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Roche's Deal Should Sound Early Warning Ascribing Big Values to Early-Stage Drugs Can Be Hazardous
Early-stage drug deal-making is disconcerting. Rarely in other sectors do companies shell out vast sums for assets that could quite possibly amount to nothing.
Take Roche's RO.EB -0.10% agreement Wednesday to pay $725 million, plus up to $1 billion in milestone-based payments, for closely-held U.S. biotech firm Seragon Pharmaceuticals. The San Diego-based company was formed only last year and has one breast cancer drug in early stage trials.
Roche can get away with splashing out, but such deals should still give health care investors pause.
Roche is the acknowledged market leader in oncology. It dominates the treatment of one type of breast cancer, known as HER-2 positive which accounts for about 30% of cases. Seragon's putative product targets cancers which depend on estrogen and the estrogen receptor to grow, representing about 60% of the market. Roche, which given its substantial pipeline doesn't tend to splurge on buying others' early-stage work, may be trying to catch up or may need part of Seragon's intellectual property.
But the risks are substantial. Early-stage assets take many years to prove their worth: some 90% of drugs in phase one clinical trials—as Seragon's product is—just won't make it to market.
In simple monetary terms, Roche can afford it: the company generates about 14 billion Swiss francs ($15.7 billion) in free cash flow a year and should move into a net cash position in the next 12 months. And, ultimately, buying Roche's stock is a bet on the company's oncology expertise and judgment. At 16.5 times forecast 2015 earnings, Roche's shares trade at a slight premium to the global pharmaceutical sector but below where some competitors in the hot area of immuno-oncology are trading, such as Bristol Myers-Squibb BMY -0.06% or AstraZeneca. AZN.LN +1.17%
The question is whether deals such as the one for Seragon further fuel investors' conviction in biotech's resurgence and improving success in research and development. The global pharma sector's forward earnings multiple has expanded to almost 16 times, up from less than 11 times two years' ago, in part because investors believe the industry's R&D machine is again producing the goods.
That, combined with eye-catching transactions such as Roche's, could make investors more willing to give unproven treatments the benefit of the doubt, ascribing big values to early-stage drugs. Just remember that most still won't merit it.
Gapping down In reaction to disappointing earnings/guidance: CAMP -13.3%, PAYX -1.3%.
Other news: MCP -10.1% (move attributed to cautious blog mention), MZOR -6.8% (reports orders for four renaissance systems during the Q2), GPRO -3.7% (cautious Barron's mention - discusses Shark Tank's O'Leary potential short stance), ORAN -3.7% (Jamie Dimon sends letter to employees and shareholders announcing diagnosis of throat cancer), JPM -0.6% (Jamie Dimon sends letter to employees and shareholders announcing diagnosis of throat cancer), TE -0.5% (prices 15.5 mln shares of common stock at $18.10 per share), MNKD -0.5% (cautious Barron's mention).
Analyst comments: VE -2.5% (downgraded to Equal-Weight from Overweight at Morgan Stanley), OHI -1.3% (downgraded to Neutral from Buy at Goldman), HOG -1.8% (downgraded to Mkt Perform from Outperform at Raymond James), MM -1.1% (downgraded to Equal Weight from Overweight at Evercore), BMY -0.9% (downgraded to Equal Weight from Overweight at Barclays ), HRL -0.9% (downgraded to Neutral from Outperform at Credit Suisse), USB -0.8% (downgraded to Neutral at Robert W. Baird).