Regeneration Biomedical To Present Data on First Two Subjects in a Phase I Clinical Trial of Stem Cell Therapy delivered directly into the brains of Patients with Alzheimer’s Disease
- Wnt-activated, autologous, expanded, adipose-derived stem cells administered directly into lateral ventricles of the brain via Ommaya reservoir implanted under the scalp to bypass blood brain barrier
- Data to be presented at the Alzheimer’s Association International Conference (AAIC), 8 a.m. EDT, July 28, 2024
Announced a presentation on early data on the first two subjects from a Phase 1 clinical trial of Wnt-activated, autologous, expanded, adipose-derived stem cells (RB-ADSCs) administered directly into lateral ventricles of the brain in patients with Alzheimer’s Disease (AD). The data will be presented at the Alzheimer’s Association International Conference (AAIC) in Philadelphia at 8 a.m. EDT, July 28, 2024.
“There has been significant investment to find an effective treatment for AD,” said Christopher Duma, M.D., F.A.C.S., president, founder of RBI and presenter of the data. “However, recently approved anti-beta amyloid antibodies only slightly reduce the rate of cognitive decline at the risk of significant side effects. We are taking a very different approach using adipose-derived stem cells infused directly into the lateral ventricles to bypass the blood brain barrier (BBB). In vivo studies demonstrated that stem cells injected in this fashion do locate into the ventricles and parenchyma. In addition, an IRB-approved pilot study of an earlier version of our stem cell product in patients with advanced neurodegenerative diseases generated promising results. We are presenting early results from this single ascending dose, first-in-human Phase 1 trial. Though the first two patients were treated at the lowest dose based on the protocol, we have seen intriguing results on AD biomarkers, which we will share during our presentation.” - Source TradeTheNews.com