Rupert, which owns 10 percent of Richemont equity and 51 percent of voting rights. However, above it are other structures in which a wider spread of family members are shareholders.

This confusing scheme was put in place to make a takeover more difficult. Shareholders should be entitled to get more details on this complex structure in the spirit of transparency and best practice in terms of disclosure.

Barron's : The AI Race Is Entering a New Stage. Nvidia Won’t Be the Only Winner

The AI Race Is Entering a New Stage. Nvidia Won’t Be the Only Winner This Time.

The artificial-intelligence boom unleashed by the launch of ChatGPT has been governed by a single rule—bigger AI models are better. That consensus has pushed Microsoft, Google, Amazon.com, Meta Platforms and others into a spending war to source chips from Nvidia and others.

The competition could be about to change as the industry faces obstacles in its quest to build ever-larger AI models.

Nvidia has been the chief beneficiary of the spending race, since its graphics-processing units—or GPUs—are especially good at carrying out multiple calculations at the same time, significantly reducing the time required to train a model.

The most widely used metric for gauging the capabilities of AI is the number of parameters—a measure of the size and complexity of the model. The general rule is that the more parameters an AI model has, the more GPUs are required to train it efficiently.

But, for the first time, the scaling law is now facing questions. “There is minimal improvement or return beyond one trillion parameters,” according to Waseem Alshikh, co-founder and chief technology officer at Writer, a start-up which develops its own AI models.

Microsoft CEO Satya Nadella sounded defensive about the topic as he kicked off the company’s Ignite conference a few weeks ago. “It’s actually good to have some skepticism, some debate, because that, I think, will motivate, quite frankly, more innovation.”

If AI improvement breaks down, AI’s current leaders, from Microsoft, Google, and Amazon to OpenAI and Nvidia, could face a fresh set of worries about their big spending. It’s no surprise, then, that prominent AI figures are pushing back on the scaling doubts.

“[T]here is no wall,” OpenAI CEO Sam Altman recently posted on X. Dario Amodei, CEO of Anthropic, an Amazon and Google-backed AI start-up, said in a podcast that he believes “there’s no ceiling below the level of humans.”

What’s going on then? One explanation is that AI training techniques are hitting certain limits. The most likely reason is a lack of good data to train models with, according to Thomas Wolf, co-founder and chief science officer at Hugging Face, a marketplace for AI models.

“We’ve already exhausted the internet as a source of training data a few months ago,” Wolf told Barron’s. “There’s only so much high-quality text, code, and images out there.”

For Wolf, that points to a future of smaller models, which could be trained on a company or a person’s own data and run on individual devices. While AI is currently dominated by large models hosted in the cloud by a small set of major companies, the sector could eventually splinter into lots of specialized models and applications.

That could require new techniques. Meta’s Chief AI Officer Yann LeCun has publicly dismissed the idea that simply using more chips to power larger language models will lead to truly intelligent AI, known as artificial general intelligence, or AGI. LeCun has argued that developers will need to focus on developing models with memory, planning, and reasoning capabilities.

“What we’ve learned in this era of generative AI is that not only is scale important to model innovation, but so are advancements in areas like grounding and reasoning,” Microsoft’s Eric Boyd, corporate vice president of the Azure AI Platform, told Barron’s.

At some point, AI’s emphasis will shift from training to inference, the process of generating answers or results from the models. Many in the industry now believe that dedicating more computing power to inference can provide similar benefits to training.

“We are seeing the emergence of a new scaling law…with inference-time compute,” Nadella said at Microsoft’s Ignite conference.

The inference focus has big implications for Nvidia. While training is uniquely suited to the company’s GPUs, inference might be more readily handled by AI processors from Nvidia peers like Advanced Micro Devices and Intel, by custom chips from Amazon, or by a range of chip start-ups.

Nvidia is hardly unaware of the threat. It emphasized in its recent earnings report that inference makes up around 40% of its data-center revenue and is growing fast. It says that its NVL72 server system delivers a fourfold improvement in AI model training but up to a 30 times improvement in inference compared with previous systems. The new NVL72 stitches together 36 GB200 Superchips, with each GB200 connecting two Blackwell GPUs to an Nvidia Grace CPU.

