>>> US Gapping up

Gapping up
In reaction to earnings/guidance
:
  • AGYS +19.6%, EXP +6.5%, AS +2.9%, BILI +1.3%, CMBT +7.7%, ZBIO +5.7%, HSAI +1.2%
Other news:
  • RLAY +10.6% (Announced promising Phase 2 zovegalisib data in vascular anomalies, showing 60% volumetric response and supportive safety profile)
  • GILT +7.9% (Reached milestone with Boeing toward offering Sidewinder electronically steered antenna as future line-fit in-flight connectivity solution)
  • INFU +3.9% (Authorizes a new $20 million stock repurchase program running from July 1, 2026 through June 30, 2028.)
  • WVE +3.9% (Announces positive RestorAATion-2 trial update as WVE-006 achieved MZ-like phenotype with biweekly and monthly dosing)
  • ECX +2.9% (Announced strategic framework agreement with May Mobility to develop and deliver autonomy-enabled vehicles and exclusive AV technology components.)
  • TLX +2.7% (Completes patient enrollment for IPAX-2 study of TLX101-Tx in newly diagnosed glioblastoma; no dose-limiting toxicities observed.)
  • MLYS +2.2% (Announced Phase 3 Launch-HTN lorundrostat data in hypertension and CKD will be presented orally at ESH 2026.)
  • GDRX +2.0% (Integrated its discounts into TrumpRx.gov's expanded generic drug price transparency platform covering more than 600 medications.)
  • CGEM +1.9% (Receives FDA orphan drug designation for CLN-049 in relapsed/refractory acute myeloid leukemia.)

>>> US Research Calls I

Research Calls I
  • Upgrades:
    • American Tower (AMT) upgraded to Outperform from Market Perform at Bernstein, tgt $207
    • Assured Guaranty (AGO) upgraded to Buy from Neutral at UBS, tgt $94
    • Credicorp (BAP) upgraded to Buy from Hold at HSBC, tgt $350
    • Jazz Pharmaceuticals (JAZZ) upgraded to Buy from Neutral at UBS, tgt $307
    • Progyny (PGNY) upgraded to Buy from Hold at Canaccord, tgt $30
    • StubHub Holdings (STUB) upgraded to Buy from Neutral at Guggenheim, tgt $12.50
  • Downgrades:
    • Biofrontera (BFRI) downgraded to Speculative Buy from Buy at Benchmark, tgt $3
    • CrowdStrike (CRWD) downgraded to Sell from Buy at DZ Bank, tgt $500
    • Fortinet (FTNT) downgraded to Hold from Buy at DZ Bank, tgt $125
    • James River Group Holdings (JRVR) downgraded to Neutral from Buy at UBS, tgt $4.75
    • The Hanover Insurance Group (THG) downgraded to Market Perform from Outperform at BMO Capital, tgt $203
  • Others:
    • Alnylam Pharmaceuticals (ALNY) initiated with a Buy at Citigroup, tgt $380
    • Ascendis Pharma (ASND) initiated with a Buy at Citigroup, tgt $355
    • BioMarin Pharmaceutical (BMRN) initiated with a Buy at Citigroup, tgt $75
    • BridgeBio Pharma (BBIO) initiated with a Neutral at Citigroup, tgt $82
    • CG Oncology (CGON) initiated with a Peer Perform at Wolfe Research
    • Corpay (CPAY) initiated with a Buy at Loop Capital, tgt $406
    • CytomX Therapeutics (CTMX) initiated with an Outperform at Wolfe Research, tgt $6
    • Cytokinetics (CYTK) initiated with a Buy at Citigroup, tgt $99
    • Interface (TILE) initiated with a Buy at Benchmark, tgt $36
    • Ionis Pharmaceuticals (IONS) initiated with a Buy at Citigroup, tgt $115
    • Lightspeed POS (LSPD) reinstated with an Underperform at BofA Securities, tgt $10
    • Mirum Pharmaceuticals (MIRM) initiated with an Outperform at Wolfe Research, tgt $145
    • NeOnc Technologies (NTHI) initiated with a Buy at Alliance Global, tgt $13
    • Oklo (OKLO) initiated with a Peer Perform at Wolfe Research
    • Pilgrim's Pride (PPC) reinstated with a Neutral at UBS, tgt $30
    • Rapport Therapeutics (RAPP) assumed with a Buy at Truist, tgt $56
    • Tyra Biosciences (TYRA) initiated with a Peer Perform at Wolfe Research
    • X-energy (XE) initiated with a Hold at Jefferies, tgt $28
    • X-energy (XE) initiated with a Buy at Guggenheim, tgt $57
    • X-energy (XE) initiated with a Buy at TD Cowen, tgt $35
    • X-energy (XE) initiated with a Buy at UBS, tgt $40
    • X-energy (XE) initiated with an Overweight at JPMorgan, tgt $38
    • X-energy (XE) initiated with an Overweight at Morgan Stanley, tgt $41
    • X-energy (XE) initiated with a Peer Perform at Wolfe Research
    • Zeta Global Holdings (ZETA) reinstated with a Buy at BofA Securities, tgt $24

