WSJ : Ozempic Among the Next Drugs Up for Medicare Price Negotiations

Ozempic Among the Next Drugs Up for Medicare Price Negotiations
List of drugs account for $41 billion in annual Medicare spending, Biden administration says

The U.S. government named 15 drugs that will be subject to the second round of price negotiations by Medicare, including Ozempic and Wegovy, the drugs at the center of the weight-loss craze.

The Biden administration said the drugs account for $41 billion in annual Medicare spending, and that price negotiations could result in significant savings. U.S. health officials selected the drugs because they account for high Medicare spending due to widespread use or high price tags.

“We have a chance to negotiate a better deal for the American people,” said U.S. Secretary of Health and Human Services Xavier Becerra. “We can try to save them once again billions of dollars.”

On the list of target medicines are treatments for cancer, type 2 diabetes, and asthma.

The government last year negotiated lower prices for the first 10 drugs selected for the new negotiating powers Medicare received from the Inflation Reduction Act of 2022. Those prices will take effect next year in Medicare, the government health insurance program for the elderly and some disabled people. Biden touted $6 billion in savings for taxpayers this year from those negotiations in his farewell letter Wednesday.

The hottest drug on the list is Novo Nordisk’s semaglutide, sold under the brands Ozempic and Wegovy and at the heart of the weight-loss boom that has made Novo NOVO.B -2.59%decrease; red down pointing triangle a fortune.

Semaglutide likely accounted for about $7.5 billion in gross spending by Medicare drug-benefit plans in 2023, according to research in the Journal of Managed Care & Specialty Pharmacy, by health-policy researchers from the University of Washington and the University of California, San Diego. The drug’s global sales were estimated to be about $28 billion last year, according to Factset.

A steep price cut for semaglutide in Medicare could dent Novo’s sales growth modestly, though analysts still expect semaglutide’s global sales to double over the next four years.

A price cut, however, could save Medicare and its members billions of dollars.

“There’s going to be pretty significant savings to Medicare,” said Sean Sullivan, a professor of pharmacy and health policy researcher at the University of Washington.

A price cut for semaglutide in Medicare could also have spillover effects, pressuring prices for Eli Lilly’s LLY 1.45%increase; green up pointing triangle Mounjaro diabetes drug and Zepbound for weight loss, Sullivan said.

Semaglutide is sold as Ozempic and Rybelsus for diabetes, and Wegovy for obesity. All three brands will be treated as a single drug for Medicare price negotiations purposes because they share the same main ingredient.

Ozempic accounts for most of the Medicare spending on semaglutide, but Wegovy is poised for higher spending. Last year, some Medicare drug plans began covering Wegovy for people with both excess weight and cardiovascular disease. The Biden administration proposed expanding Medicare coverage to include its use in people with obesity alone, though that hasn’t taken effect and its fate is uncertain under the incoming Trump administration.

If Medicare were to cover anti-obesity drugs, it would increase federal spending by about $35 billion from 2026 to 2034, the Congressional Budget Office estimated last year. The CBO predicted semaglutide would be selected for negotiation and that its price would fall substantially beginning in 2027.

Semaglutide sells for list prices ranging from $997 a month for Ozempic and Rybelsus to $1,349 a month for Wegovy.

Federal negotiators will be seeking a much lower price. Already, Novo Nordisk offers rebates and discounts that have cut roughly 50% or more off list prices, analysts say.

As a result, U.S. government negotiators are expected to use those existing net prices as a ceiling for their offers, to seek further cuts that go beyond 50% off the list price.