In the short-term, the development of a new type of scaling related to inference is probably good news for Nvidia. In the longer term, though, a scaling shift from training to inference opens AI opportunities for Nvidia’s rivals to try to chip away at the company’s dominant role.

Thus far, the generative AI race has been met with a rush to stock up on chips to enable the training of ever-larger models. As the race moves to actually using the models, investors need to be ready for a new set of winners—even if they’re not yet entirely clear.

Barron's : U.S. Farmers Are Struggling. They Will Lose More in a Trade War, This

U.S. Farmers Are Struggling. They Will Lose More in a Trade War, This Ag Expert Says.

American agricultural abundance has fed the world for decades, but in the past few years, that has faltered. Agricultural economist Dan Basse fears that the decline of globalization and an economic and political rift between the U.S. and China puts U.S. farmers on the losing end of these changes.

“The split between the G-7 countries and the BRICs likely will culminate in differing trade patterns that work against the U.S. farmer,” Basse says, referring to the acronym for Brazil, Russia, India, and China. “There is more ag policy (and geopolitical) uncertainty today than since the early 1970s,” he says.

Basse, founder of the agricultural risk-management and advisory firm AgResource, grew up on a Wisconsin dairy and grain farm and started in the agriculture commodities business in 1979. He spoke recently to Barron’s about the impact of geopolitics on U.S. farmers, food inflation, and where he sees the future of agriculture. An edited version of the conversation follows.

Barron’s: How have agricultural trade trends changed over the years?
Dan Basse: When I first got into this business in 1979, the U.S. satisfied 62% of agricultural trade. Now we’re down to about 11%. Demand is still rising globally as the population expands, but we’ve seen this behemoth named Brazil come on to the scene. Brazil is now the world’s largest soybean and corn exporter—crowns we thought the American farmer would hold for many, many years.

Ag trade has really suffered in the past few years. The American agricultural trade deficit is at $42 billion, a record. China was traditionally our top ag importer for years, but this year it is Mexico, then Canada. China ends in third place.

How did the Trump tariffs affect trade with China?
During the trade war in 2018, the Trump administration put tariffs on China. In 2019, we signed an agreement that was supposed to be for two years, that China would import between $40 billion to $50 billion of ag goods a year. The Biden administration kept those tariffs but, for whatever reason, didn’t hold China to the agreement.

In 2023, China bought about $35 billion in ag goods, but that’s down to about $22 billion so far this year. In the past 12 months, the Chinese decided that maybe relying on the U.S. as a primary ag exporter isn’t good, so they have been buying wheat from Russia, a little corn from Argentina, and corn and soybeans from Brazil.

What should the incoming Trump administration focus on in agriculture?

Agricultural export opportunities should be front and center in terms of supporting farm income. It’s what gets futures markets excited.

I worry that, as we have moved from being a global world, we’re in what I call a duopoly of economic and political power now developing between Washington and Beijing. Ultimately, if the rhetoric doesn’t change against China, China will find its food from others, and it is leaving the American farmer out. If we lose them, there really is no replacement. It isn’t that you can’t develop India or Africa into a China at some point, but it’s years and years away.

During the campaign, Trump advocated for 60% tariffs on Chinese goods. What might be different this time if the administration tries to negotiate a deal to buy farm products?
I don’t think China was prepared for the first trade war. In this trade war, if Trump initiates one, I believe they will be much more prepared. They have sizable reserve food stocks. They have been principally buying most of their corn and soybeans from Brazil. I’m not sure the fight will be as easy as it was back in 2018 and ’19. The Chinese will be much more difficult to deal with.

The Chinese see themselves as decoupling from the U.S. and moving more toward those countries involved in the Belt and Road initiative [China’s global infrastructure development strategy], which for agriculture would be Russia, and principally Brazil and Argentina.

Maybe President-elect Trump can get a deal, but it is going to take considerable time, and U.S. farmers need to be patient for the fights that are ahead. In 2018 and ’19, the administration, through the USDA’s Commodity Credit Corp., handed out so-called Trump Bucks of about $28 billion to farmers. [CCC is an agency that can borrow money from the U.S. Treasury. At the time, it gave agricultural assistance to pay certain farmers who lost money during the trade fight with China, and also bought surplus commodities.]