FT : Mango founder’s son detained over father’s mountain death

Mango founder’s son detained over father’s mountain death
Billionaire Isak Andic died while hiking with son Jonathan in 2024

The son of Mango founder Isak Andic has been detained by police in Spain over an investigation into his billionaire father’s death during a mountain hike in 2024.

Jonathan Andic, who was the Spanish fashion retailer’s chief executive during an unsuccessful stint in the mid-2010s, was taken into custody on Tuesday, police in Catalonia confirmed.

He had already been placed under investigation in connection with the possible murder of his father, who plunged to his death in December 2024 when the two were hiking alone in the Catalan mountains.

Isak Andic, who was born in Turkey, was Mango’s non-executive chair and, according to Forbes, was one of Spain’s wealthiest people with a fortune of €4.5bn when he died at the age of 71.

Jonathan Andic and his two sisters own 95 per cent of Mango, with the remaining 5 per cent in the hands of Toni Ruiz, its chief executive. Jonathan has a seat on the company’s board but no executive role.

The entrepreneur founded the business that became Mango as a blouse importer in Catalonia in the 1970s. He turned it into a global empire with annual sales of €3.8bn in 2025, second in size in the Spanish fashion business only to Zara-owner Inditex.

The Andic family has consistently maintained that the 100 metre fall that led to Isak Andic’s death was accidental.

In a statement on Tuesday, the Andic family said: “Jonathan Andic has been requested to provide a statement relating to the accident of 14 December 2024. He continues to co-operate fully with judicial proceedings. This process remains under judicial secrecy, we have nothing further to say at this time.”

>>> US Early premarket gappers

Early premarket gappers
  • Gapping up:
    • AGYS +16.6%, EVTC +11.2%, STC +10.0%, ANDG +7.2%, ENLT +5.3%, VPG +5.2%, WVE +4.8%, WPP +3.1%, TLX +2.7%, AS +2.6%, NOMD +1.6%, XE +1.5%, TOYO +1.4%, LMB +1.2%, HD +1.2%
  • Gapping down:
    • PKX -7.3%, XP -5.0%, BRUN -4.8%, LI -4.8%, AKAM -4.2%, NBIS -3.9%, PAGP -3.1%, TS -2.9%, STX -2.0%, VRT -1.6%, BEKE -1.6%, CTRE -1.3%

TEchCrunch : SandboxAQ brings its drug discovery models to Claude — no PhD in co

SandboxAQ brings its drug discovery models to Claude — no PhD in computing required

Drug discovery is one of the most expensive pursuits in modern industry. Finding a single viable molecule can take a decade and cost billions, and most candidates still don’t make it. A generation of AI startups has promised to fix that — most have made the problem less painful for researchers, who are already technically sophisticated enough to use the tools.

But SandboxAQ thinks the bottleneck isn’t the models. It’s the interface.

The company has teamed up with Anthropic to integrate its scientific AI models directly into Claude — putting powerful drug discovery and materials science tools behind a conversational interface that requires no specialized computing infrastructure to use.

Founded roughly five years ago as an Alphabet spinout, SandboxAQ counts Eric Schmidt, Google’s former CEO, as its chairman. The company, which has raised more than $950 million from investors, has built out a number of different business lines, including a cybersecurity business.