>>> Novo Nordisk A/S announced headline results from STEP UP; Semaglutide 7.2 mg

Novo Nordisk A/S announced headline results from STEP UP; Semaglutide 7.2 mg s.c. achieved 20.7% weight loss in the STEP UP obesity trial, and 18.7% regardless of treatment adherence
  • STEP UP is a 72-week efficacy and safety trial investigating subcutaneous semaglutide 7.2 mg compared to semaglutide 2.4 mg and placebo, all administered once weekly. The trial included 1,407 randomised adults with obesity. All treatment arms were in conjunction with lifestyle intervention.
  • The trial achieved its primary endpoint by demonstrating a statistically significant and superior weight loss at week 72 with semaglutide 7.2 mg versus placebo. When evaluating the effects of treatment if all people adhered to treatment from a mean baseline body weight of 113 kg, people treated with semaglutide 7.2 mg achieved a superior weight loss of 20.7% after 72 weeks compared to a reduction of 17.5% with semaglutide 2.4 mg and 2.4% with placebo. In addition, 33.2% of those who received semaglutide 7.2 mg achieved a weight loss of 25% or more after 72 weeks, compared to 16.7% with semaglutide 2.4 mg and 0.0% with placebo. When applying the treatment policy estimand2, people treated with semaglutide 7.2 mg achieved a superior weight loss of 18.7% compared to a reduction of 15.6% with semaglutide 2.4 mg and 3.9% with placebo. In the trial, semaglutide 7.2 mg appeared to have a safe and well-tolerated profile.
  • The most common adverse events were gastrointestinal, and the vast majority were mild to moderate and diminished over time, consistent with the GLP-1 receptor agonist class.
  • The results from the second semaglutide 7.2 mg phase 3 trial, STEP UP T2D, in adults with type 2 diabetes and obesity are expected within the next few months.

>>> US Gapping down

Gapping down
In reaction to earnings/guidance
:
  • JBHT -9.8%, FAST -5.2%, WAFD -3.2%, CFG -2.6%, EYE -2.2%, CECO -2%, PNNT -1.7%, STT -1.1%
Other news:
  • ABL -17.2% (stock offering)
  • FIGS -3.3% (not pursuing STORY3's acquisition proposal)
  • CSTL -2.5% (Poster on DecisionDx-SCC selected as a "late breakers" top five finalist for the akamai award, recognizing the best posters at Maui Derm Hawaii 2025)
  • ED -2% (increases dividend)
  • NVO -1.7% (announced headline results from STEP UP; Semaglutide 7.2 mg s.c. achieved 20.7% weight loss in the STEP UP obesity trial, and 18.7% regardless of treatment adherence)
  • BAM -0.7% (CEO taking on additional role of Chair)
  • ESEA -0.7% (sale of its containership)

>>> US Gapping up

Gapping up
In reaction to earnings/guidance
:
  • TFC +2.9%, SLB +2.2%, OZK +1.5%, HBAN +1.5%, WDC +0.9%, WIT +0.9%
Other news:
  • AUTL +5.4% (presents clinical data updates at the 2025 tandem meetings)
  • WULF +4.1% (mixed shelf)
  • AEVA +3.2% (transfering listing to Nasdaq)
  • BKSY +2.8% (selected for $200 mln contract)
  • CXW +2.1% (expands Montana relationship)
  • RIVN +2% (loan agreement with DOE for up to $6.6 bln)
  • PLUG +1.8% (loan guarantee of $1.66 bln from DOE)
  • ICL +1.6% (JV with Shenzhen Dynanonic Co.)
  • MWA +1.5% (appoints new CFO)
  • GEO +1.3% (comments on U.S. Court of Appeals ruling)
  • RC +0.9% (authorizes $150 mln repurchase plan)
  • OTIS +0.9% (authorizes $2 bln repurchase plan)
  • LYFT +0.9% (wins dismissal of shareholder lawsuit, according to Bloomberg)
  • TLX +0.9% (Illuccix receives European approval)
  • TRGP +0.9% (to propose dividend raise in Q1)