I suspect that, as in 2018 and ’19, CCC payments may be how farmers stay patient as we somehow rebuild ag export markets. I know tariffs are the hammer and everybody else is a nail, but we’ll really prove whether this concept is a little more effective this time around.

Year to date, corn prices are down 15% and soybean values are 20% lower and sitting near four-year lows. What is weighing on prices, besides weak export demand?
It was a big harvest, so with more supply, prices headed lower. Even though it was the hottest summer on record overall, in the central U.S. temperatures were moderate and moisture was sufficient enough. That means we are going to have record yields this year. If we can’t send our crops to an end user, it takes a lot longer to chew through our supply. Crop prices will have a longer-term bearish tail until we can find a new demand driver.

Net farm income is down 31% since 2022, the largest two-year drop on record. In addition to low crop prices, what else is causing farmer revenue to fall?

As farmers start to plan for 2025 cropping decisions, variable costs will be higher than they were this year. That is largely due to fertilizer and seed costs, the two biggest components.

Where are production costs relative to futures prices? Will farmers lose money this year?

The national average production cost for corn is $4.69 a bushel, and for soybeans, $10.97 a bushel. CBOT [Chicago Board of Trade] corn futures are around $4.25 and soybean futures are around $9.80. Farmers will have an income, per se, but will lose money relative to their input costs. If you own your own farmland and aren’t paying land rent, that’s one thing. Farmers who rent land, which is about 30% of the U.S. farm population, will struggle and won’t have income this year. It will be a sparse year, but such is the cycle of agriculture.

You experienced the 1980 farm crisis. Is a repeat a worry?

I don’t think so. In the 1980s, farmers were overleveraged. That caused distressed farmland sales, and we saw a big drop in the land market. Data from the different land-grant universities suggest that 70% of farmland is paid for, so the farmer has used the financial bounty of recent years to pay down debt. We are expecting this downturn to be more of an operational or revenue hit.

As farmers make their 2025 planting decisions, where might they cut back, and how will that impact companies in the ag industry?

They will look at their cost structure around seed, fertilizer, or equipment. My guess is they’ll cut back on fertilizer first, since some of that builds up in the soil. The only thing corn farmers can’t do without every year in a big way is nitrogen, but they can cut back on phosphates and potassium. Farmers may say they won’t fertilize as heavily this year. You can get away with not fertilizing for one year.

During the boom times, everyone had their hands in the back pocket of the farmer, and they have been slow to pull their hands out. But suppliers are going to have to budge. Already you’re seeing pressure on the equipment dealers. Farmers can say to their Deere or Case [sales reps], I have been changing equipment every three years, I’m going to lengthen that to five years, or I’ll stop lease payments. If the farmer gets his way, he’ll then go to the seed dealers and say, I know you spend a lot on technology, but you have to help me out here. There could be some adjustment with landlords on land rents.

It’s not all gloom and doom for U.S. agriculture. Cattle producers are reaping record beef prices.

Retail beef prices last month were around $8.50 a pound, a record, supported by a very strong economy and consumer demand. We have also had the smallest U.S. beef-cow herd since 1961. That small beef-cow herd will take time to replenish, as we are only in early days for the expansionary phase.


The U.S. dairy industry, interestingly, is helping to supply more beef cattle. Dairy farmers are able to take 10% of their herd and breed a Holstein cow, or another type, with a Black Angus bull to create a crossbreed calf where the marbling is good, the ability to convert grain into beef has been good, and the consumer likes it so far. This is the first time the dairy industry is helping the beef industry get additional supply, and it has also helped the dairy industry do well.

Are we seeing consumers switching from pricey beef to cheaper pork or chicken?

Americans consume the same amount of pork every year. We’re seeing chicken consumption rising. Poultry fatigue, where consumers tire of eating chicken, hasn’t set in. In a broad sense, the strong economy and disposable income have really helped out. One postpandemic trend we’re seeing is that Americans are still consuming more food away from home than at home. This includes things like ordering food from Grubhub, where it’s prepared away from home but delivered to home. As we consume more meals away from the home, you’re seeing protein demand hold much steadier than before, with less switching from a menu perspective.

High grocery prices have been a top concern for people, although consumer price data show food prices coming down. How much does the price the farmer receives translate to what we see on the supermarket shelves?

