FT : Regeneron head says weight-loss drugs could cause ‘more harm than good’

Regeneron head says weight-loss drugs could cause ‘more harm than good’
US biotech is researching treatments to reduce muscle loss from blockbuster diet medicines

The co-founder of Regeneron has warned that blockbuster weight-loss drugs could cause “more harm than good” unless the rapid muscle loss associated with the treatments is solved, as the US biotech pushes ahead with trials of muscle-preserving medicines.

Clinical studies suggest that patients treated with the new class of weight- loss drugs, known as GLP-1s, lose muscle at far faster rates than people losing weight from diet or exercise, exposing them to health problems, said George Yancopoulos, who also serves as Regeneron’s chief scientific officer.

For the two in every five patients who discontinue the treatments within a year, according to a 2024 JAMA study, this means that they are likely to rebound to their original weight with less muscle and a higher body fat percentage, “adding insult to injury”, said Yancopoulos.

“I do think that the GLPs should be viewed with a lot of concern in terms of the way they’re actually being used in the real world,” said Yancopoulos. “They could be leading to successive changes in body composition that could be creating more harm than good in the long term.”

Regeneron is among a growing list of drugmakers researching experimental drugs to preserve lean muscle mass in combination with GLP-1 drugs as a route into a potentially $130bn-a-year market that is dominated by Ozempic and Wegovy maker Novo Nordisk and Eli Lilly, the company behind Mounjaro and Zepbound.

Regeneron, a $111bn biotech that specialises in antibody treatments, is testing a drug called trevogrumab, which blocks the hormone myostatin, which limits muscle growth, in combination with Wegovy in mid-stage trials. There are 11 myostatin drugs in biotech pipelines, of which seven are being investigated for obesity, according to industry tracker Citeline.

Last year, Eli Lilly bought Boston-based biotech Versanis in a deal worth $1.9bn to get its hands on its muscle-preserving treatment to complement its weight-loss drugs. BioAge, a biotech with a muscle-regeneration drug that is partnered with Eli Lilly, listed last month and its share price is up 21 per cent.

Clinical data shows that 25 per cent of weight loss from Eli Lilly’s shot resulted from a reduction in lean body mass, including muscle, while 40 per cent of Novo Nordisk’s jab was due to a drop in lean body mass.

The US Food and Drug Administration advises that the drugs be used in combination with diet and exercise. Novo Nordisk said clinical data “[does] not indicate an association of greater lean body mass loss over fat mass loss with semaglutide treatment”. Eli Lilly did not immediately respond to a request for comment.

The first clinical data from Regeneron’s phase-two trial of trevogrumab is expected halfway through next year. Regeneron is also considering whether to advance a monthly GLP-1 injection to clinical trials, which it has tested in mice. Despite his concerns about the drug, Yancopoulos said Regeneron was “thinking about becoming players in the GLPs”.

“I’m not sure that the GLPs are really the true final answer here, because they could have significant long-term problems,” he added.

“We all want to have 10 more pounds of muscle, 10 less fat, but we could eat whatever we want — that’s the ideal world,” said Yancopoulos.

“We don’t all want to be nauseous and sick and losing muscle. I do think that . . . an ideal future is one where we achieve a better, healthier way of fighting back against metabolic disease.”

FT : Danone plans India expansion to close in on rivals Unilever and Nestlé

Danone plans India expansion to close in on rivals Unilever and Nestlé
The French consumer goods group’s presence in the country is ‘nowhere near where it should be’, says chief executive

Danone plans to expand in India as the French consumer goods group attempts to catch up with entrenched competition in the world’s fastest growing large economy.

The company’s presence in India, where it sells milk-powder protein and baby formula, is “nowhere near where it should be”, chief executive Antoine de Saint-Affrique told the Financial Times.

Danone, which also holds a minority stake in small Indian yoghurt making start-up Epigamia, is reassessing its India strategy. Investors are attracted to country’s large market, it is the world’s most populous nation with 1.4bn people, and manufacturing potential at a time when economic activity is faltering in China.

The French company has fallen behind global rivals Unilever and Nestlé in India’s fast-moving consumer goods industry, where revenues are estimated by a government promotion agency to hit $616bn by 2027.

De Saint-Affrique, who has led Danone since 2021, has been charged with turning around lagging performance following a period of boardroom turmoil that resulted in the ousting of his predecessor Emmanuel Faber.

Since then, Danone has sought to reverse falling sales volumes and under-investment. The company’s second-quarter sales volumes this year climbed 2.9 per cent on an annual basis, beating expectations.

“If you look at the top-three countries of Danone, it’s [the] US, China, France,” said de Saint-Affrique, speaking in the north Indian city of Chandigarh. He added that it was the company’s “ambition” for India to rank among the top five.

De Saint-Affrique, who was visiting India to announce a four-year €20mn investment to expand Danone’s existing plant in Punjab, warned that if companies do not scale in India over the next decade “you will be less relevant as a global player”.

The maker of Activia yoghurt and Evian bottled water has struggled to make inroads in India, the world’s biggest producer of dairy products, according to the Food and Agriculture Organization of the United Nations.

Harit Kapoor, lead consumer analyst at Investec India, described Danone’s history in the country as “stop-start” and said its current market share was “tiny”.

Danone’s 13-year partnership with Indian biscuit giant Britannia Industries, which is owned by the billionaire Wadia family, ended in 2009 following an acrimonious branding dispute. In 2018, the French company stopped producing fresh dairy and UHT products — sterilised, long-life goods that do not need refrigeration — in India.

“[Danone’s] brands are not highly penetrated, they are very, very small,” said Sachin Bobade, analyst at Mumbai-based Dolat Capital. “I’ve not seen their products frequently.”

Bobade said that India’s dairy market is not easy to penetrate. Dairy co-operatives, such as Amul brand owner Gujarat Milk Marketing Federation, control a 60 per cent share of Indian dairy product sales, according to estimates by Investec.

“Organically creating size in the Indian market is extremely hard,” said Investec’s Kapoor.

Danone is an “exceptionally late entrant”, he said. “The only way to build up quick scale, especially in say water or dairy, is to acquire.”

De Saint-Affrique said that Danone had a later start in the country compared with rivals, including his former employer Unilever, which has been operating in India for decades. “We are only at the start of our growth journey in India,” he said.