>>> US Research Calls I

Research Calls I
  • Upgrades:
    • American Airlines (AAL) upgraded to Neutral from Underperform at BofA Securities; tgt raised to $20
    • Applied Materials (AMAT) upgraded to Overweight from Sector Weight at KeyBanc Capital Markets; tgt $225
    • AT&T (T) upgraded to Neutral from Sell at Arete
    • Axalta Coating Systems (AXTA) upgraded to Outperform from Peer Perform at Wolfe Research; tgt $41
    • Clearwater Analytics (CWAN) upgraded to Overweight from Equal-Weight at Morgan Stanley; tgt raised to $34
    • Cloudflare (NET) upgraded to Buy from Neutral at Citigroup; tgt raised to $145
    • DuPont (DD) upgraded to Outperform from Peer Perform at Wolfe Research; tgt $91
    • Enersys (ENS) upgraded to Outperform from Perform at Oppenheimer; tgt $115
    • Lam Research (LRCX) upgraded to Overweight from Sector Weight at KeyBanc Capital Markets; tgt $95
    • Life360 (LIF) upgraded to Buy from Neutral at UBS; tgt raised to $55
    • Lumentum (LITE) upgraded to Overweight from Underweight at Barclays; tgt raised to $125
    • MoonLake Immunotherapeutics (MLTX) upgraded to Buy from Neutral at Goldman; tgt raised to $82
    • Salesforce (CRM) upgraded to Buy from Hold at TD Cowen; tgt raised to $400
    • SAP SE (SAP) upgraded to Buy from Hold at TD Cowen; tgt raised to $305
    • Ultrapar Participacoes (UGP) upgraded to Buy from Hold at HSBC Securities
    • Ventas (VTR) upgraded to Outperform from Neutral at Robert W. Baird; tgt lowered to $65
  • Downgrades:
    • AmBev (ABEV) downgraded to Neutral from Buy at BofA Securities
    • Avantor (AVTR) downgraded to Neutral from Buy at UBS; tgt lowered to $25
    • Charles River (CRL) downgraded to Neutral from Buy at UBS; tgt lowered to $185
    • H&E Equipment (HEES) downgraded to Neutral from Buy at UBS; tgt raised to $92
    • HubSpot (HUBS) downgraded to Hold from Buy at TD Cowen; tgt raised to $725
    • JetBlue Airways (JBLU) downgraded to Underperform from Neutral at BofA Securities; tgt $6.50
    • Lucky Strike Entertainment (LUCK) downgraded to Neutral from Overweight at JP Morgan; tgt lowered to $12
    • Rapid7 (RPD) downgraded to Hold from Buy at Stifel; tgt lowered to $42
    • Southwest Air (LUV) downgraded to Underperform from Neutral at BofA Securities; tgt $31
    • Spotify (SPOT) downgraded to Peer Perform from Outperform at Wolfe Research
    • Tenable (TENB) downgraded to Hold from Buy at Stifel; tgt lowered to $45
    • Tenaris (TS) downgraded to Hold from Buy at Kepler
    • Warby Parker (WRBY) downgraded to In-line from Outperform at Evercore ISI; tgt $23
  • Others:
    • Atlassian (TEAM) initiated with a Neutral at Cantor Fitzgerald; tgt $264
    • Builders FirstSource (BLDR) initiated with an Outperform at Raymond James; tgt $180
    • Cloudflare (NET) initiated with a Neutral at Cantor Fitzgerald; tgt $111
    • Commvault Systems (CVLT) initiated with a Neutral at Cantor Fitzgerald; tgt $159
    • ConocoPhillips (COP) initiated with a Buy at TD Cowen; tgt $125
    • Crocs (CROX) downgraded to Hold from Buy at Williams Trading
    • Datadog (DDOG) initiated with an Overweight at Cantor Fitzgerald; tgt $180
    • DigitalOcean (DOCN) initiated with a Neutral at Cantor Fitzgerald; tgt $39
    • Dynatrace (DT) initiated with a Neutral at Cantor Fitzgerald; tgt $58
    • Elastic (ESTC) initiated with a Neutral at Cantor Fitzgerald; tgt $108
    • Expand Energy Corporation (EXE) initiated with a Hold at TD Cowen; tgt $108
    • Five9 (FIVN) initiated with an Overweight at Cantor Fitzgerald; tgt $46
    • Flutter Entertainment (FLUT) initiated with a Buy at Stifel; tgt $320
    • Informatica (INFA) initiated with a Neutral at Cantor Fitzgerald; tgt $29
    • Microsoft (MSFT) initiated with an Overweight at Cantor Fitzgerald; tgt $509
    • Monday.com (MNDY) initiated with an Overweight at Cantor Fitzgerald; tgt $292
    • MongoDB (MDB) initiated with an Overweight at Cantor Fitzgerald; tgt $344
    • NICE (NICE) initiated with a Neutral at Cantor Fitzgerald; tgt $176
    • Oracle (ORCL) initiated with an Overweight at Cantor Fitzgerald; tgt $214
    • Orion Group (ORN) initiated with a Buy at DA Davidson; tgt $11
    • Palantir Technologies (PLTR) initiated with a Neutral at Cantor Fitzgerald; tgt $72
    • Semtech (SMTC) initiated with a Buy at UBS; tgt $85
    • ServiceNow (NOW) initiated with an Overweight at Cantor Fitzgerald; tgt $1332
    • Snowflake (SNOW) initiated with an Overweight at Cantor Fitzgerald; tgt $201
    • Sterling Infrastructure (STRL) initiated with an Outperform at William Blair
    • Watsco (WSO) initiated with a Mkt Perform at Raymond James
    • Zoom Communications (ZM) initiated with a Neutral at Cantor Fitzgerald; tgt $87