One of the more unique things SandboxAQ does, however, is produce large quantitative models, or LQMs. These proprietary models are “physics-grounded,” meaning they’re built on the rules of the physical world rather than patterns in text. They can run quantum chemistry calculations and simulate both molecular dynamics and microkinetics, the study of how chemical reactions unfold at the molecular level. That matters because it tells researchers how candidate molecules are likely to behave before anyone sets foot in a lab.

“Trained on real-world lab data and scientific equations, LQMs are AI models engineered for the quantitative economy, a $50+ trillion sector spanning biopharma, financial services, energy, and advanced materials,” the company said in a news release that strongly suggests Sandbox AQ isn’t building another chatbot or code assistant — it’s chasing the economy that AI is supposed to transform.

Chai Discovery and Isomorphic Labs — both well-funded bets on better models — have focused on the science. SandboxAQ is focused on who can actually use it.

“For the first time, we have a frontier [quantitative] model on a frontier LLM that someone can access in natural language,” Nadia Harhen, SandboxAQ’s general manager of AI simulation, told TechCrunch. Previously, users of SandboxAQ’s LQMs would have had to provide their own digital infrastructure to run the models.

SandboxAQ’s customers tend to be computational scientists, research scientists, or experimentalists. Generally, these people work at large pharmaceutical or industrial companies and are searching for new materials that can become marketable products.

“Our customers come to us because they’ve tried all the other software out there, and the complexity of their problem is such that it didn’t work or didn’t yield positive results for them when that translation went to take place in the real world,” said Harhen.

>>> Europe : Brokers Upgrades & Downgrades - 19th of May 2026 V2(+)

>>> Up
* AMS-Osram Raised to Overweight at JPMorgan
* BE Semiconductor PT Raised to 300 euros at Morgan Stanley
* DSV Price Target Raised to DKK 2,250 from DKK 2,240 by Bank of America
* First Quantum Minerals Raised to Overweight at Morgan Stanley
* FLSmidth Raised to Buy at UBS; PT 550 kroner
* Intrum Raised to Buy at UBS; PT 28 kronor
* Jungheinrich PT Raised to 48 euros from 46 euros at Bernstein
* Kion Raised to Buy at DZ Bank; PT 59 euros (+)
* Knorr-Bremse Raised to Buy at Citi; PT 123 euros
* Sainsbury Raised to Equal-Weight at Morgan Stanley; PT 345 pence
* Siltronic PT Raised to 110 euros at Bankhaus Metzler (+)
* Soitec PT Raised to 200 euros from 70 euros at Morgan Stanley
* Springvest Raised to Accumulate at Inderes; PT 9.20 euros

>>> Down
* Adecco Cut to Sell at UBS; PT 13 Swiss francs
* Barratt Redrow Cut to Equal-Weight at Barclays; PT 260 pence
* Bellway Cut to Equal-Weight at Barclays; PT 2,020 pence
* Cadeler Cut to Neutral at SB1 Markets; PT 70 kroner
* Gerresheimer Cut to Hold at Jefferies; PT 26.80 euros
* GRK Infra Cut to Accumulate at Inderes; PT 16 euros

>>> Initiation
* Auroora Group Rated New Buy at Nordea; PT 7.20 euros
* BEWI Rated New Buy at Arctic Securities; PT 24 kroner
* Coffee Stain Group Rated New Buy at Pareto Securities (+)
* Jet2 Rated New Underperform at BofA (+)
* Medicover Rated New Buy at SB1 Markets; PT 270 kronor
* Volvo Car Rated New Neutral at SB1 Markets; PT 25 kronor

>>> Call
* 3i Group Target Cut at Deutsche Bank, Sees it Trading as Retail (+)
* Goldman’s Oppenheimer Sees ‘Speed Bump Risk’ for Equity Markets
* AMS-Osram Upgraded at JPMorgan on Upside From AI Photonics
* Gerresheimer Cut at Jefferies on Continued Market Overhangs
* Knorr-Bremse Raised to Buy at Citi After Slipping From Highs
* Societe Generale Strategists Double Down on Euro Area Small Caps (+)
* Tesco is UK Grocery Winner, Sainsbury Caught in Middle, MS Says