The chief executive did not rule out Indian acquisitions, but added: “There’s plenty of things that we can do organically.”

Danone’s experience in China and Indonesia, the company’s two biggest markets in Asia, gives the company “a good blueprint on what we could do in India”, de Saint-Affrique added.

China, North Asia and Oceania is Danone’s fastest-growing region, registering 8.4 per cent annual like-for-like sales growth in the second quarter. The company does not provide country specific data for India.

India is “of high interest to us”, said de Saint-Affrique. Last year, Danone appointed former Hindustan Unilever chair Sanjiv Mehta to its board as an independent director in a move to bolster its expertise of the region.

“I’ll be back probably in the next six months,” de Saint-Affrique said. “The market matters to us.”

>>> Barrons Summary

Cover:
-Tesla, once a leading car innovation company, is at risk of becoming just another auto maker. Elon Musk's vision of Tesla as the Apple of autos has led to its rapid growth, with the company building electric vehicles and selling everything from self-driving technology to solar panels and energy storage batteries. However, Tesla's EV lead has narrowed, and the company's aura of inevitability has diminished. Companies like Ford Motor, General Motors, Volkswagen, BMW, BYD, NIO, Toyota Motor, and Hyundai Motor make EVs, including hybrids, which Tesla has no desire to match. Tesla's high-tech gadgets and features are available in cars from Mercedes-Benz Group's Mercedes EQE to the more affordable Chevy Equinox. Tesla stock is currently 40% below its record high as EV growth decelerates globally.

Interview:
-Roger Ferguson, a former vice chair of the Federal Reserve (Fed), has a unique perspective on interest-rate cuts and hikes. Ferguson, who served from 1999 to 2006, was the only member of the Board of Governors in Washington after the 9/11 attacks. During the chaos and fear, Ferguson had to make key decisions to ensure the US banking system did not seize up. He refused to declare a bank holiday and instead stated that the Federal Reserve System was open and operating. Ferguson's early life was atypical for a Fed board member, as he grew up in a segregated neighborhood in northeast Washington, DC His mother was a public elementary-school teacher, and his father was a civilian cartographer. His father's upbringing during the Depression influenced his fascination with financial literacy, which he emphasized at the kitchen table.

Tech Trader:
-Alphabet's NotebookLM, part of Google Lab's NotebookLM project, is an AI-powered podcast tool that transforms content into a dialogue between two hosts. The tool, which sounds like science fiction, is available to users today. The feature has sparked a viral response on social media, with early adopters posting their favorite custom-made AI podcasts. NotebookLM product lead Raiza Martin suggested that the attention had overwhelmed Google's AI chip infrastructure. Andrej Karpathy, Tesla's former director of AI and OpenAI co-founder, wrote about his AI creation, describing it as his favorite podcast. NotebookLM has been steadily improved since its introduction last year, becoming a personal AI research assistant. The service allows users to upload up to 50 sources, including website links, PDF documents, MP3 audio files, and YouTube videos. After uploading sources, users can ask model questions based on the information in those sources. NotebookLM is powered by Google's most advanced AI model, Gemini 1.5 Pro, which offers greater memory capacity and the ability to take in more context from users.

The Trader:
-ResMed stock has been rallying since July, when Eli Lilly released data showing that one of its GLP-1 obesity drugs had significantly reduced the severity of obstructive sleep apnea (OSA). The market feared this would reduce demand for ResMed's various CPAP airflow machines, which patients wear during sleep to relieve the condition. However, the market realized that GLP-1 drugs were unlikely to damage ResMed's business, as less than half of the GLP-1 population has OSA and not all sufferers use face masks. ResMed's data shows that GLP-1 patients are more likely to use its machines when they start to focus on their respiratory health. The company has also acquired small software firms that provide data to patients and doctors, generating a small portion of total revenue but enabling patients to better understand the condition and limit their healthcare costs.
-The S&P 500 index has dropped 0.4% this week, while the Nasdaq Composite and Dow Jones Industrial Average have fallen 0.7% and 0.5% respectively. Military tensions in the Middle East have raised oil prices, but the market remains confident in the economy. The US added more jobs than expected in September, and the Federal Reserve is not afraid of the Fed's continued interest rate cuts. The S&P 500 is on track to close the week at 5717, still within reach of its record high of 5762. Several factors contribute to this, including the Fed cutting its federal-funds rate by a half-point in September to keep the economy growing, lower rates on bonds making stocks more attractive, and Nvidia's 1.1% gain after CEO Jensen Huang confirmed that the company's artificial-intelligence chips are in full production. This has pushed the S&P 500 up by double digits this year, including a 2.1% gain in September. This year's countertrend sets the stage for more gains throughout the rest of the year. After September gains, the market has risen in the fourth quarter 79% of the time, averaging an advance of 5.1%, according to Bank of America. If the S&P 500 rises in line with this average for the fourth quarter, it would end the year at just over 6000.

Features:
-Port workers in the US have been granted a 62% wage increase by port operators over the next six years, allowing ports from Maine to the Gulf of Mexico to reopen. The agreement, which ended a three-day port strike, will lift pay for some workers to levels similar to doctors. However, the situation is more complex than that. Dockworkers, represented by the International Longshoremen's Association, have some of the highest wages among blue-collar workers, with a top-scale longshoreman earning up to $39 an hour. The 62% raise would increase this number to $131,220 per year, before overtime and other factors. Dockworkers' wages vary widely depending on skill and seniority, with many operating multi-million-dollar container-handling equipment for a mere $20 an hour. Pay also depends on the number of hours, where, and when someone works, with after-hours or overtime shifts usually paid at higher rates. A report from the Waterfront Commission, a regulator for New York Harbor, showed that annual earnings for longshore workers in 2020 ranged from less than $25,000 to above $450,000.
-Hurricane Helene has caused significant financial losses for the auto industry, with General Motors shutting down all vehicle production at two factories in Flint, Michigan, and Arlington, Texas, due to supplier impacts. The affected factories employ over 10,000 workers and produce heavy-duty trucks and full-size SUVs, including the Chevy Silverado HD and GMC Sierra HD pickups, as well as the Chevy Tahoe, Suburban, and Escalade SUVs. Stellantis, the parent company of Jeep and Fiat, said its production was not affected by Helene. Ford F did not immediately respond to Barron's request for comment. GM did not comment on whether there would be additional shift cancellations next week. The total economic losses from Helene are estimated to be in the billions of dollars, with Gallagher Re estimating total economic losses at $35B. A preliminary estimate from Moody's put the total damage between $20B and $34B, including property damage and $5B to $8B in lost output due to building closures and power outages.