>>> Europe : Brokers Upgrades & Downgrades - 17th of January 2025 V3(++)

>>> Up
* Addnode Group AB Raised to Buy at Kepler Cheuvreux (+)
* Applied Materials Raised to Overweight at KeyBanc; PT $225
* Atrium Ljungberg Raised to Hold at Nordea
* Azelis Raised to Buy at UBS (+)
* Brenntag Raised to Equal-Weight at Barclays; PT 70 euros
* DNO Raised to Buy at Arctic Securities; PT 14 kroner (++)
* Duell Raised to Buy at Inderes; PT 9 euros
* Duell Raised to Buy at SEB Equities; PT 9 euros
* Epiroc Raised to Neutral at Oddo BHF; PT 195 kronor
* Great Portland Raised to Neutral at UBS (+)
* IMCD Raised to Overweight at Barclays; PT 187 euros
* Kesko Raised to Accumulate at OP Corporate Bank; PT 19.50 euros (++)
* M&C Saatchi Raised to Buy at Peel Hunt; PT 210 pence (+)
* Maire Raised to Buy at Kepler Cheuvreux (+)
* Orsted Raised to Buy at ABG; PT 400 kroner
* Salesforce Inc Raised to Buy at TD Cowen; PT $400
* SAP ADRs Raised to Buy at TD Cowen; PT $305
* Swedbank Cut to Market Perform at Handelsbanken; PT 322 kronor (++)
* Taylor Wimpey Raised to Add at Peel Hunt; PT 130 pence (+)
* TSMC ADRs PT Raised to $270 from $240 at Argus
* Virbac Raised to Buy at CIC; PT 400 euros (+)

>>> Down
* Argan Cut to Hold at Bank Degroof Petercam; PT 72 euros (++)
* Avolta Soars; Buyback a Further Signal of Stability, ZKB Says (++)
* Brenntag Cut to Neutral at UBS (+)
* Dormakaba Cut to Neutral at Oddo BHF; PT 691 Swiss francs
* Evolution Cut to Sell at Redburn; PT 720 kronor
* HubSpot Cut to Hold at TD Cowen; PT $725
* Mon Courtier Energie Groupe Cut to Hold at TP ICAP Midcap (++)
* Netcompany Cut to Hold at Jyske Bank; PT 375 kroner (+)
* Richemont Cut to Neutral at CIC; PT 160 Swiss francs (+)
* Saipem Cut to Hold at Kepler Cheuvreux; PT 3 euros (++)
* SSAB Cut to Accumulate at OP Corporate Bank; PT 59 kronor (++)
* Sunrise Communications Re-Initiated Buy at Bank Vontobel (+)
* Tenaris Cut to Hold at Kepler Cheuvreux (+)
* Trustpilot Cut to Sell at Panmure Liberum; PT 245 pence (+)
* Wise Cut to Add at Peel Hunt; PT 1,100 pence
* Virbac Cut to Neutral at Oddo BHF; PT 365 euros (++)
* Vivendi Cut to Hold at HSBC; PT 2.70 euros