The most recent data from the USDA say farmers receive 14.9 cents for each food dollar. The other 85 cents goes to the middleman, packaging, transportation to market—all those things add up to what you’re seeing in terms of grocery prices. What farmers are paid, the farmgate price for products like milk or pork and poultry, for example, aren’t too different from 20 years ago.

On the beef side, prices have moved up. Americans, for whatever reason, like beef and have been willing to spend more dollars on it. Hamburger, at $8.50 a pound retail, is going to remain in short supply. We all look at fast food as being a cheap meal, and we get a Big Mac—or whatever it may be—for dinner at night.

What is the future of U.S. agriculture?

Soil health will be the next discussion American agriculture needs to have. What can we do to back away from using maybe as many chemicals as we do, and how do we take care of the fertility for generations to come? We’re making progress on soil health. It’s really the next revolution in farming, but we haven’t done a very good job studying it.

We need to know the holistic picture and how the microbes and bacteria and everything all act together. What will help us save water and carbon, and what will help us in fertility? As a farmer myself, I say we do what we do to take care of the soil. But we need science and leadership to help us understand what we’re doing. As I watch Elon Musk land spaceships, I think, we know more about what is 200 miles above our heads than what is two feet under our shoes.

Thanks, Dan.

>>> Weekend Papers Summary

FINANCIAL TIMES
-Rebel forces have launched a lightning offensive in Syria's second city, Aleppo, posing the biggest threat to Bashar al-Assad's regime in the ongoing civil conflict. The militants, led by Islamist group Hayat Tahrir al-Sham, have said they are expanding their control inside the city. The assault comes as Assad faces increasing domestic and external pressures in a country shattered by years of civil war. The original rebellion was put down with military backing from Russia, Iran, and Iranian-backed militant groups, including Hezbollah. However, Israel has increased its air strikes on Iranian-affiliated targets in Syria and launched an offensive against Hezbollah in Lebanon, weakening the groups that have supported the Assad regime.
-Europe is developing technologies that could transform the world, including robotics, nuclear fusion, and quantum computers. To avoid repeating past mistakes and build the next era of innovation, Europe needs to celebrate and support experienced founders who invest in high-risk, high-reward ideas. DeepMind, founded by Demis Hassabis and Shane Legg, started when they met at the Gatsby Computational Neuroscience Unit at University College London. Hassabis, a Nobel-winning scientist and visionary AI researcher, was also an experienced founder. Twelve years prior to DeepMind, he founded Elixir Studios, a London-based games studio that closed after seven years. Hassabis expressed heartache when the industry no longer had room for small independent developers working on innovative and original ideas, stating that this was the sole purpose of setting up Elixir and something they could never compromise on.
-Ireland's general election saw Sinn Féin emerge with a narrow lead in an exit poll, despite the main opposition party's promise of policy changes, tax cuts, and spending pledges. The party won 21.1% of first preference votes under Ireland's proportional representation system, while Fine Gael was at 21% and Fianna Fáil had 19.5%. This is a "phenomenal result" for the nationalist party, which won the most first-preference votes at the last election in 2020 but has plummeted in polls in the past year. The result was unexpected as Fine Gael, the conservative party under Prime Minister Simon Harris, had been falling in opinion polls after a series of campaign missteps and was in third place going into the election. Fianna Fáil had been seen as being ahead of Sinn Féin in first place.