European Trader:
-Wall Street has been downgrading shares of Stellantis, parent company of Jeep and Chrysler, following disappointing financial guidance. The company's 2023 record was a disappointment for the company, with its full-year adjusted operating income margins at 5.5% to 7%, and free cash flow expected to be negative $5.6B to $11.2B. Stellantis is now considering a fresh look at expansions, with CFO Natalie Knight instructing her finance team to scrutinize requests for purchases from outside vendors to rein in expenses. Several other analysts have cut their price targets while maintaining their ratings. The average analyst price target is about $18 a share, down from about $20 a few weeks ago and about $26 entering 2024. 46% of analysts covering the stock rate shares Buy, with the average Buy-rating ratio for shares in the S&P 500 being about 55%. The problem for Stellantis is not with EVs or hybrids but with dealers' inventory levels getting too high. U.S. inventories for Dodge dealers ended August at almost 150 days of sales, up from 116 a year ago. The company has blamed poor marketing among other things, but the situation has angered dealers. Wall Street now expects 2024 operating profit to be below $13B, down by almost 50%.

Emerging Markets:
-Emerging market stocks are gaining momentum and are expected to continue their outperformance compared to U.S. stocks. The iShares MSCI Emerging Markets ETF has seen a 11% increase to just over $46 from its September 6 low, beating the S&P 500 index's 6% return over the same period. The Federal Reserve has cut interest rates to maintain U.S. economic growth, while China has implemented measures to boost its economy, including reducing cash bank reserves and lowering mortgage rates. These factors will support the Chinese economy and Chinese stocks, which represent a quarter of the market value of the Emerging Markets ETF. However, emerging market underperformance has become legendary, with the ETF returning just 3.2% over the past 15 years, compared to the S&P 500's 14% return.

Commodities:
-The oil market is on edge following a violent week in the Middle East, with traders making a record number of bullish options bets on Brent crude oil, with many wagering it will soar above $100 per barrel, more than 25% above current prices. Israel fired missiles at Hezbollah leaders in Beirut, the latest on targets in Lebanon after Israel killed Hassan Nasrallah last month. Hezbollah is backed by Iran, a major energy producer, which retaliated by bombing Israel earlier this week. President Joe Biden is discussing possible Israeli strikes on Iranian oil facilities in response. Brent crude, the international standard, gained 1% to $78.40 a barrel, the largest weekly gains since early 2023. The war in the Middle East has had minimal impact on oil prices for most of the past year, with oil production and refinery operations under threat.

Streetwise:
-CVS Health is facing challenges due to a decline in shares and a Federal Trade Commission report highlighting the expansion of profits by healthcare conglomerates and their middlemen in the drug business. The company should split into at least seven pieces, aggressively recombine, and cross-sell synergies into total addressable markets. If this doesn't work, CVS should consider turning the company off and then on again. The Magnificent Seven, a group of tech companies that recently led the US by stock market value, is not the case. The Pharma-Filled Five, including CVS, UnitedHealth, Cigna Group, and Humana, had combined revenue that equaled 22% of America's total healthcare spending last year, up from 14% in 2016. CVS is not lacking for business, as it has a similar revenue projection of $369B and $398B for this year. However, CVS's lost decade has left its market value at just $78B, indicating a need for a more strategic approach.

>>> Weekend Papers Summary

FINANCIAL TIMES
-Crude prices rose by almost 8% in the past week due to speculation that Israel or Iran could strike energy infrastructure in the Middle East, the world's most important oil-exporting region. Brent, the global oil benchmark, settled at $78.05 a barrel, marking the biggest weekly gain since January 2023. The surge came as escalating conflict in the Middle East fueled fears of violent disruption to exports in a region that produces a third of the world's crude. US President Joe Biden suggested Israel should consider other options, reducing the rally and rekindling fears of inflation. Iran exports 1.7M barrels of oil daily, mainly from a terminal on Kharg Island.
-The US economy added 254,000 jobs in September, surpassing expectations and causing traders to increase bets on the Federal Reserve's slower rate cut. The unemployment rate fell to 4.1%, a three-year high in July. The report suggests the Fed is on course to pull off a soft landing for the economy, which has weathered high inflation while maintaining robust growth and strong employment. The resilience of the labor market is also beneficial for vice-president Kamala Harris, who is tied in opinion polls with Republican nominee Donald Trump ahead of the upcoming presidential election.
-The US military has conducted multiple strikes on Houthi targets in Yemen, resuming offensive action amid growing fears of a wider Middle East conflict. The US Central Command carried out 15 strikes at various locations in the country, aiming to protect freedom of navigation and make international waters safer for US, coalition, and merchant vessels. The strikes against the Iranian-backed Houthis, who have controlled Yemen's north since 2015, came as Iran and the region braced for Israel's response to Iran's missile barrage against the country. The Iranian-backed Houthis have been attacking merchant shipping and US naval vessels in the Red Sea and firing drones and missiles at Israel since Hamas's October 7 attack. The group has issued new threats against Israeli targets, claiming responsibility for a failed attack on American warships in the Red Sea.
-Hurricane Helene has exposed a vulnerability in the semiconductor supply chain, as flooding at mines in North Carolina halted the production of ultra-pure quartz, which is vital to chip manufacturing. The storm, the most deadly to hit the US mainland since Hurricane Katrina in 2005, flooded the mountain town of Spruce Pine, which produces up to 90% of the world's ultra-pure quartz. This scarce mineral is used to make crucibles for high-grade silicon used in semiconductors. Any long-term interruption could affect downstream production of essential components in electronics, such as smartphones, computers, and solar panels. The hit comes as demand for servers for artificial intelligence outstrips supply of advanced chips. Vince Beiser, who visited Spruce Pine, said that there are no other sources of high-purity quartz with the same purity, quantity, and ease of access.
-After declaring their intention to privatize Aerolíneas Argentinas, the national airline of Argentina, the Milei government is escalating its anti-worker offensive by seeking to restrict the right to strike of aviation workers and pressing spurious criminal charges against Pablo Biro, General Secretary of the Asociación de Pilotos de Líneas Aéreas (APLA).
-Klarna Bank AB's board has decided to remove Mikael Walther, a confidant of co-founder Victor Jacobsson, amid ongoing disagreements at the Swedish buy-now, pay-later firm. The move will require shareholder approval. Klarna, founded in 2005 by Jacobsson and Sebastian Siemiatkowski, is preparing for a potential public offering next year. The company's strategy has been influenced by Walther. Klarna's revenue surged 27% in the first half of this year, with the company refocusing on artificial intelligence.
-Shein's senior executives are set to meet potential U.S. investors in the coming week as the fashion giant moves closer to a potential London listing. The Singapore-based company's founder and CEO, Sky Xu, will be the first to meet large institutional investors. Shein has faced increasing scrutiny from governments worldwide during its preparations for a potential stock listing. The company has moved to London after its plans for a multibillion-dollar listing in New York collapsed. Xu and Shein's chief financial officer, Leigh Gui, have started informal meetings with global investors in the UK.