>>> What to look at today - 19th of Mayl 2026

Stocks headed for a third day of declines as little progress on de-escalating the situation in Iran kept inflation concerns front and center, with oil prices and bond yields remaining elevated. MSCI’s All Country World Index dropped 0.1%, with Asian shares falling 0.7% as concerns around Iran lingered even after President Donald Trump said he was holding off on fresh strikes on the Islamic Republic. Technology shares were weak, with South Korean stocks tumbling 3.6% after a gauge of chipmakers dropped during the US session. Contracts for the Nasdaq 100 Index also retreated. While Brent crude fell 2% to about $110 a barrel Tuesday after Trump’s comments, the commodity is still up 80% this year with the vital Strait of Hormuz still effectively shut. Higher oil prices and concerns about inflation are weighing on bonds, sending yields of government debt from Japan to the US to multi-year highs. The yield on the US 30-year bond edged up one basis point to 5.13%, having climbed to the highest since 2023 in the prior session. On Monday, yield on Japan’s 30-year government debt surged to its highest since the maturity was first sold in 1999. Tuesday’s moves followed weeks of volatility sparked by the US-Iran conflict and the closure of the Strait of Hormuz, with investors brushing aside geopolitical risks as the AI-driven rally pushed equities higher. Markets now face a key test as bond yields from Japan to the US climb and crude oil prices remain elevated, increasing the likelihood the Federal Reserve will keep interest rates higher for longer. Rising US bond yields pose a threat to Asia’s stock rally, as growing inflation fears offset ongoing optimism over benefits from the artificial intelligence boom. Over the past five years, the MSCI Asia Pacific Index has fallen in 16 of the 19 weeks when the US 10-year Treasury yield rose by 20 basis points or more, losing 1.6% on average, according to data compiled by Bloomberg. Earlier Monday, both the US and Iran said they’d rejected fresh offers as insufficient to secure a deal. The White House said a proposal delivered by Tehran through mediators Sunday lacked meaningful improvement, Axios reported. Iran, meanwhile, indicated US demands are unacceptable. Trump has repeatedly threatened renewed military action against Iran without following through. There was no immediate confirmation from Tehran of renewed talks. Trump said the US was prepared to attack if an acceptable deal wasn’t reached but didn’t set a deadline. Elsewhere, the US on Monday issued a new waiver allowing the sale of Russian crude oil and petroleum products that are already loaded on tankers, days after the previous one lapsed. Treasury Secretary Scott Bessent said in a post on X that the new general license “will help stabilize the physical crude market.” US After Hours AGYS +14.2% sharply higher on earnings; NOMD +1.1% on insider purchases; XP -4.3% lower on earnings.

Nikkei -0.76% Hang Seng +0.39% CSI -0.52% Shanghai +0.02% Shenzen -0.49%

Eur$ 1.1654 CNH 6.8041 CNY 6.8015 JPY 158.98 GBP 1.3411 CHF 0.7858 RUB 72.6796 TRY 45.5810 WTI$ 107.44 Gold 4,540 -0.21% BTC 76,822 -0.04% ETH 2,132 +0.77%

S&P -0.31% Nasdaq -0.53% EuroStoxx +0.12% FTSE +0.14% Dax +0.06% SMI +0.17%

Macro :
- BlackRock Strategists Lift DM Stocks on AI Earnings Optimism
- Goldman’s Oppenheimer Sees ‘Speed Bump Risk’ for Equity Markets
- Nokia, Engie Well Placed for Euro Stoxx 50 Entry, JP Morgan Says
- Druckenmiller, Soros Family Offices Bet on Energy as War Erupted
- UK Prepares to Inject £6b for Jet Project With Japan, Italy: FT
- Citadel Securities’ Rubner Sees Risk of Flow Unwind in US Stocks
- US Approves Possible Military Sales to South Korea Worth $4.2b
- China's auto dealer inventory level reported by CADA Rises to 1.89 Months