-The Italian government has ruled out issuing a decree to block UniCredit's takeover bid for BPM. The government has been discussing ways to counter the move, which has frustrated Rome's banking consolidation plans. Options included an emergency decree to circumvent the passivity rule, which blocks bid targets from making decisions that might affect the takeover approach. The Rome Treasury said the report of a decree published by the Financial Times was groundless. The passivity rule prevents BPM from increasing its stake in Monte dei Paschi di Siena and amending its own €1.3B offer to buy Anima.
-Hezbollah leader Naim Qassem has publicly endorsed a commitment in his group's ceasefire with Israel to move Lebanon's armed forces into the country's south, an area considered the militant group's heartland. Qassem affirmed Hizbollah's commitment to the deal, stating it was not a new agreement but an implementation of an existing UN resolution from the end of the 2006 war. The agreement confirms the withdrawal of the Israeli army from all occupied areas and the deployment of the Lebanese army south of the Litani River. Hizbollah has repeatedly claimed victory following the ceasefire, but much of southern Lebanon remains in ruins.
-Marine Le Pen has threatened France's Prime Minister, Nicolas Maduro, with further concessions on his 2025 budget to cut the country's public deficit. Barnier has already scrapped a planned electricity tax increase, a key demand of Le Pen's Rassemblement National party. Le Pen must decide whether to wring concessions from Barnier or join leftwing lawmakers in toppling him. She aims to show she is a resolved opponent, winning concessions in favor of the French people, particularly in purchasing power.
-Nissan's 2010 mass-produced electric vehicle release has been met with resistance from consumers worldwide. The industry, which spent billions on electric vehicles and batteries, is facing an existential crisis. Europe's leading battery champion, Northvolt, filed for bankruptcy, and Vauxhall owner Stellantis announced plans to shut its Luton factory, putting 1,100 jobs at risk. Ford has also announced plans to cut 4,000 jobs in Europe to address slower demand for electric vehicles.
-Trump's proposed 25% tariffs on imports from Mexico and Canada will be the most significant impact on GM, Ford, and Chrysler, according to analysts. The global auto industry has developed complex, cross-border supply chains over the past four decades, making the three biggest carmakers vulnerable to the impact of tariffs. The threat stems from the complex, cross-border supply chains the global auto industry has developed. The most exposed global carmakers are Stellantis, which sells around 40% of its cars and trucks in the US, while GM and Ford's totals are 30% and 25%, respectively.
-Germany's pro-business liberal party, the Free Democrats (FDP), has resigned after publishing an internal "D-Day" paper discussing plans to bring down chancellor Olaf Scholz's coalition. The author and FDP secretary-general resigned, taking responsibility for a scandal that rattling the party, which is struggling with low approval ratings ahead of snap elections in February. Scholz's coalition was down earlier this month, as Europe's biggest economy grapples with factory closures and one of the worst economic slumps since the early 2000s. An internal power-point presentation leaked to German media showed that the FDP had discussed "D-Day" options to quit the coalition weeks prior to Scholz's move.