NEW YORK TIMES
--The roots of Donald Trump's animus towards Ukraine can be traced back to a series of events between 2016 and 2017. In a meeting between President Vladimir V. Putin of Russia and former President Donald J. Trump in Hamburg in 2017, Putin disparaged Ukraine, a former Soviet republic with aspirations of joining the European Union and NATO. Putin argued that Ukraine was a corrupt, fabricated country and that Russia had every right to exert its influence over the country. Trump told Putin that his administration was considering giving weapons to Ukraine, to which Putin responded that it would be "a mistake" and that the Ukrainians would ask for more. This meeting highlights the political resentment and mistrust between the two leaders, as well as the potential consequences of Trump's re-election if he were elected again. The roots of Trump's animus towards Ukraine can be traced back to a series of events that spanned from 2016 to 2017.
-Hamas leader Yahya Sinwar is increasingly fatalistic and determined to see Israel embroiled in a wider regional conflict, according to US officials. Sinwar has long believed he will not survive the war, which has hindered negotiations to secure the release of hostages seized by his group in the October 7 attacks in Israel. His attitude has hardened in recent weeks, and American negotiators now believe that Hamas has no intention of reaching a deal with Israel. Prime Minister Benjamin Netanyahu of Israel has rejected proposals in the negotiations and added positions that have complicated the talks. US officials estimate that he is mainly concerned about his political survival and might not think a cease-fire in Gaza is in his interests. Hamas has shown no desire to engage in talks in recent weeks, and they suspect that Sinwar has grown more resigned as Israeli forces pursue him and talk about closing in on him. A larger war that puts pressure on Israel and its military would, in Sinwar's assessment, force them to scale back operations in Gaza.
-As the Israeli offensive in Lebanon expands to include ground incursions and intensifying airstrikes, senior Pentagon officials are discussing whether the enhanced U.S. military presence in the Middle East is helping to prevent a much wider war or emboldening Israel. In the 12 months since Hamas attacked Israel, launching a conflict that includes Yemen, Iran, and Lebanon, the Pentagon has sent a bristling array of weaponry to the region, including aircraft carriers, guided missile destroyers, amphibious assault ships, and fighter squadrons.
The Pentagon announced this week that it would add a "few thousand" more troops to the equation and essentially doubled its air power in the region. President Biden says the U.S. hardware and extra troops are there to help defend Israel and protect other American troops on bases throughout the region.
-The United States Central Command has conducted strikes against Houthi targets in Yemen, including "Houthi offensive military capabilities," in an effort to secure international waterways. The Iranian-backed Houthi militia in Yemen has been striking ships in the Red Sea in solidarity with Hamas since last year, disrupting commercial shipping. Central Command said on social media that it struck 15 targets in Houthi-controlled areas of Yemen. The attack on Sanaa came as the Houthis and their supporters were holding their weekly "million-man march" protest, which this week was focused on Israel's killing of Hezbollah leader Hassan Nasrallah in an airstrike near Beirut, Lebanon. Hashem Sharaf al-Din, a Houthi official, considered the strikes "a desperate attempt" to intimidate the Yemeni people and vowed not to be deterred by them.
-Conservative activists in Arizona and other states are accusing Latino advocacy groups of registering undocumented immigrants, leading to concerns about safety among canvassers. In Phoenix, four workers from a Latino nonprofit were filmed and yelled at while trying to register voters. The canvassers, who were wearing matching "Poder Latinx" T-shirts, were seen persuading reluctant Americans to register to vote. Conservative video blogger Vlad Stepanov, 33, noticed the suspicious appearance of the canvassers and asked if they were registering noncitizens to vote. The canvassers insisted they were following Arizona laws and registering only citizens. However, Stepanov argued that obtaining an ID does not prove a citizen. As the ground game intensifies ahead of state voter-registration deadlines in early October, suspicions of election fraud have turned the routine task of registering voters into tense confrontations.
-Kamala Harris has a unique connection to her estranged father, Donald J. Harris. Although the father has been mostly absent from Kamala’s life, he has played a significant role in shaping her into the person she is today. In her recent convention speech, Kamala Harris recalled a childhood memory of her father, who encouraged her to run and not let anything stop her. This moment seemed like a tribute to the bond between the father and daughter, but the reality is more complicated. Harris, an economist, lives with his second wife two miles from the vice president's official residence in Washington. Despite this, the two rarely speak, and Kamala Harris's convention speech was a rare instance where she publicly named her father, a stark contrast to her regular praise for her mother, Shyamala Gopalan Harris, a biomedical scientist who died in 2009.
-Vice President Kamala Harris campaigned in Michigan, a key battleground state, to strengthen her support among labor and the working class. At a rally in Flint, Michigan, she attacked former President Donald J. Trump as a threat to manufacturing jobs, while Gov. Gretchen Whitmer blamed him for the loss of 280,000 jobs in the state. Harris pledged to be a friend to organized labor, a day after the International Association of Fire Fighters declined to endorse a presidential candidate. The International Brotherhood of Teamsters also declined to weigh in on the race. Shawn Fain, the president of the powerful United Auto Workers union, was among the speakers at her rally.
-President Biden has urged Congress to provide emergency funding for the Small Business Administration (SBA) to help small-business owners recover from Hurricane Helene. In a letter to Congress leadership, Biden stated that the SBA's disaster relief program will run out of money in weeks before Congress reconvenes. He urged Congress to act to restore this funding. This comes just days after Republican Speaker Mike Johnson of Louisiana said he saw no need for Congress to return from its recess, which will continue through at least Election Day in early November. Johnson and other Republicans argue that the Federal Emergency Management Agency and other parts of the government have enough money in the short term and that it would take weeks to assess the longer-term needs of those in the path of the hurricane, which can be addressed after the election.
-A plan to place American-made reactors on a picturesque coastline in Poland has broad support in both Poland and Washington, but local opposition has run into geopolitical calculations. At a harvest festival in Choczewo, Poland, locals are bitterly divided on a proposed nuclear plant, Poland's first. The festival featured traditional folk songs, local farmers displaying their wares, and women in traditional dress singing folk songs. However, among the stalls selling sausages and hams was a more unusual sight: men in white lab coats discussing nuclear radiation, and protesters in T-shirts emblazoned with the message, "No Atoms on the Baltic!" The debate over nuclear energy is very real in Choczewo, a district in northern Poland dotted with farms, forests, and white-sand beaches.
-Former President Donald Trump and his allies, who often criticize undocumented immigrants, are targeting programs that allow millions of people to enter the United States lawfully. Trump has said he would again aim to curb legal channels into the country. However, remarks made by Trump and his running mate, Senator JD Vance of Ohio, signal that a second Trump administration would again aim to curb the legal channels that allow people to enter the country or obtain protection from deportation once inside its borders. In an interview with NewsNation, Trump said he would revoke a program that allows tens of thousands of Haitian immigrants to legally live in the country. This move signals a potential shift in the Trump administration's approach to immigration.
-The Biden administration has announced that it will allow temporary legal permission for migrants from Cuba, Venezuela, Haiti, and Nicaragua to lapse, forcing hundreds of thousands of people to find other methods to stay in the country or face deportation. This decision comes as political pressure mounts to cut down on programs that allow migrants to stay in the United States temporarily, even without a visa or green card. The Biden administration began a program allowing migrants from these four countries to apply to stay in the United States for two years, as long as they had a financial sponsor and passed background checks. The program was designed to discourage people from sneaking into the country by giving them a legal way to enter the United States. However, the administration now states that migrants cannot extend their stay under the program, according to an update on the Homeland Security Department's website.