>>> Initiation
* Baader Rated New Buy at DZ Bank; PT 4.80 euros
* Hermes Reinstated Buy at William O'Neil (++)
* Hexagon Purus Rated New Buy at Pareto Securities; PT 7 kroner
* Hexagon Composites Reinstated Buy at Pareto Securities
* HUTCHMED China Rated New Buy at UOB Kay Hian; PT 314.78 pence
* IG Design Cut to Hold at Panmure Liberum; PT 60 pence (+)
* Microsoft Rated New Overweight at Cantor; PT $509
* Oracle Reinstated Overweight at Cantor; PT $214
* Palantir Rated New Neutral at Cantor; PT $72
* Snowflake Rated New Overweight at Cantor; PT $201
* Sveafastigheter Rated New Buy at Arctic Securities; PT 51 kronor
* Vaisala Raised to Buy at Evli Bank; PT 56 euros


>>> Call
* Orsted Gains as ABG Lifts, Cites Risk Reward Turning Positive (++)
* Sanofi Shares Rise; Berenberg Calls Valuation Highly Attractive (++)
* SAP Raised as TD Cowen Sees Better Growth, Margins Through 2027 (++)
* Goldman Strategists Say Europe Large-Cap Stocks Worth Revisiting (++)
* European Pharma, Life Sciences Sector Cut to Neutral at Barclays (+)
* Trump Policy Risk Weighs on European Stocks, Barcays’ Cau Says (+)

FT : Octopus overtakes British Gas as Britain’s largest residential energy suppl

Octopus overtakes British Gas as Britain’s largest residential energy supplier
Energy company has 12.9mn domestic electricity and gas accounts, giving it 24% market share

Octopus Energy has overtaken British Gas to become Britain’s largest residential energy supplier by meters on supply, capping a big market shift over the past 10 years as challengers have ousted the so-called Big Six.

Launched in London in 2016, Octopus now has 12.9mn British domestic electricity and gas accounts, as measured by energy meters, according to a market share survey by Cornwall Insight.

The figure is 320,000 more than British Gas, which has been the largest supplier since the British market opened to competition at the end of the 1990s, and gives Octopus a market share of about 24 per cent.

Dan Morris, chief executive of Cornwall Insight, which published the figures on Friday, said it marked the “biggest development in the domestic retail energy market since it opened”. 

The rapid rise of Octopus was a “notable achievement in the highly competitive and tightly regulated UK supplier market”, he added.  

Most households have two energy meters, one for electricity and one for gas, which can be served by different suppliers. Octopus said that on a household basis, it served 7.3mn customers, while British Gas says it serves nearly 7.5mn.

Octopus is one of a new band of challenger suppliers set up over the past decade to challenge the dominant Big Six suppliers including British Gas, EDF and E.On. 

After years at the top, the dominant groups were accused of taking customers for granted in a report by the UK’s competition watchdog in 2016. which paved the way for the introduction of an energy price cap in 2019. 

But many of the challengers were poorly run or had insufficient financial backing. Several of the newer operators collapsed in 2021 and 2022 as they were unable to withstand sudden surges in wholesale gas prices. 

Octopus emerged as a winner from the crisis, scooping up customers from collapsed rivals including 1.5mn from challenger competitor Bulb, via a government-run process that other rivals claimed was unfair. 

In 2023, Octopus bought Shell’s household energy supply business in the UK and Germany, as the FTSE 100 oil and gas giant retreated from its foray into the market.

It has also grown organically, saying in an announcement on Friday that almost 1mn customers had joined from other suppliers last year. 

Of the other challengers, Ovo Energy has also been a big success, buying SSE’s household retail supplier in 2019 and adding about 3.5mn customers in a stroke.

Cornwall Insight said that, following the market collapses, six energy companies now supplied more than 90 per cent of the market, albeit a different six than 10 years ago.

As well as Ovo’s purchase of SSE’s retail business, Npower’s UK household business was bought by E.on in 2019.