NEW YORK TIMES
- Canadian Prime Minister Justin Trudeau visited President-elect Donald Trump at Mar-a-Lago in Florida on Friday night, following a threat by Trump to impose tariffs on goods from Canada and Mexico on Day 1. The visit makes Trudeau the first head of government from the Group of 7, a key forum of global coordination consisting of the world's wealthiest democracies, to visit the president-elect. Trudeau and Trump dined together on Friday evening, along with a delegation of senior Trump allies poised for top trade and security positions in his new administration. The visit comes amid pressure to persuade Trump to back down from his tariff threat. Trudeau is under pressure to persuade Trump to back down from his tariff threat.
-President-elect Donald J. Trump has reportedly endorsed the right-wing policy blueprint Project 2025, which aimed to overhaul the federal government. During the campaign, Trump claimed he had no involvement with the plan, despite many of its developers being his allies. He even criticized the policy goals as "absolutely ridiculous." However, as he prepares to return to the White House, Trump has recruited at least a half dozen architects and supporters of the plan to oversee key issues, including the federal budget, intelligence gathering, and his promised plans for mass deportations. Vought, one of the authors of Project 2025, is returning to the White House as President-elect's pick to head the Office of Management and Budget.
-Dr. Dave Weldon, a former Republican congressman and President-elect Donald J. Trump's pick to lead the Centers for Disease Control and Prevention, has been off the political stage for over 15 years. He is now running a private medical practice in Malabar, Fla., and was hardly regarded as a leading candidate to run the federal agency, a $9 billion behemoth with a staff of over 13,000. However, his views have often aligned with those of Robert F. Kennedy Jr., Trump's choice for health and human services secretary, and Dr. Weldon's potential boss. The two have maintained a 25-year relationship, and his views have often aligned with those of Kennedy Jr., who is also a potential boss for the agency.
-Syrian rebels have breached the city of Aleppo, marking the largest advance in years, according to rebels and a war monitor. The rebels, including Hayat Tahrir al-Sham, took control of "more than half of Aleppo" within hours without resistance from Syrian government forces, according to the Syrian Observatory for Human Rights. The rebels, including Hayat Tahrir al-Sham, took control of "more than half of Aleppo" without resistance from Syrian government forces. Independent Syrian media has shared images and videos of rebels in Aleppo neighborhoods and at well-known roundabouts, celebrating the situation. This has raised concerns that Syria's long-running civil war is reigniting with an intensity not seen in years.
-The largest offensive in years by Syrian opposition fighters against government forces in the northwest has sparked fears of reigniting a frozen civil war. The new rebel push began in Aleppo Province and has advanced, capturing several new villages, according to the Syrian Observatory for Human Rights. The offensive aims to stop attacks by government forces and their Iran-backed militia allies, according to a rebel commander. The new rebel push began on Wednesday and has been characterized by a deadly and deadly nature, indicating a potential escalation of the ongoing conflict.
-Early data from Adobe Analytics indicates that consumers are being drawn to discounts on various items, with Americans taking advantage of big deals on Thanksgiving and Black Friday. Shoppers spent $7.9 billion online on Friday, an 8.2% increase compared to last year, on top of $6.1 billion spent online on Thursday, which was around 9% more than the previous year. The increases were driven by large discounts on items like toys, electronics, and apparel. Target's executives have said that consumers were choosing cheaper items like candles and vases, eschewing big-ticket purchases. A clearer picture of Black Friday sales, including in-store spending, will emerge in the days ahead.
-Taiwan's President Lai Ching-te is planning to visit the Marshall Islands, Tuvalu, and Palau, which are among the dwindling number of Pacific Island nations that maintain diplomatic ties with Taiwan. Since the 1970s, dozens of countries have shifted ties to China, with Beijing claiming Taiwan as its territory and insisting that governments end diplomatic relations with Taipei if they want full relations with China. President-elect Donald J. Trump has called for Taiwan to sharply increase its military spending and complained about Taiwan's global dominance in semiconductors. However, Trump's proposed cabinet includes Republicans who have been deeply distrustful of China and sympathetic to Taiwan. Trump will bring to U.S. dealings with Taiwan and China.
- President Emmanuel Macron of France has taken the world on a live televised tour of the newly renovated Notre-Dame Cathedral in Paris, five years after it was damaged in a devastating fire. The landmark is expected to reopen to the public next month. Macron took viewers on a tour of the cathedral's dazzlingly clean interior and rebuilt roofing, a testament to the efforts made to restore the iconic landmark. Philippe Jost, the head of the reconstruction task force, told Macron that viewers are seeing the cathedral like they have never seen before. The cathedral is expected to reopen to the public next month. The French president's visit marks a significant milestone in the restoration of the iconic landmark, marking a significant milestone in the country's history.
-A coalition of Canada's major news outlets is suing OpenAI, the creator of the artificial intelligence chatbot, ChatGPT, for alleged copyright infringement on their work through ChatGPT. The Canadian Broadcasting Corporation and other major news outlets claim that OpenAI is illegally using their content. The joint suit was filed in the Ontario Superior Court of Justice by five of the country's major news companies, including the publishers of its top newspapers, newswires, and the national broadcaster. This is the first such lawsuit in Canada, similar to a suit against OpenAI and Microsoft in the United States in 2023 by The New York Times, which claimed copyright infringement of news content related to AI systems. Both companies have denied the suit's claims.