NEW YORK POST
-Former New York Gov. David Paterson and his stepson were attacked by a trio of young suspects while walking their dog on the Upper East Side on Friday night. Paterson, 70, and his wife's 20-year-old son, Anthony Chester Sliwa, encountered the group of young men, possibly teens, climbing a fire escape on Second Avenue near East 96th Street shortly before 9 p.m. Paterson's spokesperson, Sean Darcy, confirmed that the group had a previous interaction with Paterson's stepson. Both Paterson and his stepson suffered some injuries but were able to fight off their attackers. The ex-governor, who is legally blind, sustained an injury to his head, while his stepson suffered a face wound. Sources said his stepson's injury was more severe. They were taken to NY-Presbyterian/Weill Cornell Medical Center as a precaution, and a police report had been filed. No arrests were made as of late Friday.
-Vice President Kamala Harris has resisted her previous support for banning gasoline-powered cars, stating that she will never tell Americans what car they have to drive. Harris made the remark during a campaign rally in Flint, Michigan, where she promised to retool existing factories and push policies that support innovation in advanced batteries and electric vehicles. The vice president's declaration is an apparent response to a Trump campaign ad running in Michigan, which claims, “Kamala Harris wants to end all gas-powered cars.” The ad continues, stating that Harris's push requiring electric-only is failing big and Michigan auto workers are paying the price.
-Toyota Motor Corp. is rethinking its approach to diversity and inclusion (DEI) and pro-LGBTQ events following a recent online controversy. The company has announced that it will limit community activities to align with STEM education and workforce readiness and will no longer participate in the Human Rights Campaign's Corporate Equality Index. This follows allegations by anti-woke activist Robby Starbuck that the company has funded groups opposing gender transition treatments on minors, formed Employee Resource Groups, and sponsored a drag queen program at a summer camp for kids. Toyota will continue to promote an inclusive environment, but will focus on activities that enhance business quality.

TechCrunch : Every fusion startup that has raised over $100M

Every fusion startup that has raised over $100M

Over the last several years, fusion power has gone from the butt of jokes — always a decade away! — to an increasingly tangible and tantalizing technology that has drawn investors off the sidelines.

The technology may be challenging to master and expensive to build today, but fusion promises to harness the nuclear reaction that powers the sun to generate nearly limitless energy here on Earth. If startups are able to complete commercially viable fusion power plants, then they have the potential to upend trillion-dollar markets.

The bullish wave buoying the fusion industry has been driven by three advances: more powerful computer chips, more sophisticated AI, and powerful high-temperature superconducting magnets. Together, they have helped deliver more sophisticated reactor designs, better simulations, and more complex control schemes.

It doesn’t hurt that, at the end of 2022, a U.S. Department of Energy lab announced that it had produced a controlled fusion reaction that produced more power than the lasers had imparted to the fuel pellet. The experiment had crossed what’s known as scientific breakeven, and while it’s still a long ways from commercial breakeven, where the reaction produces more than the entire facility consumes, it was a long-awaited step that proved the underlying science was sound.

Founders have built on that momentum in recent years, pushing the private fusion industry forward at a rapid pace. Fusion startups have raised $7.1 billion to date, according to the Fusion Industry Association, with the majority of it going to a handful of companies.

Commonwealth Fusion Systems
With a $1.8 billion Series B, Commonwealth Fusion Systems catapulted itself into the pole position in 2021. Since then, the company has been quiet on the fundraising front (no surprise), but it has been hard at work in Massachusetts building Sparc, its first-of-a-kind power plant intended to produce power at what it calls “commercially relevant” levels.