Keep an eye on :
- ACLN SW : Accelleron Launches CHF100 Million Share Buyback Program
- ACS SM : ACS Starts Combined Equity Offering of About 16.6m Shares: Terms, Spain’s ACS Offers €2.2 Billion Stake to Fund Data Center Plans ADP April Passenger Traffic -4.9%
- ADP FP : ADP April Passenger Traffic -4.9%
- AEVS SW : Aevis Victoria Posts Growth in Q1 Net Profit, Revenue
- AIXA GY : AIXTRON receives multiple orders for G10-AsP MOCVD Systems from Lumentum to support expansion of High-Speed Optical Solutions fo
- AKAK US : Akamai to Offer $2.6b of Convertible Senior Notes
- MT NA : ArcelorMittal Offers €623 Million Stake in Steel Tube Producer
- AML LN : Aston Martin Names Andrea Baldi as Chief Commercial Officer
- T US : AT&T Remains on Track for 2026, Multiyear Guidance
- BAKKA NO : Bakkafrost Sees FY Harvest About 117,000 Metric Tons
- BYG LN : Big Yellow Group FY Adjusted Pretax Profit Meets Estimates
- BIOMAR DC : Publication of Offering Circular and indicative price range for the Initial Public
- BA US : US Approves Possible Military Sales to South Korea Worth $4.2b
- BOSN SW : Bossard Says Stephan Zehnder Will Step Down as CFO at End-March
- CAVA US : Cava Sales Accelerating, Helped by New Menu Items: Preview
- CMTB BB : Euronav Q1 EPS $1.27 Beats $1.16 Estimate, Sales $519.630M Beat $410.212M Estimate
- DHER GY : Delivery Hero Says Uber Now Owns 19.5% of Issued Capital
- DHER GY : Uber leaves door open to Delivery Hero takeover by increasing stake - FT
- DOCS LN : Dr Martens FY Revenue Meets Estimates
- EIX US : Edison International, PG&E Drop as California Wild Fire Spreads
- ENEL IM : Enel buys seven US solar power plants for USD140 million
- EQNR NO : Equinor Issued With Order by Norway’s Ocean Industry Authority
- ESLT IT : TKMS, Elbit Sign Cooperation Pact Eyeing European Defense Market
- ENGI FP : Nokia, Engie Well Placed for Euro Stoxx 50 Entry, JP Morgan Says
- EQT SS : EU Confirms EQT to Lead €5b Scaleup Europe Fund
- EGLA IM : Eurogroup Laminations 1Q Revenue EU203.5M Vs. EU221.1M Y/y
- GOOGL US : Blackstone to Invest $5B in Google AI Cloud Joint Venture
- GSF NO : Grieg Seafood Cuts FY Harvest Forecast
- GUBRA DC : Gubra Appoints Adam Lange as Head of Investor Relations
- HNSA SS : Hansa Biopharma enters into EUR115 million licensing agreement with SERB Pharmaceuticals for IDEFIRIX in Eur
- HNSA SS : SERB Buys Idefirix Rights for Europe, MENA From Hansa Biopharma
- MBH3 GY : Hermle 1Q Sales EU110.9M Vs. EU97.2M Y/y
- HIMS US : Hims & Hers Prices Upsized $350m Convertible Sr Notes Due 2032
- HBH GY : Hornbach Holding FY Adjusted Ebit EU264.7M
- KER FP : Saint Laurent’s chief says luxury must work harder to retain customers - FT
- LAGRB SS : Lagercrantz 4Q Net Revenue Meets Estimates
- LLOY LN : Lloyds Plans Expansion into US Infrastructure Lending: FT
- MC FP : Dior boss Delphine Arnault says brand will be ‘cautious’ on pricing - FT
- MATAS DC : Matas Reports 4Q Revenue of DKK 1.98 Billion, Compared With FactSet Estimates of DKK 1.97 Billion
- NANOFH FH : Nanoform Q1 2026 report - Record first quarter revenue, income and gross margin, first exclusivity deal signed
- NOKIA FH : Nokia, Engie Well Placed for Euro Stoxx 50 Entry, JP Morgan Says
- NDX1 GY : Nordex Group receives new orders totaling 82 MW from Westfälisch-Niedersächsische Energie WNE in Germany
- OHB GY : Satellite Firm’s 600% Rally Opens Funding Options: ECM Watch
- ROS AV : Fast-Moving California Fire Expands, Spurs Evacuations
- GLE FP : French ACPR Watchdog Fines SocGen EU20M Over Insurance Contracts
- SCHO DC : Aktieselskabet Schouw & Co.: Publication of Offering Circular and indicative price range for the Initial Public Offering of the
- SDR LN : Soderberg Joins Suitors for Schroders’ Benchmark Unit: Sky
- SpaceX IPO : SpaceX Contractor Dies at Rocket Company’s Texas Headquarters
- SQN SW : Swissquote to Implement 1:10 Share Split From May 26
- TSLA US : Musk Says ‘Activist Judge’ Ruling Creates ‘Terrible Precedent’
- TKMS GY : TKMS, Elbit Sign Cooperation Pact Eyeing European Defense Market
- UCB BB : UCB Says Bimzelx Shows Better Outcomes Over Skyrizi in PSA Trial
- VK FP : ArcelorMittal Offers €623 Million Stake in Steel Tube Producer
- VAR NO : Vår Energi ASA's share saving plan allocates shares
- ZAL NO :