Morris, at Cornwall Insight, added: “Of course we must maintain an element of caution. Consumer choice remains a critical factor for both households and businesses when selecting their energy supplier.

“Some may argue that consumers aren’t benefiting from the same level of competition or deals seen in the years leading up to the crisis.”

Octopus also has a software platform, Kraken, which it uses and licenses to rivals, and manages a growing portfolio of wind farms and other assets. 

Greg Jackson, chief executive and founder, said the company had faced questions when it started about how it would take on the Big Six, but that the team had worked “incredibly hard” to build the business.

“In a world where the government is rightly trying to work out how you attract investment, [the answer is] avoid short-termism, invest in the long-run fundamentals.”

British Gas declined to comment.

FT : German foreign minister Annalena Baerbock attacks Olaf Scholz over Ukraine

German foreign minister Annalena Baerbock attacks Olaf Scholz over Ukraine aid
Support for Kyiv becomes key issue in February 23 election after chancellor blocks €3bn of extra funding

German foreign minister Annalena Baerbock has launched a thinly veiled attack on Chancellor Olaf Scholz for blocking additional military aid for Ukraine, accusing him of jeopardising European peace to “quickly win a few votes” as elections loom in the EU’s largest country.

Baerbock, whose Green party is pitching itself as the most robust supporter of Kyiv in campaigning for next month’s federal election, said it “really pains me” that Scholz was refusing to approve an extra €3bn in support to buy weapons.

Without naming Scholz, Baerbock said she was upset that, for some politicians, the question of “how I can quickly win a few votes in a general election is more important than the responsibility to really secure Europe’s peace and freedom”.

She told Politico: “Responsible politics does not mean going whichever way the wind blows, and perhaps changing direction during an election campaign.”

Support for Ukraine against Russian aggression has become a divisive campaign issue ahead of the vote in Germany on February 23, as European nations seek to step up their support for Kyiv amid fears that Donald Trump will scale back US aid after his inauguration as US president next week.

On Thursday, Keir Starmer made his first visit as UK prime minister to Ukraine to see President Volodymyr Zelenskyy. Starmer, who has drawn criticism for being slow to visit Kyiv compared with previous Conservative PMs, promised that Britain would play its “full part” in guaranteeing the country’s security.

Germany is the second-biggest donor of military aid to Ukraine after the US. Baerbock and defence minister Boris Pistorius, who is from Scholz’s Social Democrats (SDP), have been pushing for extra funds to buy more military equipment to help Ukraine defend itself against Russia, which invaded its neighbour nearly three years ago.

The additional money, which would come on top of €4bn already earmarked for 2025 in a provisional budget, would be used for purchases including three new Iris-T anti-aircraft batteries as well as air defence missiles and artillery shells.

But Scholz, who has sought to woo voters who harbour suspicions about the Nato military alliance and are fearful of Germany being dragged into a direct conflict with Russian President Vladimir Putin, has portrayed himself as the more cautious and prudent figure towards Moscow.

The chancellor has said he will approve the money only if it is funded by temporarily suspending the “debt brake” that places strict limits on government borrowing. “Otherwise the money is not there,” he said on Wednesday.

The chancellor, who has struggled to lift support for his party above 16 per cent, has warned voters that the fiscally hawkish Christian Democrats (CDU), who are leading the polls, will fund support for Ukraine by making deep spending cuts to social welfare.

The CDU has signalled that it will be willing to support a new Ukraine package but not if it means issuing more debt. 

Guntram Wolff, a fellow at Brussels think-tank Bruegel, said the funding of the package was “not so trivial”. The 2025 budget had not been passed due to the collapse of Scholz’s three-way coalition after he fired his Liberal finance minister, leaving a minority government with the SPD and Greens.

The impasse could be resolved with a parliamentary vote before the elections, but Wolff said the chancellor was reluctant to hold it because it would be too divisive for the SPD. 

“Scholz is deliberately ambiguous about his Ukraine support to speak to those in his party who are sceptical about sending more military weapons,” he said. “These people are very powerful and it makes sense politically to keep them on board.”