Sparc’s reactor uses a tokamak design, which resembles a doughnut. The D-shaped cross section is wound with high-temperature superconducting tape, which when energized, generates a powerful magnetic field that will contain and compress the superheated plasma. In Sparc’s successor, the commercial-scale Arc, heat generated from the reaction is converted to steam to power a turbine. CFS designed its magnets in collaboration with MIT, where co-founder and CEO Bob Mumgaard worked as a researcher on fusion reactor designs and high-temperature superconductors.

Backed by Breakthrough Energy Ventures, The Engine, Bill Gates, and others, Devens, Massachusetts-based CFS expects to have Arc operational in the early 2030s.

General Fusion
Now in its third-decade, General Fusion has raised $440.53 million, according to PitchBook. The company, based in Richmond, British Columbia, was founded in 2002 by physicist Michel Laberge, who wanted to prove a different approach to fusion known as magnetized target fusion (MTF).

In General Fusion’s reactor, a liquid metal wall surrounds a chamber in which plasma is injected. Pistons surrounding the wall push it inward, compressing the plasma inside and sparking a fusion reaction. The resulting neutrons heat the liquid metal, which can be circulated through a heat exchanger to generate steam to spin a turbine.

The company is currently building its first demonstration plant, LM26, which it hopes will hit scientific breakeven by 2026. Investors include Jeff Bezos, Temasek, BDC Capital, and Chrysalix Venture Capital.

Helion
Of all fusion startups, Helion has the most aggressive timeline. The company plans to produce electricity from its reactor in 2028. Its first customer? Microsoft.

Helion uses a type of reactor called a field-reversed configuration, where magnets surround a reaction chamber that looks like an hourglass with a bulge at the point where the two sides come together. At each end of the hourglass, they spin the plasma into doughnut shapes that are shot toward each other at more than 1 million mph. When they collide in the middle, additional magnets help induce fusion. When fusion occurs, it boosts the plasma’s own magnetic field, which induces an electrical current inside the reactor’s magnetic coils. That electricity is then harvested directly from the machine.

Based in Everett, Washington, Helion has raised $607.64 million, according to PitchBook. Investors include Sam Altman, Reid Hoffman, KKR, BlackRock, Peter Thiel’s Mithril Capital Management, and Capricorn Investment Group.

TAE
Founded in 1998, TAE (formerly known as Tri Alpha Energy) was spun out of the University of California, Irvine by Norman Rostoker. It uses a field-reversed configuration, but with a twist: After the two plasma shots collide in the middle of the reactor, the company bombards the plasma with particle beams to keep it spinning in a cigar shape. That improves the stability of the plasma, allowing more time for fusion to occur and for more heat to be extracted to spin a turbine.

TAE has raised $1.32 billion, according to PitchBook. Investors include Alphabet, Chevron Technology Ventures, and Venrock.

Zap Energy
Zap Energy isn’t using high-temperature superconducting magnets or super-powerful lasers to keep its plasma confined. Rather, it zaps the plasma (get it?) with an electric current, which then generates its own magnetic field. The magnetic field compresses the plasma about 1 millimeter, at which point ignition occurs. The neutrons released by the fusion reaction bombard a liquid metal blanket that surrounds the reactor, heating it up. The liquid metal is then cycled through a heat exchanger, where it produces steam to drive a turbine.

Like Helion, Zap Energy is based in Everett, Washington, and the company has raised $327 million, according to PitchBook. Backers include Bill Gates’ Breakthrough Energy Ventures, DCVC, Lowercarbon, Energy Impact Partners, Chevron Technology Ventures, and Bill Gates as an angel.

Tokamak Energy
Tokamak Energy takes the usual tokamak design — the doughnut shape — and squishes it, reducing its aspect ratio to the point where the outer bounds start resembling a sphere. Like many other tokamak-based startups, the company uses high-temperature superconducting magnets (of the rare earth barium copper oxide, or REBCO, variety). Since its design is more compact than a traditional tokamak, it requires less in the way of magnets, which should reduce costs.

The Oxfordshire, U.K.-based startup’s ST40 prototype, which looks like a large, steampunk Fabergé egg, generated an ultra-hot, 100 million degree C plasma in 2022. Its next generation, Demo 4, is currently under construction and is intended to test the company’s magnets in “fusion power plant-relevant scenarios.” Tokamak Energy has raised $285.65 million from investors including Future Planet Capital, In-Q-Tel, Midven, and Capri-Sun founder Hans-Peter Wild, according to PitchBook.

First Light
Unlike many other fusion startups, First Light doesn’t use magnets to generate the conditions necessary for fusion. Instead, it follows an approach known as inertial confinement, in which fusion fuel pellets are compressed until they ignite.

But even then, First Light doesn’t hew to orthodoxy. Most attempts at inertial confinement use lasers to do the dirty work, following the lead of the National Ignition Facility, which produced a groundbreaking experiment in 2022. Rather, First Light fires a projectile at a target using a two-stage gun; the first stage uses gunpowder to fire a plastic piston that compresses hydrogen to 145,000 psi, which then launches the projectile. The target is designed to amplify the force of the impact so it compresses the fuel to the point of ignition.

Based in Oxfordshire, U.K., First Light has raised $179.94 million from investors including Invesco, IP Group, and Tencent.

Marvel Fusion
Marvel Fusion follows the inertial confinement approach, the same basic technique that the National Ignition Facility used to prove that controlled nuclear fusion reactions could produce more power than was needed to kick them off. Marvel fires powerful lasers at a target embedded with silicon nanostructures that cascade under the bombardment, compressing the fuel to the point of ignition. Because the target is made using silicon, it should be relatively simple to manufacture, leaning on the semiconductor manufacturing industry’s decades of experience.

The inertial confinement fusion startup is building a demonstration facility in collaboration with Colorado State University, which it expects to have operational by 2027. Munich-based Marvel has raised a total of $109.3 million from investors including b2venture, Deutsche Telekom, Earlybird, HV Capital, and Taavet Hinrikus and Albert Wenger as angels.

Xcimer
Though nothing about fusion can be described as simple, Xcimer takes a relatively straightforward approach: follow the basic science that’s behind the National Ignition Facility’s breakthrough net-positive experiment, and redesign the technology that underpins it from the ground up. The Colorado-based startup is aiming for a 10-megajoule laser system, five times more powerful than NIF’s setup that made history. Molten salt walls surround the reaction chamber, absorbing heat and protecting the first solid wall from damage.