>>> Europe : Brokers Upgrades & Downgrades - 19th of May 2026

>>> Up
* AMS-Osram Raised to Overweight at JPMorgan
* BE Semiconductor PT Raised to 300 euros at Morgan Stanley
* DSV Price Target Raised to DKK 2,250 from DKK 2,240 by Bank of America
* First Quantum Minerals Raised to Overweight at Morgan Stanley
* FLSmidth Raised to Buy at UBS; PT 550 kroner
* Intrum Raised to Buy at UBS; PT 28 kronor
* Jungheinrich PT Raised to 48 euros from 46 euros at Bernstein
* Knorr-Bremse Raised to Buy at Citi; PT 123 euros
* Sainsbury Raised to Equal-Weight at Morgan Stanley; PT 345 pence
* Soitec PT Raised to 200 euros from 70 euros at Morgan Stanley
* Springvest Raised to Accumulate at Inderes; PT 9.20 euros

>>> Down
* Adecco Cut to Sell at UBS; PT 13 Swiss francs
* Barratt Redrow Cut to Equal-Weight at Barclays; PT 260 pence
* Bellway Cut to Equal-Weight at Barclays; PT 2,020 pence
* Cadeler Cut to Neutral at SB1 Markets; PT 70 kroner
* Gerresheimer Cut to Hold at Jefferies; PT 26.80 euros
* GRK Infra Cut to Accumulate at Inderes; PT 16 euros

>>> Initiation
* Auroora Group Rated New Buy at Nordea; PT 7.20 euros
* BEWI Rated New Buy at Arctic Securities; PT 24 kroner
* Medicover Rated New Buy at SB1 Markets; PT 270 kronor
* Volvo Car Rated New Neutral at SB1 Markets; PT 25 kronor

>>> Call
* Goldman’s Oppenheimer Sees ‘Speed Bump Risk’ for Equity Markets
* AMS-Osram Upgraded at JPMorgan on Upside From AI Photonics
* Gerresheimer Cut at Jefferies on Continued Market Overhangs
* Knorr-Bremse Raised to Buy at Citi After Slipping From Highs
* Tesco is UK Grocery Winner, Sainsbury Caught in Middle, MS Says

>>> Stoxx 600 Pre-Market Indications

  • Evolution (E3G1 TH) +3.7%
  • Aixtron (AIXA TH) +3.3%
  • Knorr-Bremse (KBX TH) +3.3%
  • Tomra (TMRA TH) +1.7%
  • Kion (KGX TH) +1.3%
  • Thales (CSF TH) -1.1%
  • Aurubis (NDA TH) -1.2%
  • Novo (NOV TH) -1.2%
  • TotalEnergies (TOTB TH) -1.2%
  • Yara (IU2 TH) -1.3%
  • HSBC (HBC1 TH) -1.4%
  • Rolls-Royce (RRU TH) -1.4%
  • ACS (OCI1 TH) -5%