NEW YORK POST
-President-elect Donald Trump is determined to release Hamas-held hostages and support a ceasefire deal in Gaza before he takes office. Senator Lindsey Graham stated that Trump is focused on the hostages issue and wants the killing to stop and the fighting to end. Graham hopes that President Trump and the Biden administration will work together during the transition period to release the hostages and achieve a ceasefire. She visited the Middle East twice in the last month, meeting with Saudi Crown Prince Mohammed Bin Salman and Israeli Prime Minister Benjamin Netanyahu. Graham's visit comes after visiting the Middle East twice in the last month.
-JPMorgan Chase CEO Jamie Dimon has been communicating with Donald Trump through secret back channels, helping him develop a policy agenda before and since his White House victory. The 68-year-old Wall Street titan, who grew up in Queens, New York City, has acted as a "sounding board" for the incoming commander-in-chief's economic manifesto. Trump's inner circle held "no-holds-barred conversations" with Dimon, who was rumored to be eyeing a government job himself. The secret back channel focused on plans for cutting government spending, banking regulation, taxes, and trade.

FT : Traders pay record premium for European gas next summer

Traders pay record premium for European gas next summer
Unusual price relationship could make it harder to refill EU storage as Russian supplies dwindle

European gas traders expect prices next summer to be higher than the following winter, an unusual bet that reflects the steep cost of refilling the continent’s storage facilities as it tries to wean itself off Russian supplies.

Natural gas in Europe has historically tended to be cheaper in the summer when demand is lower. That has incentivised traders to buy in the hotter months and store gas to sell at a profit during the winter peak heating season.

However, gas for delivery next summer is now being priced at a record premium to the winter that follows. That gap reflects an expectation that Europe will draw heavily on its gas storage during the current winter, and will then have a hard time restocking in the summer months.


The abnormal price relationship “is itself exacerbating worries about how Europe will manage to fill storage in summer 2025,” said Natasha Fielding, head of European gas pricing at Argus Media, a pricing agency.

Expensive summer gas “removes the commercial incentive” to rebuild stockpiles, she added.

In late November, the price of the European benchmark Title Transfer Facility in the summer of 2025, assessed by Argus, traded at a premium of more than €4 per megawatt hour to the winter 2025-26 price, the biggest premium ever to the winter price at this time of year.

Russia shut down the majority of its pipeline gas supplies to the EU in the run-up to and aftermath of the invasion of Ukraine in 2022.

In response, Brussels brought in a rule requiring member states to fill their gas storage to 80 per cent of capacity by the start of each November. Traders say the EU target, which has since been raised to 90 per cent, was pushing summer prices higher.

The mandate was not an issue in the past two years as Europe exited winter with record gas storage levels, lessening the scale of the summer top-up operation.

But analysts are expecting Europe to exit this winter with lower levels of gas than the previous two, and potentially much lower if much colder weather sets in.

The EU’s gas was 86 per cent full as of Wednesday, 10 percentage points below the same time last year. The rate of drawdown of reserves from the start of winter — typically October in the gas market — is at its fastest since 2016, according to data from Gas Infrastructure Europe, an industry body.

Traders are also bracing for a halt to Russian supplies coming through Ukraine, one of the two remaining pipeline routes to western Europe, when a transit agreement expires at the end of the year. The other route, via Turkey, may also be affected by US sanctions on Gazprombank, the lender that handles the bulk of Russia’s overseas energy revenue.


If the summer price premium persists, EU regulators are likely to mandate the purchase of more gas, said analysts at consultancy Energy Aspects. 

At the height of the energy crisis in 2022, some European governments ordered domestic companies to buy gas from the global market at record high prices in order to meet the storage mandate. 

The high summer gas price is a reflection of traders “speculating that the government will intervene again and fill storages at whatever cost, even if it is unprofitable”, said a gas trader.

FT : OpenAI targets 1bn users in next phase of growth

OpenAI targets 1bn users in next phase of growth
ChatGPT-maker aims for big boost from new AI products, Apple partnership and infrastructure investment

OpenAI is betting on a suite of new AI products, building its own data centres and a crucial partnership with Apple to supercharge its next phase of growth, as it targets reaching 1 billion users over the coming year.

The San Francisco-based group, whose popular ChatGPT chatbot has rocketed to 250mn weekly active users since its launch two years ago, plans to expand further through launching so-called AI “agents”, its own AI-powered search engine and ChatGPT’s integration with Apple devices.

“[In 2025] we will be coming into our own, as a research lab serving millions . . . hoping it can be billions of consumers around the world,” Sarah Friar, the company’s chief financial officer, told the Financial Times.

The goal comes as the nine-year-old start-up recasts itself as global technology giant and prepares for what founder and chief executive Sam Altman describes as the “Intelligence Age”.

Having raised more than $6bn of investment at a $150bn valuation in October — the highest for a start up in Silicon Valley’s history — Friar said OpenAI would continue to raise “more money”, including both equity and debt.

“In 74 days [since joining the company in June], we put ten billion of liquidity on the balance sheet. So that was my way of saying, hey, I’m going to get stuff done too,” she said.   

She added: “We’re in a massive growth phase, it behoves us to keep investing. We need to be on the frontier on the model front. That is expensive.”