Founded in January 2022, Xcimer has already raised $109 million, according to PitchBook, from investors including Hedosophia, Breakthrough Energy Ventures, Emerson Collective, Gigascale Capital, and Lowercarbon Capital.

CrunchBase' : North American Startup Funding Weakened In Q3 As Largest Deal Took

North American Startup Funding Weakened In Q3 As Largest Deal Took Longer To Close

The past quarter was a quirky one for North America startup funding, with a slowdown in some pockets counterbalanced by continued high enthusiasm around artificial intelligence, Crunchbase data shows.

Overall, the number and size of funding rounds to North American startups slowed sequentially in the third quarter based on reported investments. However, the tallies did not include an enormous $6.6 billion financing for OpenAI that was widely reported in Q3 but only officially announced this week.

In total, investors put $40.5 billion into startups across all stages in Q3. That’s a decline of 10% from the prior quarter and an increase of 22% from year-ago levels. Late-stage dealmaking showed the largest gains, while early-stage funding posted the steepest sequential decline.

For perspective, we charted investment totals, color-coded by stage, for the past 11 quarters below.

Investments were also spread across fewer deals. Known round counts across all stages totaled around 2,065 for the quarter — down both sequentially and year over year.

CrunchBase : The Week’s 10 Biggest Funding Rounds: OpenAI On Top — By A Lot

The Week’s 10 Biggest Funding Rounds: OpenAI On Top — By A Lot

It is no shock to see the company that tops this list — a $6.6 billion raise makes a lot of headlines. However, it was far from the only big round this week, as seven of them topped $100 million — including $500 million for yet another AI company.

1. OpenAI, $6.6B, artificial intelligence: OpenAI announced its long-awaited raise of $6.6 billion at a post-money valuation of $157 billion led by Thrive Capital. The new round makes the ChatGPT creator one of the most valuable private companies in the world and also included investment from the likes of Altimeter Capital, Fidelity, Khosla Ventures, Microsoft, Nvidia, SoftBank and Abu Dhabi-based MGX. Just this week it was reported SoftBank’s Vision Fund would invest $500 million in the round. The new round comes just as the company is facing myriad issues, including an exodus of higher-up employees and a restructuring change to switch it from a nonprofit to a for-profit benefit corporation and to give co-founder Sam Altman equity in the company. The funding structure seems to take those factors into account, as it came in the form of convertible notes and reportedly allows for investors to ask for their money back if the change is not completed within two years and removes the cap on returns for investors. The new round is bigger than the $6 billion round Elon Musk’s generative AI startup, xAI, officially announced in May — which was the largest round raised this year.

2. Poolside, $500M, artificial intelligence: Most weeks a half-billion-dollar round would top this list — but this isn’t most weeks. Poolside closed a $500 million Series B led by Bain Capital Ventures. The new round values the startup at $3 billion, Bloomberg reported. The startup builds artificial intelligence software for programmers. Poolside is just one of a handful of big deals recently in the AI coding space. In August, San Francisco-based Magic, which also develops AI models to write software, raised a $320 million round, and AI-powered coding assistant Codeium closed a $150 million Series C. Poolside has raised $626 million since being founded in May 2023.

3. Kailera Therapeutics, $400M, biotech: Biotech was even bigger this week than normal. Case in point — Kailera Therapeutics’ massive raise. The Boston-based biotech announced its launch this week with a $400 million Series A financing co-led by Atlas Venture, Bain Capital Life Sciences and RTW Investments. The new company is developing several clinical-stage injectable and oral therapies to help with chronic weight management.

4. Aktis Oncology, $175M, biotech: Boston-based Aktis Oncology, a clinical-stage biotech startup developing novel targeted alpha radiopharmaceuticals to treat a broad range of solid tumors, closed a $175 million Series B led by Janus Henderson Investors, RA Capital Management and RTW Investments. In 2022, the company closed an $84 million extension round partially funded by large pharma companies such as Merck, Bristol Myers Squibb and Novartis, after raising a $72 million Series A round in 2021. Founded in 2021, the company has raised $331 million, per Crunchbase.

5. Impulse Space, $150M, space: Space tech seems to be having a moment again right now. Impulse locked up a $150 million Series B led by Founders Fund. The Redondo Beach, California-based space startup is developing a line of orbital transfer vehicles — also called “space tugs” — which serve as a last-mile cargo delivery service once payloads get into orbit. Founded in 2021, the company has raised $225 million, per Crunchbase.

6. (tied) Nusano, $115M, healthcare: Valencia, California-based Nusano, a physics startup developing radioisotopes for medical and industrial uses, announced a $115 million-plus Series C led by the Wasatch Group. Founded in 2013, this is the company’s first round of a disclosed amount, per Crunchbase.

6. (tied) Triveni Bio, $115M, biotech: Triveni Bio, a Watertown, Massachusetts-based biotech startup developing antibody treatments for immunological and inflammatory disorders, locked up a $115 million Series B led by Goldman Sachs Alternatives. Founded in 2019, the company has raised $207 million, per Crunchbase.

8. Eon, $77M, cloud management: New York-based Eon, a cloud backup startup, launched from stealth and announced a $77 million Series B led by Greenoaks. The company also announced it has raised a total of $127 million in funding.

9. Crescendo, $50M, artificial intelligence: Crescendo, a developer of an augmented-AI customer experience platform, closed a series of venture round financings totaling $50 million. The last was led by General Catalyst and valued the San Francisco-based company at $500 million post this investment.

10. (tied) DataPelago, $47M, data: Mountain View, California-based DataPelago, which offers data analytic tools, launched from stealth with $47 million in funding from several investors.

10. (tied) Nym, $47M, productivity: Nym, a New York-based autonomous medical coding startup, raised a $47 million growth investment led by PSG Equity. Founded in 2018, the company has raised nearly $95 million, per Crunchbase.

Big global deals
The biggest deal of the week outside the U.S. came from across the pond.
  • London-based Newcleo, an atomic energy company focused on developing advanced nuclear energy technologies, raised nearly $148 million in a Series A.

WSJ : Rock-Star Law Firms Are Billing Up to $2,500 per Hour. Clients Are Indigna

Rock-Star Law Firms Are Billing Up to $2,500 per Hour. Clients Are Indignant.
Companies complain about rising legal bills. ‘It’s not sustainable,’ says one general counsel.