The chancellor, who is also seeking to avoid losing votes to the leftwing nationalist, pro-Russia Sahra Wagenknecht Alliance (BSW), has depicted election frontrunner Friedrich Merz, leader of the CDU, and Robert Habeck, the Greens’ candidate for chancellor, as dangerous “hotheads”.

He has refused to supply long-range Taurus missiles to Kyiv, citing fears of escalation with Russia.

Merz had cast himself as a more committed supporter of Kyiv and a more reliable partner for western allies than Scholz.

But he has recently toned down his language on the conflict and muffled loud calls to supply Taurus missiles as he faces increasing pressure from the pro-Russia Alternative for Germany (AfD). The far-right, anti-immigration party is second in the polls with about 20 per cent — roughly 10 points behind the CDU.

>>> Europe : Brokers Upgrades & Downgrades - 17th of January 2025 V2(+)

>>> Up
* Addnode Group AB Raised to Buy at Kepler Cheuvreux (+)
* Applied Materials Raised to Overweight at KeyBanc; PT $225
* Atrium Ljungberg Raised to Hold at Nordea
* Azelis Raised to Buy at UBS (+)
* Brenntag Raised to Equal-Weight at Barclays; PT 70 euros
* Duell Raised to Buy at Inderes; PT 9 euros
* Duell Raised to Buy at SEB Equities; PT 9 euros
* Epiroc Raised to Neutral at Oddo BHF; PT 195 kronor
* Great Portland Raised to Neutral at UBS (+)
* IMCD Raised to Overweight at Barclays; PT 187 euros
* M&C Saatchi Raised to Buy at Peel Hunt; PT 210 pence (+)
* Maire Raised to Buy at Kepler Cheuvreux (+)
* Orsted Raised to Buy at ABG; PT 400 kroner
* Salesforce Inc Raised to Buy at TD Cowen; PT $400
* SAP ADRs Raised to Buy at TD Cowen; PT $305
* Taylor Wimpey Raised to Add at Peel Hunt; PT 130 pence (+)
* TSMC ADRs PT Raised to $270 from $240 at Argus
* Virbac Raised to Buy at CIC; PT 400 euros (+)

>>> Down
* Brenntag Cut to Neutral at UBS (+)
* Dormakaba Cut to Neutral at Oddo BHF; PT 691 Swiss francs
* Evolution Cut to Sell at Redburn; PT 720 kronor
* HubSpot Cut to Hold at TD Cowen; PT $725
* Netcompany Cut to Hold at Jyske Bank; PT 375 kroner (+)
* Richemont Cut to Neutral at CIC; PT 160 Swiss francs (+)
* Sunrise Communications Re-Initiated Buy at Bank Vontobel (+)
* Tenaris Cut to Hold at Kepler Cheuvreux (+)
* Trustpilot Cut to Sell at Panmure Liberum; PT 245 pence (+)
* Wise Cut to Add at Peel Hunt; PT 1,100 pence
* Vivendi Cut to Hold at HSBC; PT 2.70 euros

>>> Initiation
* Baader Rated New Buy at DZ Bank; PT 4.80 euros
* Hexagon Purus Rated New Buy at Pareto Securities; PT 7 kroner
* Hexagon Composites Reinstated Buy at Pareto Securities
* HUTCHMED China Rated New Buy at UOB Kay Hian; PT 314.78 pence
* IG Design Cut to Hold at Panmure Liberum; PT 60 pence (+)
* Microsoft Rated New Overweight at Cantor; PT $509
* Oracle Reinstated Overweight at Cantor; PT $214
* Palantir Rated New Neutral at Cantor; PT $72
* Snowflake Rated New Overweight at Cantor; PT $201
* Sveafastigheter Rated New Buy at Arctic Securities; PT 51 kronor
* Vaisala Raised to Buy at Evli Bank; PT 56 euros

>>> Call
* European Pharma, Life Sciences Sector Cut to Neutral at Barclays (+)
* Trump Policy Risk Weighs on European Stocks, Barcays’ Cau Says (+)