Sanofi: FluGen’s Intranasal M2SR Flu Vaccine, co-administered with high dose vaccine, in older adults shows superiority over flu shot alone
- FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, announced the results of its study comparing the coadministration of intranasal M2SR and the high dose flu shot in an unprecedented study of older adults ages 65-85 years. The findings are reported today in the journal Lancet Infectious.
- The study evaluated the safety, tolerability, and immunological response to FluGen's investigational supra-seasonal, live, single-replication, intranasal influenza (flu) vaccine when administered with Sanofi's Fluzone High Dose inactivated influenza vaccine (IIV). There is a demonstrated unmet need for improved flu vaccine options, as current injectable vaccines primarily generate hemagglutinin (HA) antibodies and have shown only modest efficacy in most flu seasons. Funded by the U.S. Department of Defense (DOD), this study evaluated M2SR and Fluzone High Dose alone, and dosed concomitantly, in healthy adults 65-85 years of age, a population considered highly vulnerable to mortality from flu.