Big companies around the world are pushing back against rapidly rising legal bills, railing against hourly lawyer rates they say are the product of law-firm excess.

Lawyers’ hourly rates rose almost 9% in the first half of 2024, according to data from Wells Fargo legal specialty group, which surveys large law firms quarterly. That’s on top of an 8.3% increase in rates last year. Historically, fees would rise about 4% each year, Wells Fargo says.

Lawyers’ pay is skyrocketing. Brutal poaching wars for talent are now common, and top lawyers expect to be paid like investment bankers and private-equity principals.

“You don’t negotiate with those guys. You aren’t going to bet the company,” said Matthew Lepore, general counsel for chemical giant BASF. “Clients aren’t doing as well as the law firms are doing, and it’s not sustainable.”

In certain specialties, such as merger counseling, regulatory compliance, tax and private equity, corporate general counsels say there is only a small pool of firms to choose from. Companies venturing into high-stakes deals turn to the most elite firms, with the hopes that the high price tag promises the best outcomes. Hourly rates can run $2,500 or more for the most sought-after attorneys, and are expected to keep rising, according to legal recruiters and court filings.

“The market is driven by the top end. The top firms are spending money to compete for the best rock-star talent. That’s what is driving this,” said Alan Tse, chief legal officer at global commercial real-estate firm JLL. “Obviously not enough of us are saying no. Clients are part of the problem.”

Paid more than bankers
The top law firms have grown in size and seen their revenues shoot upward as they’ve become one-stop shops for corporate clients for deal work, litigation, and tax advice. The legal industry has shifted its compensation structure, and only a few firms still have a classic lockstep pay system that rewards based on seniority. Instead, firms pay up for stars and based on productivity. The flexibility increases the cost of talent.

Law firm revenue growth was up 11.4% in the first six months of 2024, outpacing expenses, according to a Citi Global survey of top law firms.

Superstar attorney hires can command salaries of as much as $15 million to $20 million a year, eclipsing even the Wall Street bankers, lawyers, consultants, and legal recruiters say. Beyond that rarefied level, many lawyers have seen their pay double in recent years. At the lower end of attorney pay, junior associates at large law firms can start at $250,000 a year. That’s about a 30% jump in five years from the starting salary of $190,000 in 2018.

Law firms traditionally charge companies by billing rates per hour, and the firm will be hired for a project or issue and then charges based on how much time it spends on the project. Inside the firms, associates and partners are often judged based on the billable hours they produce, as well as the outcome for the client.

To bring down legal costs, companies are pitting firms against each other for more competitive bids and moving work in-house to their own legal departments.

At beer maker Heineken, general counsel Ernst van de Weert has moved some legal work away from large firms to smaller boutiques.

“You can get the same kind of quality for half the rate,” he said. “You have more choices than you realize.”

Indeed, rates are increasing fastest at the top firms. Fees at the top 50 law firms rose 10% in the first half of the year, compared with about 7% for the next tiers, ranked 51 to 100, and 100 to 200, according to Wells Fargo.

Lawyers at the nation’s largest firms billed between $500 to more than $1,300 per hour for litigation in 2023, according to the National Association of Legal Fee Analysis. It can be higher in other markets.

In New York City, mergers and acquisitions are the most expensive area and many top-ranking firms have partner rates that exceed $2,000 an hour, and can be as high as $1,000 for associates, according to Persuit, a software company that in-house counsel uses to control hourly rates.

It’s increasingly a bifurcated market, with the top firms with large corporate practices such as Wachtell Lipton; Kirkland Ellis; Paul Weiss; Davis Polk, and Simpson Thacher moving away from the pack. Several of the largest firms have poached entire practice groups from each other, luring recruits with significant boosts in pay. But at the same time, the work of some of this rarefied talent can draw tens of millions to hundreds of million in revenue for the firms.

“The game is to get as many stars as you can because it helps to lock in business,” Paul Weiss chairman Brad Karp said.

Fighting billable hours
Companies are increasingly pushing alternative fee arrangements. They’ll cap the fees, fix rates to avoid runaway costs, or make a deal to give the firm an incentive to win with a “success bonus” guarantee. They’ll put out bids for work and have firms present their best offers that include proposals to keep costs somewhat at bay.

Some clients are trying to keep down their own hourly costs by being thoughtful in how they use outside firms. “It’s all too easy to go to speed dial, ‘Bob, help!’ Then the clock starts before the phone is put down. As a client, you have to be more disciplined,” said Ashley John, head of legal operations at British mining conglomerate Anglo American. The company, owner of diamond retailer DeBeers, works with 15 to 20 law firms around the globe.

Frank Ryan, global co-chair at DLA Piper, one of the top law firms, said the world has become more complicated for businesses. He pointed to the explosion of private equity in the last decade, which has been a boon for firms who represent financial firms and advise them on multibillion-dollar mergers. This creates work on both sides of a deal for law firms. He also said the aggressive regulatory environment and complex intellectual property matters create more opportunities for specialized legal work.

“There are some firms that are always in a general counsel’s Rolodex, there’s no question,” Ryan said. “The world has gotten smaller in a way, but that creates more opportunity for law firms.”

Advancements in generative artificial intelligence could change the economics of law firms, with many firms testing the tools to handle work such as summarizing legal filings that is the purview of junior associates. AI should lower costs and increase efficiency, legal department heads said.

Shell sent a letter in June to outside firms the energy giant was considering hiring. Its work wasn’t guaranteed, “as we constantly test the market for efficiency and cost effectiveness,” according to a copy of the letter from legal director Philippa Bounds reviewed by The Wall Street Journal. It asked the firms to explain how they are using generative AI tools, saying that the firms “that develop into that fertile ground” and are clear about how they are using it will have a competitive advantage.

Shell tries to avoid the hourly rate model in general, arguing it provides little incentive for attorneys to work quickly. Shell’s head of legal operations, Gordon McCue, has pushed firms to use alternative fee arrangements so that Shell has a predictable and transparent rate in the final legal bill.

“There could be a tendency, conscious or unconscious, to not want to be that much more efficient because the hourly rates are massive,” McCue said.

“This doesn’t solve the problem,” McCue said. “It’s up to the companies to push for change.”