To achieve its goals, OpenAI plans to invest in building clusters of data centres in parts of the US midwest and south-west, according to Chris Lehane, OpenAI’s new policy chief.

This push to build its own AI infrastructure follows a similar strategy by Big Tech rivals such as Google and Amazon. Lehane said “chips, data and energy” are the critical resources required to succeed in the AI race.

OpenAI has transformed rapidly in the 12 months since Altman was ousted by the company’s board, and then subsequently reinstated as chief executive last November.

It has brought on its first financial and product leaders, increased headcount by five times to more than 2,000 people, and triggered a complicated transition from a non-profit to a for-profit business model.

While OpenAI has lost key executives across its research and safety teams, including three of its original co-founders this year and high-profile technical leaders, such as Ilya Sutskever and Mira Murati, it has made way for a wave of new engineers and leaders.

Many of the new team have an expertise in building and monetising consumer products. This has led to a dual focus: a long-term research vision and short-term product goals as it focuses on ramping up revenue-generating products to outpace its ballooning costs.

It is spending well over $5bn a year and “not close to breaking even” due to the costs related to building AI models, according to people with knowledge of the group’s finances.

The newer recruits say they are still guided by OpenAI’s “mission” of building and distributing artificial general intelligence — software with cognitive capabilities superior to humans — but are tasked with deploying real-world utility in the near-term. 

“The last couple of years, we have had a really big inflection point in the quality of intelligence that can now be made into products that are actually useful for people,” said Srinivas Narayanan, vice-president of engineering at OpenAI, who joined last year from Meta. “That’s . . . why I’m here.”

The launch of AI agents — chatbot-like assistants that help execute tasks on the web, ranging from information gathering to booking or purchasing items — will be a key focus for 2025, according to Friar.

“Agentic has got to be the word of the year . . . It could be a researcher, a helpful assistant for everyday people, working moms like me. In 2025 we will see the first very successful agents deployed that help people in their day to day,” she said.

Rivals including Google, Anthropic and OpenAI’s biggest backer, Microsoft, have all signalled intentions to launch their own AI agents over the coming year.

Meanwhile, ChatGPT’s launch across Apple’s billions of devices, which began its rollout in the US last month, is core to driving a big jump in the number of users.

One of OpenAI’s major venture capital investors noted that the goal of 1bn users could be quickly reached because of this partnership.

“[OpenAI] are already at a few hundred [million] active users today without spending on marketing,” the investor said. “Apple has 2bn iPhones globally and want to push a new AI phone. The path to getting 1bn users with ChatGPT in their pocket is not that farfetched. If you get to that threshold, you’re competing with Google and Facebook.”

Meanwhile, OpenAI will also have to navigate an increasingly complex political landscape.

Lehane, a veteran political strategist who cut his teeth in the Clinton White House, will need to contend with the incoming President Donald Trump’s close adviser and OpenAI’s former co-founder Elon Musk, who runs his own AI company xAI, and is expected to help shape federal AI policy.

Musk recently filed a lawsuit against OpenAI and its backer, Microsoft, accusing Altman of “deceit of Shakespearean proportions” and seeking to void its commercial partnership with Microsoft. 

“[Musk] is obviously a unique personality at this moment in time. I think the way we think about it is we control what we can control,” Lehane told the FT.

Despite the public conflict with Musk, he said OpenAI and the Trump team were aligned on AI’s role in national security and economic competitiveness.

Lehane wants OpenAI to take the lead in building US-led “democratic” AI at scale, compared to a Chinese-led version of the technology.

“We’ve had conversations with the transition team . . . both during the campaign and after,” he said.

“This administration has talked . . . about the imperative of . . . US-led AI prevailing over Chinese-led AI. And if you want that to happen as the US government . . . then OpenAI is going to have to be in the middle of that conversation.”

Lehane believes the next few years will usher in a global, historical transition — a period when technology evolves at a pace that societies will struggle to adapt to.

Governments will need to develop new public-private partnerships in AI, similar to an electric utilities model, to fairly distribute the technology and its benefits, he added.

“Part of this company’s responsibility and role, is to . . . potentially shape those conversations and form those conversations, and hopefully be able to find some of the answers as we move forward,” said Lehane.